Popular culture often equates testosterone with virility, strength, and the macho male physique. Viewed by some as an "antiaging tonic," testosterone's reputation and increased use by men of all ages in the United States have outpaced the scientific evidence about its potential benefits and risks. In particular there has been growing concern about an increase in the number of middle-aged and older men using testosterone and the lack of scientific data on the effect it may have on aging males. Studies of testosterone replacement therapy in older men have generally been of short duration, involving small numbers of participants and often lacking adequate controls. Testosterone and Aging weighs the options of future research directions, examines the risks and benefits of testosterone replacement therapy, assesses the potential public health impact of such therapy in the United States, and considers ethical issues related to the conduct of clinical trials. Testosterone therapy remains an attractive option to many men even as speculation abounds regarding its potential.

Praise for The Definitive Testosterone Replacement MANual "Inspiring is Jay's knowledge of hormone replacement and human physiology, which surpasses that of many of my medical colleagues. This he brings to you the reader in the pages of his much-needed and timely opus. Open your eyes, read and digest Jay's words. This book is the chapter that I was scared to write." Brett Osborn, MD Diplomate, American Board of Neurological Surgery Diplomate, American Academy of Anti-Aging Medicine CSCS, National Strength and Conditioning Association, Author of Get Serious, A Neurosurgeon's Guide To Optimal Health and Fitness "The Definitive Testosterone Replacement MANual presents practical information about the best ways to maximize benefits and minimize side effects of testosterone replacement therapy. It accomplishes this goal in the most visually appealing way I have ever seen in this field. This book makes for an enjoyable and highly empowering read for any man who wants to take charge of his health and quality of life." Nelson Vergel CEO, ExcelMale.com and DiscountedLabs.com, Author of Testosterone A Man's Guide: Practical Tips For Boosting Physical, Mental and Sexual Vitality Are You Living Life At Your Maximum Potential? Is your sex drive at its peak, or has it diminished? Is your enthusiasm for life lessening? Healthy testosterone levels are not only a physical state of prime health, but a mental state of positive wellness and aggression. A man with low testosterone will experience not only a physical decline, but also a diminished quality of life. Testosterone is often misrepresented by the media at large as inciting "hostility," or its effects are reduced down to building muscle only, and its portrayed as being detrimental to health. Nothing could be further from the truth. Comprehensive clinical evidence has unequivocally demonstrated that healthy testosterone levels not only slow the aging process and improve physical markers of health, but that they also reduce the possibility of degenerative disease, and by extension vastly improve quality of life. Men NEED Optimal Testosterone Levels to age powerfully and live to their maximum potential. The Definitive Testosterone Replacement Therapy MANual is the first book of its kind covering not only the therapeutic practice and application of TRT, but the historical, sociological, and biological issues that inform its usage. With this manual, you will learn: The history of testosterone, and the modern narrative that influences its use and prescriptionHow to assess your own testosterone levels, and make medically supported decisions at improving your hormonal healthThe science of TRT gathered from ample research data made understandable, and how it influences broad spectrumDiet, training, and lifestyle guidance that will support your revitalized way of living

New developments in testosterone therapy are summarized here by internationally renowned experts. They review both basic and clinical knowledge in fourteen chapters. The book begins with the biochemistry of testosterone, its biosynthesis, metabolism and mechanisms of action in target organs. Three chapters deal with specific aspects of testosterone action, namely its role in spermatogenesis, its psychotropic effects and its effects on bones. Syndromes caused by androgen resistance are described in order to highlight the importance of properly functioning enzymes and receptors in the target organs. Causes and symptoms of male hypogonadism, the major indication for testosterone treatment, are described. Five chapters are devoted to the pharmacology, pharmacokinetics and clinical uses and abuses of testosterone preparations. The new transdermal testosterone application is described in detail. Side effects of testosterone treatment are reviewed. The possible role of androgens in the development of prostatic hypertrophy and carcinoma is discussed extensively since this question is of major concern to the clinician.

