Prestigious contributors summarize current knowledge regarding the biosynthesis of tetrapyrrole pigments--chlorophyll, haem, vitamin B12. Describes the structure and regulation of key enzymes along with various pathways, molecular genetic studies and structural characterization of the natural biosynthetic intermediates.

Excluding the biological polymers proteins, lipids and nucleic acids, modified tetrapyrroles are the biological molecules that have had the greatest impact on the evolution of life over the past 4 billion years. They are involved in a wide variety of fundamental processes that underpin central primary metabolism in all kingdoms of life, from photosynthesis to methanogenesis. Moreover, they bring colour into the world and it is for this reason that these compounds have been appropriately dubbed the ‘pigments of life’. To understand how and why these molecules have been so universally integrated into the life processes one has to appreciate the chemical properties of the tetrapyrrole scaffold and, where appropriate, the chemical characteristics of the centrally chelated metal ion. This book addresses why these molecules are employed in Nature, how they are made and what happens to them after they have finished their usefulness.

The study of the structure and function of tetrapyrrolic compounds has excited the interests of organic chemists, biochemists, botanists and biologists for more than a hundred years. Scientific analysis began with the first descriptions of naturally occurring porphyrins, and progress was made towards understanding the structure of chlorophyll. This was followed by the use of newly available isotopes of carbon and nitrogen to investigate the formation of porphyrins in biological systems. Further discoveries led to the elucidation of the atoms in protoporphyrin IX, made possible by the application of physical methods, such as NMR spectroscopy and recombinant DNA technology. The present volume discusses many more exciting and unexpected developments which have been made in the field over the last ten to fifteen years. While not all questions have yet been answered, the forum is set for a great scope of further research in the study of tetrapyrroles.• Of interest to biochemists, organic chemists and plant scientists• The book focusses on the exciting and unexpected developments in the field of tetrapyrolles over the last ten years• It paves the way for future research in this area

Algae, including cyanobacteria, are in the spotlight today for a number of reasons; firstly it has become abundantly clear over recent years that algae have been neglected in terms of basic research and that knowledge gap is being rapidly closed with the establishment of some surprising discoveries, such as the presence of Near-Infra-Red-Absorbing cyanobacteria and a wealth of natural products; secondly molecular approaches have provided a wealth of approaches to genetically modify algae and produce value-added products; thirdly it has become clear just how important, marine phytoplankton is to global carbon capture and the production of food globally; and fourthly, it has also become clear that algae present unparalleled opportunities to generate biofuels in a sustainable and non-polluting way. This volume presents 15 chapters by world experts on their subjects, ranging from reviews of algal diversity and genetics to in-depth reviews of special algal groups such as diatoms (which account for over 30% of marine carbon capture). Other chapters chart the ways in which this carbon capture occurs or how there are a multiplicity of ways in which algae intercept sun light and deploy this energy for carbon capture. A fascinating aspect here is the way in which sun light is harvested. A special chapter is devoted to the very recent and exciting possibility that algae use coherent light energy transformation to enhance the efficiency of light capture, an aspect of quantum physics that has implications for future developments at several levels and a variety of industries. Just how and why algae use Chlorophyll a as the major light capture pigment is discussed in several chapters. However, attention is also given to those cyanobacteria, which have been found to use the special Near-Infra Red absorbing chlorophylls mentioned above. And attention is also given to those algae that employ phycobiliproteins to fill in the “green window”, i.e., the spectral region from 400 – 650 nm, which is not efficiently covered by chlorophyll and carotenoid pigments. Photoinhibition and photoprotection is the subject area of several chapters and one which it is essential to understand a we work towards greater efficiency of algal photosynthesis. A final chapter is devoted to understanding the molecular basis for coral bleaching, a much-neglected area that is essential in trying to come up with solutions to this very worrying phenomenon, caused by global warming and ocean acidification. This is a book for research scientists, environmentalists, planners in a range of areas including those of marine resources, nutrient control and pollution of water bodies and that growing body of concerned citizens interested in controlling carbon emissions and global warming. Special attention has been given to generating a set of articles that will be read by university students, informed laymen and all those whose wish to understand the rapid changes that have come about in our knowledge of algae over the past decade.

The importance of metals in biology, the environment and medicine has become increasingly evident over the last twenty five years. The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic chemistry and biology constitutes the subject called Biological Inorganic Chemistry. The present text, written by a biochemist, with a long career experience in the field (particularly iron and copper) presents an introduction to this exciting and dynamic field. The book begins with introductory chapters, which together constitute an overview of the concepts, both chemical and biological, which are required to equip the reader for the detailed analysis which follows. Pathways of metal assimilation, storage and transport, as well as metal homeostasis are dealt with next. Thereafter, individual chapters discuss the roles of sodium and potassium, magnesium, calcium, zinc, iron, copper, nickel and cobalt, manganese, and finally molybdenum, vanadium, tungsten and chromium. The final three chapters provide a tantalising view of the roles of metals in brain function, biomineralization and a brief illustration of their importance in both medicine and the environment.Relaxed and agreeable writing style. The reader will not only fiind the book easy to read, the fascinating anecdotes and footnotes will give him pegs to hang important ideas on.Written by a biochemist. Will enable the reader to more readily grasp the biological and clinical relevance of the subject.Many colour illustrations. Enables easier visualization of molecular mechanismsWritten by a single author. Ensures homgeneity of style and effective cross referencing between chapters

The first dedicated new work since 1991, this book reviews recent progress and current studies in the chemistry, metabolism and spectroscopy of chlorophylls, bacteriochlorophylls and their protein complexes. Also discussed is progress on the applications of chlorophylls as photosensitizers in photodynamic therapy of cancerous tumours, and as molecular probes in biochemistry, medicine, plant physiology, ecology and geochemistry. Each section offers an introductory overview followed by concise, focused and fully-referenced chapters written by experts.