In the period just prior to medicine's modernity—before the rise of Renaissance anatomy, the centralized regulation of medical practice, and the valorization of scientific empiricism—England was the scene of a remarkable upsurge in medical writing. Between the arrival of the Black Death in 1348 and the emergence of printed English books a century and a quarter later, thousands of discrete medical texts were copied, translated, and composed, largely for readers outside universities. These widely varied texts shared a model of a universe crisscrossed with physical forces and a picture of the human body as a changeable, composite thing, tuned materially to the world's vicissitudes. According to Julie Orlemanski, when writers like Geoffrey Chaucer, Robert Henryson, Thomas Hoccleve, and Margery Kempe drew on the discourse of phisik—the language of humors and complexions, leprous pustules and love sickness, regimen and pharmacopeia—they did so to chart new circuits of legibility between physiology and personhood. Orlemanski explores the texts of her vernacular writers to show how they deployed the rich terminology of embodiment and its ailments to portray symptomatic figures who struggled to control both their bodies and the interpretations that gave their bodies meaning. As medical paradigms mingled with penitential, miraculous, and socially symbolic systems, these texts demanded that a growing number of readers negotiate the conflicting claims of material causation, intentional action, and divine power. Examining both the medical writings of late medieval England and the narrative and poetic works that responded to them, Symptomatic Subjects illuminates the period's conflicts over who had the authority to construe bodily signs and what embodiment could be made to mean.

In the period just prior to medicine's modernity—before the rise of Renaissance anatomy, the centralized regulation of medical practice, and the valorization of scientific empiricism—England was the scene of a remarkable upsurge in medical writing. Between the arrival of the Black Death in 1348 and the emergence of printed English books a century and a quarter later, thousands of discrete medical texts were copied, translated, and composed, largely for readers outside universities. These widely varied texts shared a model of a universe crisscrossed with physical forces and a picture of the human body as a changeable, composite thing, tuned materially to the world's vicissitudes. According to Julie Orlemanski, when writers like Geoffrey Chaucer, Robert Henryson, Thomas Hoccleve, and Margery Kempe drew on the discourse of phisik—the language of humors and complexions, leprous pustules and love sickness, regimen and pharmacopeia—they did so to chart new circuits of legibility between physiology and personhood. Orlemanski explores the texts of her vernacular writers to show how they deployed the rich terminology of embodiment and its ailments to portray symptomatic figures who struggled to control both their bodies and the interpretations that gave their bodies meaning. As medical paradigms mingled with penitential, miraculous, and socially symbolic systems, these texts demanded that a growing number of readers negotiate the conflicting claims of material causation, intentional action, and divine power. Examining both the medical writings of late medieval England and the narrative and poetic works that responded to them, Symptomatic Subjects illuminates the period's conflicts over who had the authority to construe bodily signs and what embodiment could be made to mean.

In the period just prior to medicine's modernity—before the rise of Renaissance anatomy, the centralized regulation of medical practice, and the valorization of scientific empiricism—England was the scene of a remarkable upsurge in medical writing. Between the arrival of the Black Death in 1348 and the emergence of printed English books a century and a quarter later, thousands of discrete medical texts were copied, translated, and composed, largely for readers outside universities. These widely varied texts shared a model of a universe crisscrossed with physical forces and a picture of the human body as a changeable, composite thing, tuned materially to the world's vicissitudes. According to Julie Orlemanski, when writers like Geoffrey Chaucer, Robert Henryson, Thomas Hoccleve, and Margery Kempe drew on the discourse of phisik—the language of humors and complexions, leprous pustules and love sickness, regimen and pharmacopeia—they did so to chart new circuits of legibility between physiology and personhood. Orlemanski explores the texts of her vernacular writers to show how they deployed the rich terminology of embodiment and its ailments to portray symptomatic figures who struggled to control both their bodies and the interpretations that gave their bodies meaning. As medical paradigms mingled with penitential, miraculous, and socially symbolic systems, these texts demanded that a growing number of readers negotiate the conflicting claims of material causation, intentional action, and divine power. Examining both the medical writings of late medieval England and the narrative and poetic works that responded to them, Symptomatic Subjects illuminates the period's conflicts over who had the authority to construe bodily signs and what embodiment could be made to mean.

The Symptom and the Subject takes an in-depth look at how the physical body first emerged in the West as both an object of knowledge and a mysterious part of the self. Beginning with Homer, moving through classical-era medical treatises, and closing with studies of early ethical philosophy and Euripidean tragedy, this book rewrites the traditional story of the rise of body-soul dualism in ancient Greece. Brooke Holmes demonstrates that as the body (sôma) became a subject of physical inquiry, it decisively changed ancient Greek ideas about the meaning of suffering, the soul, and human nature. By undertaking a new examination of biological and medical evidence from the sixth through fourth centuries BCE, Holmes argues that it was in large part through changing interpretations of symptoms that people began to perceive the physical body with the senses and the mind. Once attributed primarily to social agents like gods and daemons, symptoms began to be explained by physicians in terms of the physical substances hidden inside the person. Imagining a daemonic space inside the person but largely below the threshold of feeling, these physicians helped to radically transform what it meant for human beings to be vulnerable, and ushered in a new ethics centered on the responsibility of taking care of the self. The Symptom and the Subject highlights with fresh importance how classical Greek discoveries made possible new and deeply influential ways of thinking about the human subject.

First published in 1990, this indispensable volume brings together authoritative, up-to-date, critical accounts of the present status of positron emission tomography (PET) in the study of movement disorders both in terms of the basic science relevant to PET and the clinical science related to the study of specific disease processes. For better understanding, it includes a review of the basic principles of PET and tracer kinetics. It also reviews clinical studies concerning Parkinson's and Huntington's disease, as well as some of the less common movement disorders such as progressive supranuclear palsy, olivopontocerebellar atrophy, and dystonia. Throughout the text, it emphasizes PET as a tool for the quantitative measurement of meaningful biochemical and physiological processes. This state-of-the-art work provides a perspective concerning the degree to which PET studies have advanced knowledge and the future role anticipated for PET. All clinical and basic researchers interested in functional imaging with PET and movement disorders will find this book an absolute must.

This book contains the contributions to the 30th Hemophilia Symposium, 1999. The main topics are HIV infection, inhibitors in hemophilia, modern treatment of hemophilia, drug-induced thrombophilia and pediatric hemostasiology. The volume is rounded off by numerous free papers and posters on hemophilia and associated topics.