In 1996 Joseph LeDoux's The Emotional Brain presented a revelatory examination of the biological bases of our emotions and memories. Now, the world-renowned expert on the brain has produced with a groundbreaking work that tells a more profound story: how the little spaces between the neurons—the brain's synapses—are the channels through which we think, act, imagine, feel, and remember. Synapses encode the essence of personality, enabling each of us to function as a distinctive, integrated individual from moment to moment. Exploring the functioning of memory, the synaptic basis of mental illness and drug addiction, and the mechanism of self-awareness, Synaptic Self is a provocative and mind-expanding work that is destined to become a classic.

In 1996 Joseph LeDoux's The Emotional Brain presented a revelatory examination of the biological bases of our emotions and memories. Now, the world-renowned expert on the brain has produced with a groundbreaking work that tells a more profound story: how the little spaces between the neurons—the brain's synapses—are the channels through which we think, act, imagine, feel, and remember. Synapses encode the essence of personality, enabling each of us to function as a distinctive, integrated individual from moment to moment. Exploring the functioning of memory, the synaptic basis of mental illness and drug addiction, and the mechanism of self-awareness, Synaptic Self is a provocative and mind-expanding work that is destined to become a classic.

Longlisted for the PEN/E.O. Wilson Literary Science Writing Award A leading neuroscientist offers a history of the evolution of the brain from unicellular organisms to the complexity of animals and human beings today Renowned neuroscientist Joseph LeDoux digs into the natural history of life on earth to provide a new perspective on the similarities between us and our ancestors in deep time. This page-turning survey of the whole of terrestrial evolution sheds new light on how nervous systems evolved in animals, how the brain developed, and what it means to be human. In The Deep History of Ourselves, LeDoux argues that the key to understanding human behavior lies in viewing evolution through the prism of the first living organisms. By tracking the chain of the evolutionary timeline he shows how even the earliest single-cell organisms had to solve the same problems we and our cells have to solve each day. Along the way, LeDoux explores our place in nature, how the evolution of nervous systems enhanced the ability of organisms to survive and thrive, and how the emergence of what we humans understand as consciousness made our greatest and most horrendous achievements as a species possible.

This solid introduction uses the principles of physics and the tools of mathematics to approach fundamental questions of neuroscience.

“A rigorous, in-depth guide to the history, philosophy, and scientific exploration of this widespread emotional state . . . [LeDoux] offers a magisterial review of the role of mind and brain in the generation of unconscious defense responses and consciously expressed anxiety. . . . [His] charming personal asides give an impression of having a conversation with a world expert.” —Nature A comprehensive and accessible exploration of anxiety, from a leading neuroscientist and the author of Synaptic Self Collectively, anxiety disorders are our most prevalent psychiatric problem, affecting about forty million adults in the United States. In Anxious, Joseph LeDoux, whose NYU lab has been at the forefront of research efforts to understand and treat fear and anxiety, explains the range of these disorders, their origins, and discoveries that can restore sufferers to normalcy. LeDoux’s groundbreaking premise is that we’ve been thinking about fear and anxiety in the wrong way. These are not innate states waiting to be unleashed from the brain, but experiences that we assemble cognitively. Treatment of these problems must address both their conscious manifestations and underlying non-conscious processes. While knowledge about how the brain works will help us discover new drugs, LeDoux argues that the greatest breakthroughs may come from using brain research to help reshape psychotherapy. A major work on one of our most pressing mental health issues, Anxious explains the science behind fear and anxiety disorders. Praise for Anxious: “[Anxious] helps to explain and prevent the kinds of debilitating anxieties all of us face in this increasingly stressful world.” —Daniel J. Levitin, author of The Organized Mind and This Is Your Brain on Music “A careful tour through the current neuroscience of fear and anxiety . . . [Anxious] will reward the informed reader.” —The Wall Street Journal “An extraordinarily ambitious, provocative, challenging, and important book. Drawing on the latest research in neuroscience (including work in his own laboratory), LeDoux provides explanations of the origins, nature, and impact of fear and anxiety disorders.” —Psychology Today

In this book the author has collected a number of his important works and added an extensive commentary relating his ideas to those of other prominentnames in the consciousness debate. The view presented here is that of a convinced dualist who challenges in a lively and humorous way the prevailing materialist "doctrines" of many recent works. Also included is a new attempt to explain mind-brain interaction via a quantum process affecting the release of neurotransmitters. John Eccles received a knighthood in 1958 and was awarded the Nobel Prize for Medicine/Physiology in 1963. He has numerous other awards honouring his major contributions to neurophysiology.

It is widely recognized that the neural basis of brain function can be fully understood only by integrating many disciplines at many levels. Studies of synaptic organization are bringing about a quiet revolution in achieving this goal, as documented by this unique book over the past 30 years. In this fifth edition, the results of the mouse and human genome projects are incorporated for the first time. Molecular biologists interested in functional genomics and proteomics of the brain will find answers here to the critical questions: what are the cell and circuit functions of gene products? Also for the first time, the reader is oriented to supporting neuroscience databases. Among the new advances covered are 2-photon confocal laser microscopy of dendrites and dendritic spines, biochemical analyses, and dual patch and multielectrode recordings, applied together with an increasing range of behavioral and gene-targeting methods. Leading experts in the best understood brain regions bring together the molecular, anatomical, functional, and behavioral data in authoritative integrated accounts. The chapters are organized in the same format, covering the neural elements, synaptic connections, basic circuits, physiology, neurotransmitters, neuromodulators, membrane properties, dendritic properties, and with a final section on how the circuits mediate specific behaviors. The uniform framework for each chapter enables the authors to higlight the principles that are common to all regions, as well as the adaptations unique to each, thus serving as a model for understanding the neural basis of behavior.