Provides clinicians with a basic background for treating craniofacial anomalies. Includes a CD-ROM with entire text and illustrations of the book in fully searchable PDF files Accompanying CD also contains three-dimensional movies that show reconstructions of embryos

This thoroughly revised 4th edition offers both clear descriptions and explanations of human embryonic development based on all the most up-to-date scientific discoveries and understanding. Particular attention is paid to the fundamental aspects of molecular mechanisms in development, introducing you to major families of important developmental molecules. Clinical aspects of development are covered throughout in boxed sections of text. First-rate illustrations complete this essential package. Integrates contemporary developmental knowledge with classical embryological understanding. Interprets complex molecular developments, to help you learn how exactly the embryo develops. Presents first-rate clinical photos and clear drawings, to help you to memorize and understand normal and abnormal development. Uses clear sections within the chapter and summaries at the end of each to help you navigate this complex subject. Includes review questions at the end of each chapter to help you assess your knowledge. Provides more coverage of molecular development to help you interpret complex information. Revises the section on the development of the head, particularly useful for dental students.

Providing an easy-to-digest, comprehensive review of what can be a complex and challenging subject, The Developing Human: Clinically Oriented Embryology, 12th Edition, covers all aspects of normal and abnormal embryonic and fetal development. In a clear, concise manner, this lavishly illustrated text has been extensively revised to incorporate recent research and current clinical practice guidelines, meeting the needs of medical and health sciences students as well as those in graduate programs. Online features include multiple-choice questions and narrated animations to further support student success. - Guides you month by month and stage by stage through embryo and fetal organ and systems development, using full-color photographs of clinical cases, relevant modern medical imaging, and numerous high-quality supportive figures. - Covers timely topics such as signaling pathways used during development, epigenetics, gene editing and CRISPR/Cas9 technology, reproductive in-vitro technology, stem-cell culture and creation and use of human organoids and early embryoids, morphogens, new teratogens (infections and environmental chemicals), and clinical genetics of common birth defects. - Emphasizes modern clinical imaging techniques, with many new 3D HD color rendered images of embryos and fetuses, 3D constructions of whole embryos, and imaging updates to sections on the head and neck, genitourinary system, ovarian development, nervous system, eyes, and integumentary system. - Details how molecular biology has affected clinical practice, including techniques such as recumbent DNA technology and stem cell manipulation. - Contains clinical "Blue Boxes" cases with answers to questions, numerous illustrations, crisp medical imaging figures, and many clinical photographs. - Provides clinically-oriented problems for each chapter, with corresponding answers and explanations designed to facilitate discussion and learning. In addition, multiple-choice questions and answers are available online for supportive self-assessment. - Features 18 outstanding, narrated, full-color animations to help you as you explore and learn the complexity of embryological development. - Provides the knowledge base needed for today's examinations, including USMLE Step 1, as well as for future clinical practice. - An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

In 1953, at the grand age of 92, Ferdinand Hochstetter submitted his famous collection of photographs of human embryos entitled: "Uber die Entwicklung der Formverhaltnisse des menschlichen Antlitzes." Together with others papers, this contribution was published in 1955, a year after Hochstetter's death. In unbroken combativeness, Hochstetter discussed his results with regard to those of earlier embryologists and to those of his own lifetime. Thus, in an obituary, Elze (1956) reported about one of Hochstetter's letters from the year of his death (1954): "nur einige blodsinnige Behauptungen, die Fischel in seiner Ent­ wicklung des Menschen verzapft hat, mochte ich vielleicht noch annageln," which may be translated as: "I would just like to pin down a few silly assertions that Fischel made in his Entwicklung des Menschen." In the first two paragraphs of his paper Hochstetter stated (in German, here translated freely): When I decided to write a detailed paper about the development of the morphology of the human face, too [in addition to a paper about morphology of the extremities in human embryos], I was especially moved by the fact that in none of the German manuals and textbooks on embryology known to me is there to be found a presentation of the development of the human face which could be considered - eveJ;l to a limited extent - rich in details, true, sufficiently illustrated, easy to understand by students as well as by scien­