Targeting the Microenvironment Niche in Solid and Hematologic Malignancies: Basic and Translational Research
Title | Targeting the Microenvironment Niche in Solid and Hematologic Malignancies: Basic and Translational Research PDF eBook |
Author | Cirino Botta |
Publisher | Frontiers Media SA |
Pages | 163 |
Release | 2022-02-28 |
Genre | Medical |
ISBN | 2889745414 |
Targeting the Microenvironment Niche in Hematologic Malignancies
Title | Targeting the Microenvironment Niche in Hematologic Malignancies PDF eBook |
Author | Cirino Botta |
Publisher | Frontiers Media SA |
Pages | 193 |
Release | 2022-02-02 |
Genre | Medical |
ISBN | 2889742679 |
Targeting the Microenvironment Niche in Solid Tumors
Title | Targeting the Microenvironment Niche in Solid Tumors PDF eBook |
Author | Cirino Botta |
Publisher | Frontiers Media SA |
Pages | 155 |
Release | 2022-04-29 |
Genre | Medical |
ISBN | 2889747727 |
Overcoming Physiologic Barriers to Treatments for Hematologic Malignancies by Molecularly Targeting the Tumor Microenvironment
Title | Overcoming Physiologic Barriers to Treatments for Hematologic Malignancies by Molecularly Targeting the Tumor Microenvironment PDF eBook |
Author | Qin Wang |
Publisher | Frontiers Media SA |
Pages | 109 |
Release | 2024-01-29 |
Genre | Science |
ISBN | 283254360X |
Hematologic malignancies (HMs) represent a group of hematologic cancers originating from bone marrow or lymphoid organs. Currently, leukaemia, lymphoma, and multiple myeloma are the most common HMs. Conventional treatments for HMs include bone marrow transplantation, radiotherapy, chemotherapy, and immunotherapy. Despite the significant achievements obtained over the past decade in the drug therapy of HMs, tumor metastasis and relapse in patients often occurred after an initial response, indicating the generation of drug resistance to current therapies. Moreover, many clinically used therapeutic drugs are often associated with dose-related side effects and a lack of specificity to tumor tissues. The tumor microenvironment (TME) in HMs consists of a complicated network of cellular interactions and signaling cross-talking within the bone marrow cavity, and it plays an essential role in the progression and metastasis of HM. Furthermore, the TME in HMs has formed physiologic barriers such as immunosuppressive microenvironment, upregulated anti-apoptotic system, drug resistance, etc. to facilitate drug resistance and relapse of HMs. It has become widely accepted that effective treatment against HMs may require targeting both the cancer cell and TME.
Stem Cells – From Hype to Real Hope
Title | Stem Cells – From Hype to Real Hope PDF eBook |
Author | Khawaja Husnain Haider |
Publisher | Walter de Gruyter GmbH & Co KG |
Pages | 340 |
Release | 2018-12-17 |
Genre | Medical |
ISBN | 3110586916 |
This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled "Stem Cells: from Drug to Drug Discovery" which was published in 2017.
The Cancer Stem Cell Niche
Title | The Cancer Stem Cell Niche PDF eBook |
Author | Susie Nilsson |
Publisher | Academic Press |
Pages | 246 |
Release | 2021-02-09 |
Genre | Science |
ISBN | 0323853250 |
The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone and their roles in cancer metastasis, The role of vasculature in cancer stem cell niches, The lung cancer stem cell niche, The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches, Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression, The testicular cancer stem cell niche. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Stem Cells and their Niches series Includes the latest information on the Cancer Stem Cell Niche
Medical Reviews Selected Bibliography 2011 November
Title | Medical Reviews Selected Bibliography 2011 November PDF eBook |
Author | |
Publisher | |
Pages | 120 |
Release | |
Genre | |
ISBN | 3944619005 |