This book presents the biochemistry of mammalian cells, relates events at the cellular level to the subsequent physiological processes in the whole animal, and cites examples of human diseases derived from aberrant biochemical processes.

This book presents a clear and precise discussion of the biochemistry of eukaryotic cells, particularly those of mammalian tissues, relates biochemical events at a cellular level to the subsequent physiological processes in the whole animal, and cites examples of abnormal biochemical processes in human disease. The organization and content are tied together to provide students with the complete picture of biochemistry and how it relates to human diseases.

This completely revised and updated edition provides a comprehensive overview of mammalian biochemistry. Topics examined include introductions to the structure of the cell and protein composition, followed by in depth coverage of biological membranes, bioenergetics, metabolism of carbohydrates, lipids, amino acids and nucleotides. Chapters have been updated on DNA replication and repair, recombinant DNA and biotechnology, regulation of gene expression and RNA structure and function. Further subjects covered include protein synthesis and post-translational modification, biochemistry of hormones, and biotransformation.

Biochemistry provides a platform for convergence of all scientific knowledge about the operation of life and, therefore, it finds an important place in the curriculum of all the medical sciences. The present book is an attempt in this direction in the form of a student-friendly, yet comprehensive and up-to-date text.

This textbook provides a strong foundation and a clear overview for students of membrane biology and an invaluable synthesis of cutting-edge research for working scientists. The text retains its clear and engaging style, providing a solid background in membrane biochemistry, while also incorporating the approaches of biophysics, genetics and cell biology to investigations of membrane structure, function and biogenesis to provide a unique overview of this fast-moving field. A wealth of new high resolution structures of membrane proteins are presented, including the Na/K pump and a receptor-G protein complex, offering exciting insights into how they function. All key tools of current membrane research are described, including detergents and model systems, bioinformatics, protein-folding methodology, crystallography and diffraction, and molecular modeling. This comprehensive and up-to-date text, emphasising the correlations between membrane research and human health, provides a solid foundation for all those working in this field.