Recent biochemical studies indicate that calorie restriction (CR) is a widely accepted method for anti-aging intervention. CR and intermittent fasting (IF), which involves reduced calories but proper nutritional intake during specific periods, are interventions that can consistently promote health benefits, delay biological aging, and extend both average and maximal lifespan. Furthermore, CR can modulate age-related diseases such as Alzheimer’s disease, atherosclerosis, diabetes, obesity, cancer, and others. Advances in omics technologies have provided a technical breakthrough that enabled the investigation of DNA, RNA, proteins, and other cellular molecules and their comprehensive interactions in a biological context. Nowadays, it is possible to analyze and integrate biological processes that occur in aging systems at the molecular level using state-of-the-art techniques such as next-generation sequencing (NGS), proteomics, lipidomics, metabolomics, and epigenomics. Omics technology and systems gerontology provide predictive information on CR effects, molecular mechanisms, and pathways underlying the anti-aging actions of CR and IF. This Special Issue, “The effects of calorie restriction and intermittent fasting on health and disease”, focuses on the effects of calorie restriction and intermittent fasting on age-related inflammation, autophagy, metabolism, longevity, mitochondrial function, and age-related diseases.

"The Every-Other-Day Diet is the perfect diet for me." That's the satisfied declaration of a dieter who lost 41 pounds on the Every-Other-Day Diet. (And kept it off!) You too can expect dramatic results with this revolutionary approach to weight loss that is incredibly simple, easy, and effective. Created by Dr. Krista Varady, an associate professor of nutrition at the University of Illinois, the Every-Other-Day Diet will change the way you think of dieting forever. Among its many benefits: It's science-tested, science-proven. Dr. Varady has conducted many scientific studies on the Every-Other-Day Diet, involving hundreds of people, with consistently positive results published in top medical journals such as the American Journal of Clinical Nutrition and Obesity. Unlike most other diets, the Every-Other-Day Diet is proven to work. It's remarkably simple-and effective. On Diet Day, you limit calories. On Feast Day, you eat anything you want and as much as you want. You alternate Diet Day and Feast Day. And you lose weight, steadily and reliably. There's no constant deprivation. The Every-Other-Day Diet doesn't involve day after day of dietary deprivation--because you can still indulge every-other day. It's easy to keep the weight off. With other diets, you lose weight only to regain it, the frustrating fate of most dieters. But The Every-Other-Day Diet includes the Every-Other-Day Success Plan--an approach to weight maintenance proven to work in a study sponsored by the National Institutes of Health. This book offers all of the research, strategies, tips, and tools you need to believe in the Every-Other-Day Diet and easily implement it in your life. It also includes more than 80 quick and delicious recipes for Diet Day, as well as a list of tasty prepared foods that make meals as easy as 1-2-3. The Every-Other-Day Diet is perfect for anyone who wants to shed pounds and feel great, without hunger and defeat.

There is unequivocal experimental, epidemiological, and clinical evidence demonstrating a correlation between diet and increased risk of cardiovascular disease (CVD). While nutritionally-poor diets can have a significant negative impact on cardiovascular health, dietary interventions with specific nutrients and/or functional foods are considered cost-effective and efficient components of prevention strategies. It has been estimated that nutritional factors may be responsible for approximately 40% of all CVD. Indeed, in one of the seminal studies conducted on modifiable risk factors and heart health (the INTERHEART study), >90% of all myocardial infarctions were attributed to preventable environmental factors with nutrition identified as one of the important determinants of CVD. There is an increasing public interest in and scientific investigation into establishing dietary approaches that can be undertaken for the prevention and treatment of CVD. This Special Issue provides an insight into the influential role of nutrition and dietary habits on cardiovascular health and disease, as well as their mechanisms of therapeutic and preventive action.

Is it possible to eat what you like, most of the time, and get thinner and healthier as you do it? Simple answer: yes. You just have to restrict your calorie intake for two non-consecutive days each week (500 calories for women, 600 for men). This book brings together the results of recent revolutionary research to create a dietary programme that anyone can incorporate into their normal working life.

