The Aging Skeleton is a comprehensive and timely book on all aspects of the skeleton as it ages, including basic mechanisms and pathways as well as pathobiology. Chapters cover general aspects and models of aging, determinants and maintenance of peak bone mass, mechanisms of age-related bone loss, quantifiable manifestations of age-related bone loss, fractures, and therapeutics. - Covers all aspects of the aging skeleton in one comprehensive volume - Looks at the influence of genetics, nutrition, environment, hormones, and other factors on bone mass - Provides a thorough discussion of fractures, one of the major consequences of the aging skeleton - Reviews current therapeutic approaches and methods - Written by internationally renowned authors and edited by leaders in the field - Is the only book available on this subject

Age Estimation of the Human Skeleton is a needed up-to-date book providing anthropologists and anatomists with a broad spectrum of techniques focused on aging human skeletal remains. It represents the most current reference book devoted entirely to estimating age at death for skeletonized and decomposed human remains and is a convenient starting point for practical and research applications. This book is a valuable reference for all individuals interested in the identification or analysis of human remains including forensic anthropologists, bioarchaeologists, forensic odontologists, pathologists and anatomists at student and professional levels. Age Estimation of the Human Skeleton would serve as an ideal supplemental textbook for introductory and advanced osteology and forensic anthropology courses. Age Estimation of the Human Skeleton is a collection of some of the latest research in age estimation techniques of human skeletal remains. It compiles recent scientific research on age at death estimation using dental and gross skeletal morphological indicators of age, as well as histological and multifactorial age estimation techniques. Age estimation methods from all life-stage categories, including: fetal, sub-adult, and adult are included in the book. Age Estimation of the Human Skeleton also includes chapters that evaluate and review the older, more traditional aging techniques as well as information that explores future directions and considerations for research in this area. Overall, Age Estimation of the Human Skeleton bolsters the references available to researchers in academic, laboratory, and medicolegal facilities and is an attractive text to a sizable spectrum of analysts.

This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are related to the subject. Key focus points for this volume are nutrition, external factors and genetics on aging. There will also be chapters that will focus on various organs or tissues in which aging has been well studied, like the eyes, the muscles, the immune system and the bones. The aim of the book project and the book project that is published in concert with this volume is to bring the subcellular and clinical areas into closer contact.

This book, part contributed volume, part proceedings, discusses state-of-the-art advances on human cell transformation in cell models for the study of cancer and aging. Several of the chapters are from the Human Cell Transformation: Advances in Cell Models for the Study of Cancer and Aging conference that was held in June 2018 at McGill University. The authors represent international expertise on a wide variety of topics ranging from different types of cancer (prostate, bone, breast, etc.) to tumor microenvironment, tumor progression, homogeneity, and possible therapies and treatments.

This first-ever Surgeon General's Report on bone health and osteoporosis illustrates the large burden that bone disease places on our Nation and its citizens. Like other chronic diseases that disproportionately affect the elderly, the prevalence of bone disease and fractures is projected to increase markedly as the population ages. If these predictions come true, bone disease and fractures will have a tremendous negative impact on the future well-being of Americans. But as this report makes clear, they need not come true: by working together we can change the picture of aging in America. Osteoporosis, fractures, and other chronic diseases no longer should be thought of as an inevitable part of growing old. By focusing on prevention and lifestyle changes, including physical activity and nutrition, as well as early diagnosis and appropriate treatment, Americans can avoid much of the damaging impact of bone disease and other chronic diseases. This Surgeon General's Report brings together for the first time the scientific evidence related to the prevention, assessment, diagnosis, and treatment of bone disease. More importantly, it provides a framework for moving forward. The report will be another effective tool in educating Americans about how they can promote bone health throughout their lives. This first-ever Surgeon General's Report on bone health and osteoporosis provides much needed information on bone health, an often overlooked aspect of physical health. This report follows in the tradition of previous Surgeon Generals' reports by identifying the relevant scientific data, rigorously evaluating and summarizing the evidence, and determining conclusions.

Paleodemography is the field of enquiry that attempts to identify demographic parameters from past populations (usually skeletal samples) derived from archaeological contexts, and then to make interpretations regarding the health and well-being of those populations. However, paleodemographic theory relies on several assumptions that cannot easily be validated by the researcher, and if incorrect, can lead to large errors or biases. In this book, physical anthropologists, mathematical demographers and statisticians tackle these methodological issues for reconstructing demographic structure for skeletal samples. Topics discussed include how skeletal morphology is linked to chronological age, assessment of age from the skeleton, demographic models of mortality and their interpretation, and biostatistical approaches to age structure estimation from archaeological samples. This work will be of immense importance to anyone interested in paleodemography, including biological and physical anthropologists, demographers, geographers, evolutionary biologists and statisticians.

This volume in the ICAZ series deals with the technical advances made over the last twenty years in the field of ageing and sexing animal bones. The analysis of ancient DNA holds great possibilities for sexing certain faunal assemblages (though by no means all), which is an urgent issue in the study of hunting and animal husbandry. It can be assumed that our forebears used more subtle taxonomic criteria than we do today, and it is important therefore that we are able to recognise traits that will allow for more accurate classification in terms of calendar age or sex. The eighteen papers in this book examine the state of research for various techniques of age/sex determination and assess potential future development.