From her apartment window, Doreen Durand witnesses a horrific accident. Officer Solloway wants to know what she saw. Doreen doesn't want to tell him - or anyone. But when she runs away it's straight into the fantastic world of the wealthy and mysterious Violet Cascade. With Officer Solloway in pursuit, and life becoming more bizarre by the day, Doreen is caught up in a surreal game of cat and mouse.

New York, 1916. Monroe Simonov, a song-plugger from Brooklyn, is in love with a Ziegfeld Follies dancer who has left him for California. Inez Kennedy, a fashion model in a department store, has just one season remaining to find a wealthy husband before she must return to the Midwest. Ana Denisova, a glamorous political exile, gives lectures and writes letters while she waits for the Russian people to overthrow their Tsar. Then America joins the war, jazz sweeps the city's dance floors, the old order is swept away by newly minted millionaires and the entire nation is gripped by the Red Scare. Although the world is changing faster than they could ever have imagined, Monroe, Inez and Ana discover that they are still subject to the tyranny of the heart. In this richly atmospheric and deftly plotted novel, the paths of these three central figures cross and re-cross, leaving a trail of passion, infidelity and betrayal, and hurtle towards an explosive climax.

"When you're looking for an adventure, be careful. You might get just what you wish for..." Bramlingham Abbey sits alone and isolated, crumbling from neglect, hidden from sight by an ever-expanding jungle of vegetation. Violet Cobb, a fearless girl from the coastal town of Grimsby, is left on the doorstep - moved from her home during Operation Pied Piper, designed to keep the children of England safe during the bombing raids of World War Two. She is a conspicuous 'townie' in a quiet village of farmers, far away from her friends and family. Left alone with no one but an extremely elderly caretaker, Violet is left to explore the Abbey by herself. She soon discovers two things; that Bramblingham Abbey is full of secrets, and a strange girl called Sarah that no one else seems to know. Sarah claims to be the granddaughter of Lady Audrey, the mysterious owner of the Abbey - but how can this be? While exploring the Abbey, Violet makes a horrifying discovery about Sarah in the secret chapel. Furious with what Violet has discovered Lady Audrey lays down an ultimatum; that Violet, now aware of the secret, must leave the Abbey and the village forever. But all is not lost. You cannot hold onto the past forever - you have to move forwards and live...

Anagram Solver is the essential guide to cracking all types of quiz and crossword featuring anagrams. Containing over 200,000 words and phrases, Anagram Solver includes plural noun forms, palindromes, idioms, first names and all parts of speech. Anagrams are grouped by the number of letters they contain with the letters set out in alphabetical order so that once the letters of an anagram are arranged alphabetically, finding the solution is as easy as locating the word in a dictionary.

Short listed for The An Post Irish Novel of the Year 2021.00His name was Joseph, but for years they had called him Panenka, a name that was his sadness and his story.0Panenka has spent 25 years living with the disastrous mistakes of his past, which have made him an exile in his home town and cost him his dearest relationships.0Now aged 50, Panenka begins to rebuild an improvised family life with his estranged daughter and her seven year old son. But at night, Panenka suffers crippling headaches that he calls his Iron Mask. Faced with losing everything, he meets Esther, a woman who has come to live in the town to escape her own disappointments. Together, they find resonance in each other's experiences and learn new ways to let love into their broken lives.

A do-it-yourself manual for culturing nerve cells, complete with recipes and protocols.

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.