Reshape your body and mind by eating light during the day and filling up at night—the core tenet of this revolutionary nutrition program based on survival science. Join Ori Hofmekler as he turns to history for a solution to obesity and its attendant ailments—back to the primal habits of early cultures like nomads, hunter-gatherers, the Greeks, and the Romans. Drawing on both survival science and historical data, Hofmekler argues that robust health and a lean, strong body can best be achieved by mimicking the classical warrior mode of cycling—working and eating sparingly (undereating) during the day and filling up at night. A radical yet surprisingly simple lifestyle overhaul, the Warrior Diet Nutritional Program and the Controlling Fatigue Training Program can literally reshape your body! Inside, you’ll learn how to: • Find ideal fuel foods and food combinations to reduce body fat • Gain strength, speed, and resilience to fatigue through special drills • Prepare warrior meals and recipes • Increase sex drive, potency, and animal magnetism • Personalize the diet for your needs Featuring forewords by Fit for Life author Harvey Diamond and Fat That Kills author Dr. Udo Erasmus, The Warrior Diet shows readers weary of fad diets how to attain enduring vigor, explosive strength, a better appearance, and increased vitality and health.

Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series focuses on the nutritional issues associated with aging and the important metabolic consequences of diet, nutrition, and health. The book is subdivided into four parts that reflect the impact of nutrition from a biomolecular level to individual health. In Part One, chapters explore the general aspects of aging, aging phenotypes, and relevant aspects of nutrition related to the elderly and healthy aging. Part Two includes molecular and cellular targets of nutrition in aging, with chapters exploring lipid peroxidation, inflammaging, anabolic and catabolic signaling, epigenetics, DNA damage and repair, redox homeostasis, and insulin sensitivity, among others. Part Three looks at system-level and organ targets of nutrition in aging, including a variety of tissues, systems, and diseases, such as immune function, the cardiovascular system, the brain and dementia, muscle, bone, lung, and many others. Finally, Part Four focuses on the health effects of specific dietary compounds and dietary interventions in aging, including vitamin D, retinol, curcumin, folate, iron, potassium, calcium, magnesium, zinc, copper, selenium, iodine, vitamin B, fish oil, vitamin E, resveratrol, polyphenols, vegetables, and fruit, as well as the current nutritional recommendations. - Offers updated information and a perspectives on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of aging - Explores how nutritional factors are involved in the pathogenesis of aging across body systems - Investigates the molecular and genetic basis of aging and cellular senescence through the lens of the rapidly evolving field of molecular nutrition

Live healthier for longer with the international bestselling guide that will change your life 'The diet that holds the key to staying young . . . Dr Valter Longo is now considered one of the most influential voices in the 'fasting movement' The Times 'Dr Valter Longo is one of the real scientific pioneers when it comes to researching the impact of food on health' Dr Michael Mosley, bestselling author of The Fast Diet and The Clever Guts Diet ________ This is the clinically tested, revolutionary and straightforward diet to help you slow-down ageing, fight disease and lose weight. Following 30 years of research, Professor Valter Longo - a biochemist and one of the world's leading researchers into ageing - discovered that the secret of longevity lies in cellular regeneration triggered by a special diet. And that by adhering to his fasting-mimicking diet, we can heal ourselves through food. The Longevity Diet will guide you through the process with: - An easy-to-adopt lifetime plan - Fasting-mimicking diet 3-4 times a year, just 5 days at a time - 30 easy and delicious recipes based on Longo's 'Five Pillars of Longevity' In this lifelong, health-boosting plan, you will feel the benefits of fasting without the hunger and live a longer, healthier and more fulfilled life. And you'll get to try easy, plant-and-fish based recipes . . . - Great for the heart and rich in antioxidants: black rice with courgette and shrimp - For a good source of iron, snack on dark chocolate and yoghurt - For dessert try tangy dried cranberries and walnuts ________ Make simple changes that can extend your healthy lifespan * Prevent age-related muscle and bone loss * Build your resistance to diabetes, cardiovascular disease, Alzheimer's and cancer * Maintain your ideal weight and reduce abdominal fat