With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which highlights the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis for the generation of molecular diversity. - Organized for rapid retrieval of published information on classes of synthetic transformations, linkers, and analytical methods - Serves as a laboratory manual for bench chemists - Includes a chapter on linkers to assist in choice of linking strategy - Discusses strengths and limitations of the various methods - Contains a structural index showing functional group transformations in solid-phase synthesis

In two volumes, this comprehensive handbook provides coverage of the whole area of combinatorial synthetic chemistry, including compound library design and synthesis.

Excellent text covers vector fields, plane homology and the Jordan Curve Theorem, surfaces, homology of complexes, more. Problems and exercises. Some knowledge of differential equations and multivariate calculus required.Bibliography. 1979 edition.

Combinatorial chemistry, by accelerating the process of chemical synthesis, is having a profound effect on all branches of chemistry, but especially on drug discovery. This informative text explains the origins of combinatorial chemistry and puts the many diverse library methods into context.It explains why some techniques are generally applicable and others are for specialists only. It also focuses on the renaissance of solid phase chemistry and describes the range of available reactions. This is the first single author book in this important, growing field and it describes thebeneficial impact of combinatorial chemistry, especially for the discovery and optimisation of biologically active molecules. This concise and comprehensive overview of combinatorial techniques is an essential text for final year undergraduates, postgraduates, academics and industrialists inchemistry, bio-orgainc chemistry, medicinal chemistry and drug discovery. It provides an accessible introduction to the area for those new to these methods and a valuable reference text to those experienced in this field.

Written by one of the foremost experts in the field, Algebraic Combinatorics is a unique undergraduate textbook that will prepare the next generation of pure and applied mathematicians. The combination of the author’s extensive knowledge of combinatorics and classical and practical tools from algebra will inspire motivated students to delve deeply into the fascinating interplay between algebra and combinatorics. Readers will be able to apply their newfound knowledge to mathematical, engineering, and business models. The text is primarily intended for use in a one-semester advanced undergraduate course in algebraic combinatorics, enumerative combinatorics, or graph theory. Prerequisites include a basic knowledge of linear algebra over a field, existence of finite fields, and group theory. The topics in each chapter build on one another and include extensive problem sets as well as hints to selected exercises. Key topics include walks on graphs, cubes and the Radon transform, the Matrix–Tree Theorem, and the Sperner property. There are also three appendices on purely enumerative aspects of combinatorics related to the chapter material: the RSK algorithm, plane partitions, and the enumeration of labeled trees. Richard Stanley is currently professor of Applied Mathematics at the Massachusetts Institute of Technology. Stanley has received several awards including the George Polya Prize in applied combinatorics, the Guggenheim Fellowship, and the Leroy P. Steele Prize for mathematical exposition. Also by the author: Combinatorics and Commutative Algebra, Second Edition, © Birkhauser.

The continued successes of large- and small-scale genome sequencing projects are increasing the number of genomic targets available for drug d- covery at an exponential rate. In addition, a better understanding of molecular mechanisms—such as apoptosis, signal transduction, telomere control of ch- mosomes, cytoskeletal development, modulation of stress-related proteins, and cell surface display of antigens by the major histocompatibility complex m- ecules—has improved the probability of identifying the most promising genomic targets to counteract disease. As a result, developing and optimizing lead candidates for these targets and rapidly moving them into clinical trials is now a critical juncture in pharmaceutical research. Recent advances in com- natorial library synthesis, purification, and analysis techniques are not only increasing the numbers of compounds that can be tested against each specific genomic target, but are also speeding and improving the overall processes of lead discovery and optimization. There are two main approaches to combinatorial library production: p- allel chemical synthesis and split-and-mix chemical synthesis. These approaches can utilize solid- or solution-based synthetic methods, alone or in combination, although the majority of combinatorial library synthesis is still done on solid support. In a parallel synthesis, all the products are assembled separately in their own reaction vessels or microtiter plates. The array of rows and columns enables researchers to organize the building blocks to be c- bined, and provides an easy way to identify compounds in a particular well.

An elementary text that can be understood by anyone with a background in high school geometry, Invitation to Combinatorial Topology offers a stimulating initiation to important topological ideas. This translation from the original French does full justice to the text's coherent presentation as well as to its rich historical content. Subjects include the problems inherent to coloring maps, homeomorphism, applications of Descartes' theorem, and topological polygons. Considerations of the topological classification of closed surfaces cover elementary operations, use of normal forms of polyhedra, reduction to normal form, and application to the geometric theory of functions. 1967 edition. 108 figures. Bibliography. Index.