This volume presents a comprehensive overview of the latest developments in symbiosis research. It covers molecular, organellar, cellular, immunologic, genetic and evolutionary aspects of symbiotic interactions in humans and other model systems. The book also highlights new approaches to interdisciplinary research and therapeutic applications. Symbiosis refers to any mutually beneficial interaction between different organisms. The symbiotic origin of cellular organelles and the exchange of genetic material between hosts and their bacterial and viral symbionts have helped shaped the current diversity of life. Recently, symbiosis has gained a new level of recognition, due to the realization that all organisms function as a holobiome and that any kind of interference with the hosts influences their symbionts and vice versa, and can have profound consequences for the survival of both. For example, in humans, the microbiome, i.e., the entirety of all the microorganisms living in association with the intestines, oral cavity, urogenital system and skin, is partially inherited during pregnancy and influences the maturation and functioning of the human immune system, protects against pathogens and regulates metabolism. Symbionts also regulate cancer development, wound healing, tissue regeneration and stem cell function. The medical applications of this new realization are vast and largely uncharted. The composition and robustness of human symbionts could make them a valuable diagnostic tool for predicting impending diseases, and the manipulation of symbionts could yield new strategies for the treatment of incurable diseases.

Cognition-Based Evolution is the first comprehensive alternative to 20th-century Neodarwinism, proposing a radical 21st-century evolutionary framework with a novel point of origination: all cells are intelligent and must measure uncertain environmental information to sustain themselves. In Cognition-Based Evolution, life is defined by cognition. From this differential stance, evolutionary biology transforms into the science of why, how, what, and with whom cells measure and communicate under stressful environmental conditions. Life's context is uncertain environmental information, communication is its means, and genes are its tools. Evolution is its yield as continuous non-random self-referential cellular problem-solving.

In the mid- to late-twentieth century, large scientific conflicts flared in two seemingly distinct fields of scientific inquiry. In bioenergetics, which examines how organisms obtain and utilize energy, the chemiosmotic hypothesis of Mitchell suggested a novel mechanism for energy conversion. In evolutionary biology, meanwhile, Wynne Edwards strongly articulated the view that organisms may act for the “good of the group.” This work crystalized a long history of imprecise thinking about the evolution of cooperation. While both controversies have received ample attention, no one has ever suggested that one might inform the other, i.e., that energy metabolism in general and chemiosmosis in particular might be relevant to the evolution of cooperation. The central idea is nevertheless remarkably simple. Chemiosmosis rapidly converts energy, and once storage capacity is exceeded, an overabundance of product has various negative consequences. While to some extent chemiosmotic processes can be modulated, under certain circumstances it is also possible to simply disperse the products into the environment. This book argues that these two heretofore distinct scientific disciplines are connected, thereby suggesting that a ubiquitous process of energy conversion may underlie the evolution of cooperation and link major transitions in the history of life that have been regarded as mechanistically unrelated.

Why evolution is like a network, not a family tree—and why it matters for understanding the health of all living things In The Network of Life, David Mindell explains why the conventional narrative of evolution needs to evolve. Ever since Darwin, evolution has largely been thought to work like a family tree in which species are related through a series of branching events. But, today, a growing knowledge of the ways species share genetic materials in a process known as horizontal evolution has revealed that evolution is actually a network of shared genealogy in which species are more interconnected than previously thought. In this book, Mindell presents this new narrative of life’s evolution and its profound implications for all life on Earth. The Network of Life describes the drivers of horizontal evolution—interbreeding and genetic recombination, the merger of species, horizontal gene transfer, and coevolution. The network view of evolution that emerges supports a new symbiotic theory of health, which holds that the future health of humans, other species, and our shared environments depends on evolution and adaptation across life’s network. Difficult times lie ahead for many of Earth’s species as climates and habitats transform. At the same time, new and altered life-forms are arising and spreading in association with human activities. We are also learning to reshape and create life by mimicking the mechanisms of horizontal evolution, and we are coevolving with technology as we enhance our bodies, brains, and life spans. The Network of Life shows why and how increasing our knowledge of horizontal evolution can provide critical lessons as we navigate our looming challenges.

We are in the midst of a revolution. It is a scientific revolution built upon the tools of molecular biology, with which we probe and prod the living world in ways unimaginable a few decades ago. Need to track a bacterium at the root of a hospital outbreak? No problem: the offending germ's complete genetic profile can be obtained in 24 hours. We insert human DNA into E. coli bacteria to produce our insulin. It is natural to look at biotechnology in the 21st century with a mix of wonder and fear. But biotechnology is not as 'unnatural' as one might think. All living organisms use the same molecular processes to replicate their genetic material and the same basic code to 'read' their genes. The similarities can be seen in their DNA. Here, John Archibald shows how evolution has been 'plugging-and-playing' with the subcellular components of life from the very beginning and continues to do so today. For evidence, we need look no further than the inner workings of our own cells. Molecular biology has allowed us to gaze back more than three billion years, revealing the microbial mergers and acquisitions that underpin the development of complex life. One Plus One Equals One tells the story of how we have come to this realization and its implications.