Tay-Sachs disease is a rare hereditary disease caused by a genetic mutation that leaves the body unable to produce an enzyme necessary for fat metabolism in nerve cells, producing central nervous system degeneration. In infants, it is characterized by progressive mental deterioration, blindness, paralysis, epileptic seizures, and death by age four. Adult-onset Tay-Sachs occurs in persons who have a genetic mutation that is similar but allows some production of the missing enzyme. There is no treatment for Tay-Sachs.A test to determine whether an infant is carrying the Tay-Sachs disease was introduced in 1969. However, work continues to be done to help find a cure. Because there is no cure for this deadly disease, genetic research is essential. Advances in Genetics presents an eclectic mix of articles of use to all human and molecular geneticists. They are written and edited by recognized leaders in the field and make this an essential series of books for anyone in the genetics field.

Describes the symptoms, diagnosis, treatment, and genetic aspects of Tay-Sachs disease.

Yvonne, the incurable snob. Ida, the ultimate goody two-shoes. Haki, the brilliant master of sarcastic wit. Doris, the terminally stingy athlete. Maisha, the "BBC." Tay. They are the Form 1A's at St. Claire's, and top students from all over Kenya. Some come from the remotest rural villages, others from the biggest mansions in the most exclusive neighborhoods of the capital city; others still are from the worst city slums. Under the watchful eye of Sister Marian the headmistress, the eternal punishments of "Terror Mama," the deputy headmistress, and the kindness of their favorite teacher Ms. Sashi, everyone gets along fine... or do they? There is that one club that some students are unable to join... the unbelievable prefect elections... there is also the house competitions business... Something is not quite right. What can Tay do about it?

In May 1970, aerial photographs revealed what U.S. military intelligence believed was a POW camp near the town of Son Tay, twenty-three miles west of North Vietnam’s capital city. When American officials decided the prisoners were attempting to send signals, they set in motion a daring plan to rescue the more than sixty airmen thought to be held captive. On November 20, a joint group of volunteers from U.S. Army Green Berets and U.S. Air Force Special Operations Forces perfectly executed the raid, only to find the prisoners' quarters empty; the POWs had been moved to a different location. Initially, the Son Tay raid was a devastating disappointment to the men who risked their lives to carry it out. Many vocal critics labeled it as a spectacular failure of our nation’s intelligence network. However, subsequent events proved that the audacity of the rescue attempt stunned the North Vietnamese, who implemented immediate changes in the treatment of their captives. The operation also restored the prisoners’ faith that their nation had not forgotten them. John Gargus not only participated in the planning phase of the Son Tay rescue, but also flew as a lead navigator for the strike force. This revised edition incorporates the most recent information from raid participants and also includes recent translations of North Vietnamese perspectives. No previous account of this top-secret action has given such a full account or such insight into both the execution and the aftermath of Son Tay.

This dedicated volume of texts is a celebration of Alice E. S. Tay and her work. There is overwhelming evidence in these texts that the body of work that has been amassed by Professor Tay is extraordinary. As is documented in this volume, her work can be described, listed, enumerated in dates and data, counted in publictions and extolled as enriching, even empowering, personal experiences by her students, colleagues and allies - often forging a relationship for a lifetime. Contents Klaus A. Ziegert: AEST - an Attempt at Explaining the Phenomenon Murray Gleeson: A Tribute to Professor Alice Tay Julia Horn: The Making of an Intellectual Kim Santow: Preface for the Festschrift of AEST List of Publications of Alice Erh-Soon Tay.

"George Dutton has written the first detailed Western-language study of the Tây So’n movement, which permanently altered Vietnam’s political trajectory. But in so doing, he also provides a sensitive social and cultural analysis of the pre-1800 Vietnamese-speaking world as a whole, and indeed one of the most detailed descriptions of any late 18th-century society in Southeast Asia." —Victor Lieberman, University of Michigan "It is difficult to overstate the significance of George Dutton’s terrific new book. The Tây So’n Uprising represents the first serious western-language account of the intricate sequence of political developments that define the Tây So’n era and that arguably mark the onset of modernity in Vietnam. In addition to providing a vividly evocative narrative of the complex political history of the period, Dutton offers lucid and judicious interpretations of the origins, evolution and downfall of the uprising and of its consequences for a wide range of social groups, political forces and ethnic communities. The level of research and historical craftsmanship is superb, and Dutton’s frequent reflections on relevant theoretical and historiographical issues make for fascinating reading. In short, this is a stunning accomplishment and a major contribution to the study of Vietnamese history and historiography." —Peter Zinoman, University of California, Berkeley The Tây So’n uprising (1771–1802) was a cataclysmic event that profoundly altered the eighteenth-century Vietnamese political and social landscape. This groundbreaking book offers a new look at an important and controversial era. George Dutton follows three brothers from the hamlet of Tây So’n as they led a heterogeneous military force that ousted ruling families in both halves of the divided Vietnamese territories and eventually toppled the 350-year-old Lè dynasty. Supplementing Vietnamese primary sources with extensive use of archival European missionary accounts, he explores the dynamics of an event that affected every region of the country and every level of society. Tracing the manner in which the Tây So’n leaders transformed an inchoate uprising into a new political regime, Dutton challenges common depictions of the Tây So’n brothers as visionaries or revolutionaries. Instead, he reveals them as political opportunists whose worldview remained constrained by their provincial origins and the exigencies of ongoing warfare and political struggles.

Tay is trying to settle into his new life with a group of strangers who call themselves his family. Even Willow has deserted him. Then he meets Wisp, and things look up – until a shadow assassin attempts to kill him, Cale traps his shadow in a gem and the only way to save him appears to be a mad wizard. What can possibly top all that? Meeting a hundred-thousand-year-old king and his dragon friend, the very dragon on whom the entire city is built.