PRAISE FOR THE TOT BIBLE: Every now and then a book is published that literally can and will change the trajectory of your life. This is a must read for the physician and the patient. The field of interventional endocrinology has advanced dramatically in the past decade exposing the numerous subtleties required for expert hormone replacement therapy. Jay has interviewed and assembled powerful insights into this field of endeavor, giving you, the reader, his years of expertise and authoritarian information that brings you to the pinnacle of TOT. Insights from numerous thought leaders with decades of clinical experience will educate, inform and enlighten. Welcome to the "Tip of the Spear"! Rob Kominiarek, DO, FACOFP, Founder ReNue HealthAre you aware of the worldwide crisis that's robbing men of their masculinity, their sex drive, and their enthusiasm for life as a whole?This is not scaremongering, nor is it a conspiracy theory - it's the cold hard truth. It's well-established that testosterone levels decrease by 1% a year after the age of 30, and up to 40% of grown adult men are dealing with low testosterone levels. And this is further compounded by all the pollution in our environment that messes up our hormones. The TOT Bible is jam-packed with cutting-edge, evidence-based information that incorporates the latest medical advancements and experience-based knowledge of the top progressive physicians, and is the ONLY reference for optimizing testosterone levels and male hormonal health!This book will teach you:●Why optimizing your testosterone is essential for helping your body function properly, and how it affects far more than your muscles or your physical strength.●How optimized levels of testosterone can help you reclaim your health, vitality, and masculinity.●Why obesity is so common in men with suboptimal levels of testosterone and how you can reduce body fat permanently.●The SHOCKING TRUTH about the nearly unavoidable lifestyle, health and environmental factors that negatively affect your testosterone levels.●High-performance nutrition, training, and body-mind-spirit strategies to take your life to the next level. ●The best treatment options that are currently available for the safe and productive use of therapeutic testosterone.●A complete scientific demolition of the mainstream myths and misconceptions surrounding the usage and demonization of therapeutic testosterone.●A painstakingly compiled list of game-changing supplements and medications - found nowhere else - that will completely alter your physique and enhance your mental performance.●Women's Hormonal Optimization Therapy (HOT) as practiced by a leading physician and a high achieving mother with five children - a hormonally balanced partner means a better relationship for you.If you're an average guy with average ambitions, then this book is not for you. This book is for men who want to become the BEST possible version of themselves and live an incredible life of optimal health and vitality.

While menopause in women is a well-established and well documented phenomenon, the andropause in men is a relatively new concept. The terms male menopauseand andropausesuggest that this is an abrupt phenomenon related to a sudden deprivation of sex hormones. Unlike the menopause, which has a relatively sudden onset, the andropause appears to be a gradual process. It has been hypothesized that an androgen deficiency might develop with aging. Androgens and the Aging Male explores this hypothesis. The book focuses on the gradually progressive problems related to the decline in androgens that can occur with advancement of age. It examines the debate about the extent to which an age-dependent decline in androgens leads to health problems that affect or impair the quality of life, and the theory behind it. In addition, it reviews studies evaluating the effects of androgen supplementation. Androgens and the Aging Male comprehensively covers androgen function and how it changes over time.

The decade that has passed since publication of the second edition of this textbook has not only witnessed a tremendous increase in knowledge within the ? eld of and- logy, but also seen the ? eld itself achieve a newfound status within the medical p- fession. Knowledge and status have been of mutual bene? t to the ? eld and the growing critical mass of diagnostic and therapeutic possibilities have caused andrology to be recognized as a medical subspecialty in some countries such as Germany, Poland, and Estonia. The European Academy of Andrology (EAA) served as a pacemaker for this development and continues to strive for establishment of andrology as a clinical ? eld. Well-designed curricula and qualifying examinations have contributed to the of? cial recognition of andrology as a speciality. This recognition of the ? eld helps patients with andrological problems to ? nd the specialist they seek. This textbook summarizes the current state of knowledge in the ? eld of andrology. It is a source of knowledge to all those who are or want to become andrologists. In addition, as andrology is clearly an interdisciplinary ? eld, this book may serve as a compendium and source of reference for all those physicians and biologists active in neighboring areas, who want to obtain an overview of andrology and who require information on special problems. The extensive references are timely and up to date.

"Dr. Morgentaler, an internationally recognized expert in sexual medicine and male hormones, shares his secrets for a healthy life." --Irwin Goldstein, M.D., Director of Sexual Medicine, Alvarado Hospital, San Diego, and Editor-in-Chief, Journal of Sexual Medicine "A highly valuable resource. Finally debunks many of the myths about testosterone's safety, which has been an impediment to its appropriate usage for far too long." --David E. Greenberg, M.D., President, Canadian Society for the Study of the Aging Male From a Harvard doctor and a leading expert on testosterone--the groundbreaking book that shows you how to raise your testosterone levels--and live your life to the fullest Better sex. Increased vitality. More muscle. Improved health. Greater mental agility. These are just a few of the life-enhancing benefits that men with low levels of testosterone can experience when they increase their testosterone level. If you've noticed a decrease in your sex drive; experienced erectile dysfunction; or felt tired, depressed, and unmotivated, this authoritative, up-to-date guide from an expert at Harvard Medical School will help you determine if you have low testosterone--a surprisingly common but frequently undiagnosed condition among middle-aged men. Learn how to: Recognize the symptoms of low testosterone Diagnose the problem with simple tests Find the treatment that's right for you Explore options your doctor might not know about Reduce your risk of cardiovascular disease and obesity