Jonathan goes on a secret quest to Rome, and Flavia, Nubia and Lupus set out to find him. Their dangerous mission takes them to the Golden House of Nero where a deadly assassin is rumoured to be at work - and they learn what happened to Jonathan's family during the terrible destruction of Jerusalem nine years earlier.

Flavia and Nubia follow Jonathan to Rome and into the Golden House built by the emperor Nero, where a dangerous assassin lurks.

Many men killed Julius Caesar. Only one man was determined to kill the killers. From the spring of 44 BC through one of the most dramatic and influential periods in history, Caesar's adopted son, Octavian, the future Emperor Augustus, exacted vengeance on the assassins of the Ides of March, not only on Brutus and Cassius, immortalized by Shakespeare, but all the others too, each with his own individual story. The last assassin left alive was one of the lesser-known: Cassius Parmensis was a poet and sailor who chose every side in the dying Republic's civil wars except the winning one, a playwright whose work was said to have been stolen and published by the man sent to kill him. Parmensis was in the back row of the plotters, many of them Caesar's friends, who killed for reasons of the highest political principles and lowest personal piques. For fourteen years he was the most successful at evading his hunters but has been barely a historical foot note--until now. The Last Assassin dazzlingly charts an epic turn of history through the eyes of an unheralded man. It is a history of a hunt that an emperor wanted to hide, of torture and terror, politics and poetry, of ideas and their consequences, a gripping story of fear, revenge, and survival.

When a Roman widow shows unusual interest in Flavia's father, Flavia decides to discover Cartila's true motives by performing twelve tasks, just like the Greek hero Hercules.

Suspecting their friend Jonathan is alive, Flavia, Nubia, and Lupus go to Rome for the Colosseum Games, facing wild beasts, criminals, conspirators, and gladiators, and where Nubia is called upon to make a terrible choice.

A ragged stranger and the prospect of losing her family's fortune lead Flavia Gemina and her friends, Jonathan, Lupus, and Nubia to a seaside villa where possible danger and treasure are close at hand.

Parenti presents a story of popular resistance against entrenched power and wealth. As he carefully weighs the evidence in the murder of Caesar, he sketches in the background to the crime with fascinating detail about Roman society.