Sulfonamides are the commonly used antibiotics, which are used in the combination with other antibiotics to enhance their effect. They are absorbed in the intestine and are widely distributed into the tissues. Sulfonamides inhibit the growth of bacteria by reverse inhibition and block the cycle of folic acid synthesis while they are effective against only those bacteria which produce folic acid intracellular. This book discusses about the synthesis of sulfonamides their characterization with modern instruments and their importance. The antibacterial activity which increases their importance has also been discussed. This book is divided into different chapters which enables the readers to understand this book easily. Chapter 1 covers the general introduction of sulfonamides and techniques used for characterization and chapter 2 explains the previous scientific work done on sulfonamides. Chapter 3 contains the experimental work while chapter 4 discusses the results obtained. Figures, tables and schemes are used to make it easier for readers.

"Several decades after the great discovery of antibiotics, scientists recognized the ability of bacteria and other microbes to resist antibiotics. Gram-nagative bacteria are able to produce and enzyme known as Beta-lactamases, which are destroying Beta-lactum antibiotics able to make them reisitant to antibiotics. A particular group of thiazole sulfonamides with extended ring structures attached to a sulfonamide group, inhibit Beta-lactamase. The present research synthesizes novel thiazole derivatives using multi-component microwave reactions and evaluates their activity against resistant microbial agents. Results described in this research discussed compound extraction, purification and characterization using various methods such as: liquid chromatography seperation (Biotage), thin layer chromatography, liquid extraction, rotary evaporation and Nuclear magnetic resonance (NMR) analysis. Newly synthesized and purified compounds were evaluated in microbiological assays using the Kirby-Bauer protocol to assess bacterial growth inhibition." --From page i

Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful and theoretically complex analytical tool. Basic 1H- and 13C-NMR Spectroscopy provides an introduction to the principles and applications of NMR spectroscopy. Whilst looking at the problems students encounter when using NMR spectroscopy, the author avoids the complicated mathematics that are applied within the field. Providing a rational description of the NMR phenomenon, this book is easy to read and is suitable for the undergraduate and graduate student in chemistry. Describes the fundamental principles of the pulse NMR experiment and 2D NMR spectra Easy to read and written with the undergraduate and graduate chemistry student in mind Provides a rational description of NMR spectroscopy without complicated mathematics

Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions, Sixteenth Edition, Seven Volume Set builds on the success of the 15 previous editions, providing an extensively reorganized and expanded resource that now comprises more than 1,500 individual drug articles with the most complete coverage of adverse reactions and interactions found anywhere. Each article contains detailed and authoritative information about the adverse effects of each drug, with comprehensive references to the primary literature, making this a must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company. The online version of the book provides an unparalleled depth of coverage and functionality by offering convenient desktop access and enhanced features such as increased searchability, extensive internal cross-linking, and fully downloadable and printable full-text, HTML or PDF articles. Enhanced encyclopedic format with drug monographs now organized alphabetically Completely expanded coverage of each drug, with more than 1,500 drug articles and information on adverse reactions and interactions Clearer, systematic organization of information for easier reading, including case histories to provide perspective on each listing Extensive bibliography with over 40,000 references A must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company

The goal of an activity-directed isolation process is to isolate bioactive compounds which may provide structural leads of therapeutic importance. Whereas the traditional process of drug development is long and expensive, simple and rapid bioassays can serve as the starting point for drug discovery. This book presents a range of "bench top" bioassa

Antimicrobial Resistance in Agriculture: Perspective, Policy and Mitigation is a valuable industrial resource that addresses complex, multi-factorial topics regarding farm, wild, companion animals, fish, and how the environment plays an important role in amplification and transmission of resistant bugs into the human food chain. Information of phenotypical and genotypical properties of each bacterial genus associated with antimicrobial resistance, transmission dynamics from different reservoirs (food animals, poultry, fishes) and control measures with alternative therapy, such as phytobiotics and nanomaterials are provided. Researchers, scientists and practitioners will find this an essential resource on the judicial use of antibiotics in animals and humans. Explores all the genera of livestock and fish originated pathogenic bacteria associated with antimicrobial resistance Presents cutting-edge research on epigenetics, nanotechnology and intervention technologies Discusses transmission dynamics of resistance gene pools from different reservoirs, including food animals, poultry, fishes and the environment