Fungi research and knowledge grew rapidly following recent advances in genetics and genomics. This book synthesizes new knowledge with existing information to stimulate new scientific questions and propel fungal scientists on to the next stages of research. This book is a comprehensive guide on fungi, environmental sensing, genetics, genomics, interactions with microbes, plants, insects, and humans, technological applications, and natural product development.

Entheogens and the Development of Culture makes the radical proposition that mind-altering substances have played a major part not only in cultural development but also in human brain development. Researchers suggest that we have purposely enhanced receptor sites in the brain, especially those for dopamine and serotonin, through the use of plants and fungi over a long period of time. The trade-off for lowered functioning and potential drug abuse has been more creative thinking--or a leap in consciousness. Experiments in entheogen use led to the development of primitive medicine, in which certain mind-altering plants and fungi were imbibed to still fatigue, pain, or depression, while others were taken to promote hunger and libido. Our ancestors selected for our neural hardware, and our propensity for seeking altered forms of consciousness as a survival strategy may be intimately bound to our decision-making processes going back to the dawn of time. Fourteen essays by a wide range of contributors—including founding president of the American Anthropological Association’s Anthropology of Religion section Michael Winkelman, PhD; Carl A. P. Ruck, PhD, Boston University professor of classics and an authority on the ecstatic rituals of the god Dionysus; and world-renowned botanist Dr. Gaston Guzma, member of the Colombian National Academy of Sciences and expert on hallucinogenic mushrooms—demonstrate that altering consciousness continues to be an important part of human experience today. Anthropologists, cultural historians, and anyone interested in the effects of mind-altering substances on the human mind and soul will find this book deeply informative and inspiring.

Mycology, the study of fungi, originated as a subdiscipline of botany and was a des criptive discipline, largely neglected as an experimental science until the early years of this century. A seminal paper by Blakeslee in 1904 provided evidence for self incompatibility, termed "heterothallism", and stimulated interest in studies related to the control of sexual reproduction in fungi by mating-type specificities. Soon to follow was the demonstration that sexually reproducing fungi exhibit Mendelian inheritance and that it was possible to conduct formal genetic analysis with fungi. The names Burgetf, Kniep and Lindegren are all associated with this early period of fungal genet ics research. These studies and the discovery of penicillin by Fleming, who shared a Nobel Prize in 1945, provided further impetus for experimental research with fungi. Thus began a period of interest in mutation induction and analysis of mutants for biochemical traits. Such fundamental research, conducted largely with Neurospora crassa, led to the one gene: one enzyme hypothesis and to a second Nobel Prize for fungal research awarded to Beadle and Tatum in 1958. Fundamental research in biochemical genetics was extended to other fungi, especially to Saccharomyces cerevisiae, and by the mid-1960s fungal systems were much favored for studies in eukaryotic molecular biology and were soon able to compete with bacterial systems in the molecular arena.