Characterization of Polymeric Biomaterials presents a comprehensive introduction on the topic before discussing the morphology and surface characterization of biomedical polymers. The structural, mechanical, and biological characterization is described in detail, followed by invaluable case studies of polymer biomaterial implants. With comprehensive coverage of both theoretical and experimental information, this title will provide scientists with an essential guide on the topic of these materials which are regularly used for clinical applications, such as implants and drug delivery devices. However, a range of novel polymers and the development and modification of existing medical polymers means that there is an ongoing need to satisfy particular design requirements. This book explains the critical and fundamentals methods to characterize polymer materials for biomedical applications. - Presents a self-contained reference on the characterization of polymeric biomaterials - Provides comprehensive information on how to characterize biomedical polymers in order to improve design and synthesis - Includes useful case studies that demonstrate the characterization of biomaterial implants

In joint replacement surgery with suboptimal bone, allograft materials are often used to achieve biological fixation of the metallic implant to the host bone and reducing the implant fixation time. The most commonly used techniques are cemented and hydroxyapatite (HA)-coated metallic implants. Typically, HA coatings are suggested for patients with better bone stock, whereas recommended implant fixation process for most other osteoporotic patients is bone cements. In general, there is a long-standing need to improve the performance of hip and other devices for longer in vivo implant lifetime that can help in reducing the number of revision surgeries, as well as minimizing physical and mental trauma to the patient. To achieve these goals, it is important to understand the mechanical and biological properties of coatings that can influence not only its short- and long-term bioactivity but also life span in vivo. Over the years, it has been recognized that the stability of a coated implant is governed by its physical and mechanical properties. A coating that separates from the implant provides no advantage over an uncoated implant and undesirable due to problems with debris materials, which can lead to osteolysis. Therefore, it is important to properly characterize the coated implants in terms of its physical and mechanical properties. In this chapter, specific details on coating characterization techniques including sample dimensions, sample preparation, experimental procedure and data interpretation are discussed. In particular, the standards and requirements of regulatory organizations are presented elucidating the significance and use of each characterization. It is important to appreciate that mechanical properties of coatings can only be determined with certain coating specification such as coating thickness. This chapter is designed even for non-experts to follow mechanical property characterizations of coatings on medical implants.

This book aims to summarize the latest achievements in the development and manufacturing of modern biomaterials used in modern medicine and dentistry, for example, in cases where, as a result of a traffic or sports accident, aging, resection of organs after oncological surgery, or dangerous inflammation, there is a need to replace lost organs, tissues, and parts of the human body. The essence of biomedical materials is their constant contact with living tissues, organisms, or microorganisms and, therefore, they should meet numerous requirements from various fields, including medicine, biology, chemistry, tissue engineering, and materials science. For this reason, biomaterials must be compatible with the organism, and biocompatibility issues must be addressed before using the product in a clinical setting. The production and synthesis of biomaterials require the use of various technologies and methods to obtain the appropriate material, which is then processed using advanced material processing technologies. Often, however, it is necessary to directly manufacture a specific product with individualized geometric features and properties tailored to the requirements of a particular patient. In such cases, additive manufacturing methods are increasingly used. In this sense, it can be considered that the Biomaterials 4.0 stage has been reached, and detailed information is included in the individual chapters of this book on the achievements in the development and manufacturing of modern biomaterials used in modern regenerative medicine, regenerative dentistry, and tissue engineering.

Polymers are important and attractive biomaterials for researchers and clinical applications due to the ease of tailoring their chemical, physical and biological properties for target devices. Due to this versatility they are rapidly replacing other classes of biomaterials such as ceramics or metals. As a result, the demand for biomedical polymers has grown exponentially and supports a diverse and highly monetized research community. Currently worth $1.2bn in 2009 (up from $650m in 2000), biomedical polymers are expected to achieve a CAGR of 9.8% until 2015, supporting a current research community of approximately 28,000+. Summarizing the main advances in biopolymer development of the last decades, this work systematically covers both the physical science and biomedical engineering of the multidisciplinary field. Coverage extends across synthesis, characterization, design consideration and biomedical applications. The work supports scientists researching the formulation of novel polymers with desirable physical, chemical, biological, biomechanical and degradation properties for specific targeted biomedical applications. - Combines chemistry, biology and engineering for expert and appropriate integration of design and engineering of polymeric biomaterials - Physical, chemical, biological, biomechanical and degradation properties alongside currently deployed clinical applications of specific biomaterials aids use as single source reference on field. - 15+ case studies provides in-depth analysis of currently used polymeric biomaterials, aiding design considerations for the future

A practical handbook rather than merely a chemistry reference, Szycher's Handbook of Polyurethanes, Second Edition offers an easy-to-follow compilation of crucial new information on polyurethane technology, which is irreplaceable in a wide range of applications. This new edition of a bestseller is an invaluable reference for technologists, marketers, suppliers, and academicians who require cutting-edge, commercially valuable data on the most advanced uses for polyurethane, one of the most important and complex specialty polymers. internationally recognized expert Dr. Michael Szycher updates his bestselling industry "bible" With seven entirely new chapters and five that are revised and updated, this book summarizes vital contents from U.S. patent literature—one of the most comprehensive sources of up-to-date technical information. These patents illustrate the most useful technology discovered by corporations, universities, and independent inventors. Because of the wealth of information they contain, this handbook features many full-text patents, which are carefully selected to best illustrate the complex principles involved in polyurethane chemistry and technology. Features of this landmark reference include: Hundreds of practical formulations Discussion of the polyurethane history, key terms, and commercial importance An in-depth survey of patent literature Useful stoichiometric calculations The latest "green" chemistry applications A complete assessment of medical-grade polyurethane technology Not biased toward any one supplier’s expertise, this special reference uses a simplified language and layout and provides extensive study questions after each chapter. It presents rich technical and historical descriptions of all major polyurethanes and updated sections on medical and biological applications. These features help readers better understand developmental, chemical, application, and commercial aspects of the subject.

Most current applications of biomaterials involve structural functions, even in those organs and systems that are not primarily structural in their nature, or very simple chemical or electrical functions. Complex chemical functions, such as those of the liver, and complex electrical or electrochemical functions, such as those of the brain and sense

Nanobiomaterials: Nanostructured materials for biomedical applications covers an extensive range of topics related to the processing, characterization, modeling, and biomedical applications of nanostructured ceramics, polymers, metals, composites, self-assembled materials, and macromolecules. Novel approaches for bottom-up and top-down processing of nanostructured biomaterials are highlighted. In addition, innovative techniques for characterizing the in vitro behavior and in vivo behavior of nanostructured biomaterials are considered. Applications of nanostructured biomaterials in dentistry, drug delivery, medical diagnostics, surgery and tissue engineering are examined. - Provides a concise description of the materials and technologies used in the development of nanostructured biomaterials - Provides industrial researchers with an up-to-date and handy reference on current topics in the field of nanostructured biomaterials - Includes an integrated approach that is used to discuss both the biological and engineering aspects of nanostructured biomaterials