This book, which is the third volume of Biomedical translational research, focuses on the fundamental role of biomedical research in developing new medicinal products. It emphasizes the importance of understanding biological and pathophysiological mechanisms underlying the disease to discover and develop new biological agents. The book uniquely explores the genomic computational integrative approach for drug repositioning. Further, it discusses the health benefits of nutraceuticals and their application in human diseases. Further, the book comprehensively reviews different computational approaches that employ GWAS data to guide drug repositioning. Finally, it summarizes the major challenges in drug development and the strategies for the rational design of the next generation more effective but less toxic therapeutic agents.

This unique volume presents the recent advances in tissue regeneration. The authors are all active researchers in their respective fields with extensive experiences. The focus of the book is on the use of stem cells and nano-structured biomaterials for tissue regeneration/tissue engineering. It includes the use of stem cells, naturally derived extracellular matrix (ECM), synthetic biomimetic nano-fibers, synthetic nano-structured ceramics and synthetic nano-structured polymer/ceramic composites that can help/promote tissue regeneration. Methods on how to produce these nano-structured biomaterials are also discussed in several chapters. Future challenges and perspectives in the field of regenerative medicine (tissue regeneration) are also discussed.

Handbook of Ionic Substituted Hydroxyapatites provides scientists and researchers with comprehensive information on the synthesis processes of hydroxyapatite, also explaining the application of substituted hydroxyapatite. The book's content is very structured and explanatory, starting with a detailed overview of biological apatite in bones and teeth, as well as a presentation of the analytical tools for hydroxyapatite. Bioceramics and the relative modern and emerging processing techniques are covered, as is 3-D printing, which has gained increasing importance within biomedical materials and in the use of hydroxyapatite in tissue engineering. Finally, the advantages and disadvantages of using ionic substitutions in clinical application are presented. Students and researchers in disciplines, such as Material Science, Ceramics, and Bioengineering will find this book to be very helpful in their work. It will also be a valuable resource for practitioners and surgeons in orthopedics, perio/implantology and maxillo-facial disciplines, and professionals working in R&D in ceramics and pharmaceuticals. - Provides responses to the lack of scientific information about hydroxyapatites for biomedical applications - Solves researchers' issues regarding phase changes with respect to substituted ions and how these substitutions can alter/improve the properties of stoichiometric hydroxyapatite - Explains modern clinical applications and the effects of apatites within biomedical applications - Includes both the advantages and disadvantages of using ionic substitutions in clinical application

In my second work, I improved mechanical performance of HAp (Ca10(PO4)6(OH)2 by reducing particle-size of the powder through the synthesis of stoichiometric, nanocrystalline, single phase HAp powder in the range of 2-20 nm. Synthesis of powder was accomplished via a modified low temperature sol-gel technique using ethanol/ water as solvent.

Biomedical Materials and Diagnostics Devices provides an up-to-date overview of the fascinating and emerging field of biomedical materials and devices, fabrication, performance, and uses The biomedical materials with the most promising potential combine biocompatibility with the ability to adjust precisely the biological phenomena in a controlled manner. The world market for biomedical and diagnostic devices is expanding rapidly and the pace of academic research resulted in about 50,000 published papers in recent years. It is timely, therefore, to assemble a volume on this important subject. The chapters in the book seek to address progress in successful design strategies for biomedical materials and devices such as the use of collagen, crystalline calcium orthophosphates, amphiphilic polymers, polycaprolactone, biomimetic assembly, bio-nanocomposite matrices, bio-silica, theranostic nanobiomaterials, intelligent drug delivery systems, elastomeric nanobiomaterials, electrospun nano-matrices, metal nanoparticles, and a variety of biosensors. This large and comprehensive volume includes twenty chapters authored by some of the leading researchers in the field, and is divided into four main areas: biomedical materials; diagnostic devices; drug delivery and therapeutics; and tissue engineering and organ regeneration.