The Collagens: Biochemistry and Pathophysiology
Title | The Collagens: Biochemistry and Pathophysiology PDF eBook |
Author | Eugene J. Kucharz |
Publisher | Springer Science & Business Media |
Pages | 429 |
Release | 2012-12-06 |
Genre | Science |
ISBN | 3642761976 |
This book describes every manner in which collagen is involved in normal anddisease-altered states of the various organs and systems. In the first part of the book the biochemical aspects of collagens are reviewed, including their structure, heterogeneity, syntheses, and degradation. The main part focuses on the involvement of collagen in bone, cartilage, tendon, muscle, heart, vessels, lungs, liver, skin, eye, ear, teeth, periodontal tissues, kidneys and reproductive, hemopoietic,and nervous systems. The influence of radiation and nutrition on collagen, the role of collagen in neoplasms, the hormonal control of its metabolism, immunobiology and the pharmacology of collagen are also described. The most important feature of the book is the comprehensive review of the medical aspects of collagen, from those known in detail to those only hypothesized including hereditary disorders affecting collagen and so-called collagen diseases. Each chapter reviewsknown or possible mechanisms of collagen involvement and changes in indices of collagen which can be measured in clinical practice to monitor these phenomena. The fact that collagen is involved into the pathophysiology of almost all organs and body systems means that physicians in almost all branches of medicine will find this book of great interest.
Connective Tissues
Title | Connective Tissues PDF eBook |
Author | R. Fricke |
Publisher | Springer Science & Business Media |
Pages | 469 |
Release | 2012-12-06 |
Genre | Medical |
ISBN | 3642619320 |
connective tissues are essential for the physical functioning of the animals's body. The condition of the various connective tissues is governed by biochemical factors, anabolism and catabolism, that are controlled by specific enzymes. Any change outside the normal range of metabolism, for instance induced by immunological reactions, may induce a pathological disturbance. The result can be acute or chronic inflammation, or loss of normal function, expressed in loosening, dilatation, breaking, wear, stiffness, shrinking, scars, stenosis, and cirrhosis or any other kind of fibrosis. A first step toward improving our understanding of the feedback mecha nism that maintains the biological status and texture of a given connective tissue is to combine what is known about synthesis and enzymatic degradation of the components of fibers and ground substance. Common pathological phenomena like chronic inflammation of immune reactions can be either the result of the cause of disturbances in the sensitive balance of connective tissue metabolism. Nowadays con nective tissues are less and less regarded as brady trophic tissue but rather as a stimulating and many-sided problem of research. Before we can understand the pathogenesis of the connective tissue diseases that result in the destructive processes mentioned above, basic research will be necessary. This research will be furthered by a constant exchange of information and the results of· observations. To promote this exchange of information between scientists, symposia on connective tissue research are organized at regular intervals.
Biochemistry of Collagen
Title | Biochemistry of Collagen PDF eBook |
Author | Gopalasamudram Ramachandran |
Publisher | Springer Science & Business Media |
Pages | 546 |
Release | 2013-06-29 |
Genre | Science |
ISBN | 1475746024 |
Collagen is a fascinating protein not only because of its ubiquitous occurrence in multicellular animals, but also because of its unique chemi cal structure. As the predominant constituent in bone, cartilage, skin, tendon, and tooth, it is not surprising that collagen is of interest to anatomists, biochemists, biomedical engineers, cell biologists, dermatolo gists, dental surgeons, leather chemists, orthopedic surgeons, physiologists, physicians, zoologists, and a host of others. This book was planned to provide an up-to-date comprehensive survey of all aspects of biochemistry of collagen. The recent discovery of genetically distinct collagens with tissue specificity has opened a new era in collagen biochemistry, and Karl Piez discusses this in the opening chapter on primary structure. In the next chapter, Ramachandran and Rama krishnan deal with the molecular structure of collagen, placing special emphasis on the conformational aspects of its polypeptide chains. Follow ing the consideration of primary and secondary structure of collagen, the three-dimensional arrangement of collagen molecules in the fibrils is covered by Miller in Chapter 3. Collagen is generally in the insoluble state in the living organism due to the cross-linking of individual molecules, and Tanzer describes the various aspects of this cross-linkage in Chapter 4. The biosynthesis of collagen is discussed in depth by Prockop and his colleagues.
Biochemistry of Collagens, Laminins and Elastin
Title | Biochemistry of Collagens, Laminins and Elastin PDF eBook |
Author | Morten Karsdal |
Publisher | Academic Press |
Pages | 274 |
Release | 2016-07-29 |
Genre | Science |
ISBN | 0128098996 |
Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides a comprehensive introduction to collagen and structural proteins Provides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation Includes a chapter dedicated to the biomarkers of structural proteins Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states
Structure, Molecular Biology, and Pathology of Collagen
Title | Structure, Molecular Biology, and Pathology of Collagen PDF eBook |
Author | Raul Fleischmajer |
Publisher | |
Pages | 618 |
Release | 1990 |
Genre | Medical |
ISBN |
Connective Tissue Disease
Title | Connective Tissue Disease PDF eBook |
Author | Jouni Uitto |
Publisher | CRC Press |
Pages | 576 |
Release | 2021-07-29 |
Genre | Science |
ISBN | 1000447227 |
This book is a collection of works that canvass many of the recent developments in various areas of connective tissue research. It focuses on the structure of the components, molecular organization and pathology of the extracellular matrix.
Collagen
Title | Collagen PDF eBook |
Author | Marcel E. Nimni |
Publisher | CRC Press |
Pages | 516 |
Release | 2018-01-18 |
Genre | Medical |
ISBN | 135108769X |
This series was conceived with the idea of integrating current aspects of ongoing research in the collagen field. The book consists of a spectrum of papers which discus divers aspects such as X-ray structure, the thermodynamics and mechanism of fibrillogenesis, and the use of collagen as a biomaterial for the manufacturing of many implantable, sometimes lifesaving, devises.