This textbook for graduate students in statistics, data science, and public health deals with the practical challenges that come with big, complex, and dynamic data. It presents a scientific roadmap to translate real-world data science applications into formal statistical estimation problems by using the general template of targeted maximum likelihood estimators. These targeted machine learning algorithms estimate quantities of interest while still providing valid inference. Targeted learning methods within data science area critical component for solving scientific problems in the modern age. The techniques can answer complex questions including optimal rules for assigning treatment based on longitudinal data with time-dependent confounding, as well as other estimands in dependent data structures, such as networks. Included in Targeted Learning in Data Science are demonstrations with soft ware packages and real data sets that present a case that targeted learning is crucial for the next generation of statisticians and data scientists. Th is book is a sequel to the first textbook on machine learning for causal inference, Targeted Learning, published in 2011. Mark van der Laan, PhD, is Jiann-Ping Hsu/Karl E. Peace Professor of Biostatistics and Statistics at UC Berkeley. His research interests include statistical methods in genomics, survival analysis, censored data, machine learning, semiparametric models, causal inference, and targeted learning. Dr. van der Laan received the 2004 Mortimer Spiegelman Award, the 2005 Van Dantzig Award, the 2005 COPSS Snedecor Award, the 2005 COPSS Presidential Award, and has graduated over 40 PhD students in biostatistics and statistics. Sherri Rose, PhD, is Associate Professor of Health Care Policy (Biostatistics) at Harvard Medical School. Her work is centered on developing and integrating innovative statistical approaches to advance human health. Dr. Rose’s methodological research focuses on nonparametric machine learning for causal inference and prediction. She co-leads the Health Policy Data Science Lab and currently serves as an associate editor for the Journal of the American Statistical Association and Biostatistics.

The statistics profession is at a unique point in history. The need for valid statistical tools is greater than ever; data sets are massive, often measuring hundreds of thousands of measurements for a single subject. The field is ready to move towards clear objective benchmarks under which tools can be evaluated. Targeted learning allows (1) the full generalization and utilization of cross-validation as an estimator selection tool so that the subjective choices made by humans are now made by the machine, and (2) targeting the fitting of the probability distribution of the data toward the target parameter representing the scientific question of interest. This book is aimed at both statisticians and applied researchers interested in causal inference and general effect estimation for observational and experimental data. Part I is an accessible introduction to super learning and the targeted maximum likelihood estimator, including related concepts necessary to understand and apply these methods. Parts II-IX handle complex data structures and topics applied researchers will immediately recognize from their own research, including time-to-event outcomes, direct and indirect effects, positivity violations, case-control studies, censored data, longitudinal data, and genomic studies.

Data analysis is changing fast. Driven by a vast range of application domains and affordable tools, machine learning has become mainstream. Unsupervised data analysis, including cluster analysis, factor analysis, and low dimensionality mapping methods continually being updated, have reached new heights of achievement in the incredibly rich data wor

This monograph uses the Julia language to guide the reader through an exploration of the fundamental concepts of probability and statistics, all with a view of mastering machine learning, data science, and artificial intelligence. The text does not require any prior statistical knowledge and only assumes a basic understanding of programming and mathematical notation. It is accessible to practitioners and researchers in data science, machine learning, bio-statistics, finance, or engineering who may wish to solidify their knowledge of probability and statistics. The book progresses through ten independent chapters starting with an introduction of Julia, and moving through basic probability, distributions, statistical inference, regression analysis, machine learning methods, and the use of Monte Carlo simulation for dynamic stochastic models. Ultimately this text introduces the Julia programming language as a computational tool, uniquely addressing end-users rather than developers. It makes heavy use of over 200 code examples to illustrate dozens of key statistical concepts. The Julia code, written in a simple format with parameters that can be easily modified, is also available for download from the book’s associated GitHub repository online. See what co-creators of the Julia language are saying about the book: Professor Alan Edelman, MIT: With “Statistics with Julia”, Yoni and Hayden have written an easy to read, well organized, modern introduction to statistics. The code may be looked at, and understood on the static pages of a book, or even better, when running live on a computer. Everything you need is here in one nicely written self-contained reference. Dr. Viral Shah, CEO of Julia Computing: Yoni and Hayden provide a modern way to learn statistics with the Julia programming language. This book has been perfected through iteration over several semesters in the classroom. It prepares the reader with two complementary skills - statistical reasoning with hands on experience and working with large datasets through training in Julia.

Focuses on mathematical understanding Presentation is self-contained, accessible, and comprehensive Full color throughout Extensive list of exercises and worked-out examples Many concrete algorithms with actual code

This book covers the topic of data science in a comprehensive manner and synthesizes both fundamental and advanced topics of a research area that has now reached its maturity. The book starts with the basic concepts of data science. It highlights the types of data and their use and importance, followed by a discussion on a wide range of applications of data science and widely used techniques in data science. Key Features • Provides an internationally respected collection of scientific research methods, technologies and applications in the area of data science. • Presents predictive outcomes by applying data science techniques to real-life applications. • Provides readers with the tools, techniques and cases required to excel with modern artificial intelligence methods. • Gives the reader a variety of intelligent applications that can be designed using data science and its allied fields. The book is aimed primarily at advanced undergraduates and graduates studying machine learning and data science. Researchers and professionals will also find this book useful.

This book is a practical guide to problems that commonly arise when developing a machine learning project. The book's topics are: Exploratory data analysis Data Preparation Selecting best variables Assessing Model Performance More information on predictive modeling will be included soon. This book tries to demonstrate what it says with short and well-explained examples. This is valid for both theoretical and practical aspects (through comments in the code). This book, as well as the development of a data project, is not linear. The chapters are related among them. For example, the missing values chapter can lead to the cardinality reduction in categorical variables. Or you can read the data type chapter and then change the way you deal with missing values. You¿ll find references to other websites so you can expand your study, this book is just another step in the learning journey. It's open-source and can be found at http://livebook.datascienceheroes.com