THE APPLICATION OF HEAT IN ONCOLOGY Understand the use of heat to destroy tumors with this comprehensive guide Heat is an indispensable resource in the destruction of cancerous tumors to potentially treat cancers. There are also real challenges, however, involved in the total destruction of tumors without destroying healthy tissue surrounding the tumor in the process. A detailed understanding of the propagation of thermal energy, induced heating, and tissue responses to heat is required to safely and successfully apply heat-based technologies in clinical oncology. The Application of Heat in Oncology supplies this understanding, with a thorough, comprehensive overview of the principle and practice involved. Offering both a detailed introduction to the physics and thermodynamics of induced heat and an analysis of its clinical applications, this is an essential resource for clinicians, technicians, and others in oncological practice. The Application of Heat in Oncology readers will also find: Guidelines for applying heat both safely and effectively Detailed discussion of topics including energy delivery (e.g., via RF, MW, ultrasound, laser, cryoagents, hyperthermia, nanoparticles, etc.), temperature assessment, damage assessment, image guidance, and more Summary of current practice along with suggestions for future areas of technological improvement The Application of Heat in Oncology is ideal for all clinicians working in the field of cancer treatment, including medical students, residents, researchers, engineers, radiologists, surgeons, and more.

Hyperthermia in oncology is the application of heat to a patient s body for the purpose of cancer treatment. In recent years, its use has seen rapid development, with a large amount of clinical data becoming available. Hyperthermia in Oncology synthesizes the current research on the topic and provides treatment protocols for using localized as well as whole-body hyperthermia. The differentiating characteristic of this book is the systematic documentation of evidence. Standard procedures for cancer diagnosis, treatment, and management are included along with guidance for evaluating clinical therapeutic effects. The book examines the unique effects of hyperthermia treatment with a large quantity of evidence-based data from both medical research and clinical practice. It reviews outcomes of cancer patients clinically treated at Clifford Hospital, a state-of-the-art facility with Joint Commission International accreditation located in Guangzhou, China. A diverse set of clinical cases is discussed. For each case, a scientific, rational, and practical patient treatment plan is presented. The amount and type of heat administered to patients are analyzed when hyperthermia is used in conjunction with surgery, chemotherapy, radiotherapy, or other therapeutic strategies. Although hyperthermia is not an independent treatment method for cancer, it can play a significant synergistic and complementary role. As such, this book can serve as a valuable clinical guide for the effective use of hyperthermia in integrative cancer therapy."

Heat Transfer and Fluid Flow in Biological Processes covers emerging areas in fluid flow and heat transfer relevant to biosystems and medical technology. This book uses an interdisciplinary approach to provide a comprehensive prospective on biofluid mechanics and heat transfer advances and includes reviews of the most recent methods in modeling of flows in biological media, such as CFD. Written by internationally recognized researchers in the field, each chapter provides a strong introductory section that is useful to both readers currently in the field and readers interested in learning more about these areas. Heat Transfer and Fluid Flow in Biological Processes is an indispensable reference for professors, graduate students, professionals, and clinical researchers in the fields of biology, biomedical engineering, chemistry and medicine working on applications of fluid flow, heat transfer, and transport phenomena in biomedical technology. - Provides a wide range of biological and clinical applications of fluid flow and heat transfer in biomedical technology - Covers topics such as electrokinetic transport, electroporation of cells and tissue dialysis, inert solute transport (insulin), thermal ablation of cancerous tissue, respiratory therapies, and associated medical technologies - Reviews the most recent advances in modeling techniques

Oncothermia is the next generation medical innovation that delivers selective, controlled and deep energy for cancer treatment. The basic principles for oncothermia stem from oncological hyperthermia, the oldest approach to treating cancer. Nevertheless, hyperthermia has been wrought with significant controversy, mostly stemming from shortcomings of controlled energy delivery. Oncothermia has been able to overcome these insufficiencies and prove to be a controlled, safe and efficacious treatment option. This book is the first attempt to elucidate the theory and practice of oncothermia, based on rigorous mathematical and biophysical analysis, not centered on the temperature increase. It is supported by numerous in-vitro and in-vivo findings and twenty years of clinical experience. This book will help scientists, researchers and medical practitioners in understanding the scientific and conceptual underpinnings of oncothermia and will add another valuable tool in the fight against cancer. Professor Andras Szasz is the inventor of oncothermia and the Head of St Istvan University's Biotechnics Department in Hungary. He has published over 300 papers and lectured at various universities around the world. Dr. Oliver Szasz is the managing director of Oncotherm, the global manufacturer and distributor of medical devices for cancer treatment used in Europe & Asia since the late 1980s. Dr. Nora Szasz is currently a management consultant in healthcare for McKinsey & Co.

An authoritative guide to theory and applications of heat transfer in humans Theory and Applications of Heat Transfer in Humans 2V Set offers a reference to the field of heating and cooling of tissue, and associated damage. The author—a noted expert in the field—presents, in this book, the fundamental physics and physiology related to the field, along with some of the recent applications, all in one place, in such a way as to enable and enrich both beginner and advanced readers. The book provides a basic framework that can be used to obtain ‘decent’ estimates of tissue temperatures for various applications involving tissue heating and/or cooling, and also presents ways to further develop more complex methods, if needed, to obtain more accurate results. The book is arranged in three sections: The first section, named ‘Physics’, presents fundamental mathematical frameworks that can be used as is or combined together forming more complex tools to determine tissue temperatures; the second section, named ‘Physiology’, presents ideas and data that provide the basis for the physiological assumptions needed to develop successful mathematical tools; and finally, the third section, named ‘Applications’, presents examples of how the marriage of the first two sections are used to solve problems of today and tomorrow. This important text is the vital resource that: Offers a reference book in the field of heating and cooling of tissue, and associated damage. Provides a comprehensive theoretical and experimental basis with biomedical applications Shows how to develop and implement both, simple and complex mathematical models to predict tissue temperatures Includes simple examples and results so readers can use those results directly or adapt them for their applications Designed for students, engineers, and other professionals, a comprehensive text to the field of heating and cooling of tissue that includes proven theories with applications. The author reveals how to develop simple and complex mathematical models, to predict tissue heating and/or cooling, and associated damage.

Following an introductory overview, Hyperthermia In Cancer Treatment: A Primer comprehensively describes the biological reasons for associating hyperthermia with radiation and chemotherapy and the biological and clinical effects of hyperthermia on cancerous and normal tissues. The volume’s 20 chapters are arranged in three principal parts: physical and methodological studies, biologic principles, and clinical studies.

Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.