Survival, the IISS’s bimonthly journal, challenges conventional wisdom and brings fresh, often controversial, perspectives on strategic issues of the moment. In this issue: Franz-Stefan Gady and Michael Kofman highlight the pitfalls of grafting a Western manoeuvre-oriented approach to war onto the Russia–Ukraine conflict Irene Mia examines the chasm between Javier Milei’s dramatic rhetoric and the domestic and international obstacles he faces to changing Argentina’s foreign and economic policies Edoardo Campanella and John Haigh outline the necessity of meaningful dialogue between the West and China to prevent the internet’s fragmentation John Raine assesses the geopolitical trends that the Gaza war has set in motion and the issues they create for Ukraine’s defence against Russia And seven more thought-provoking pieces, as well as our regular Book Reviews and Noteworthy column. Editor: Dr Dana Allin Managing Editor: Jonathan Stevenson Associate Editor: Carolyn West Editorial Assistant: Conor Hodges

Owing to the availability of more advanced genetically engineered pigs, more immunological and physiological barriers have been overcome. With the results of pig organ xenotransplantation steadily improving, consideration is now given to the first clinical trials of xenotransplantation. The first step is kidneys, but possibilities also exist in pig islet transplantation for patients with diabetes.

Published each year since 1959, The Military Balance is an indispensable reference to the capabilities of armed forces across the globe. It is used by academia, the media, armed forces, the private sector and government. It is an open-source assessment of the military forces and equipment inventories of 171 countries, with accompanying defence economics and procurement data. Alongside detailed country data, The Military Balance assesses important defence issues, by region, as well as key global trends, such as in defence technology and equipment modernisation. This analysis is accompanied by full-colour graphics, including maps and illustrations. With extensive explanatory notes and reference information, The Military Balance is as straightforward to use as it is extensive. The 2022 edition is accompanied by a fullcolour wall chart illustrating security dynamics in the Arctic.

Hospital-acquired infections are common and often result in life-threatening complications, mostly facing critically ill patients in the intensive care unit. Patients with hospital-acquired infections may die from bacteremia/fungal/viral infection or hyperinflammatory complications because of an uncontrolled over-activation of the innate immune system with pathological levels of circulating proinflammatory cytokines, or from multiorgan failure. In addition to eliciting a robust inflammatory response, it paradoxically renders the host in an immunocompromised state at the late stage of the disease progression. Severe infectious diseases, including sepsis and septic shock are among the most common reasons for death in hospitals. Sepsis is an infection-induced syndrome characterized by a generalized inflammatory state and represents a frequent complication in surgical patients and in immunocompromised patients. Sepsis is a common, expensive, and frequently associated with a fatal outcome. Every 3 to 4 seconds somebody dies with sepsis, and it is one of the leading causes of death worldwide.

Gliomas are neoplasms originating in glial cells, the most malignant and frequent primary tumors of the Central Nervous System (CNS), representing approximately 40-50% of all intracranial tumors. Following the World Health Organization (WHO) guidelines, gliomas are classified into grades I-IV, regarding their malignancy degree. The latest report from WHO on CNS tumors considers that glioblastoma (GB), a grade IV adult-type diffuse glioma comprising isocitrate dehydrogenase (IDH)-wildtype tumors. Despite all efforts to improve patient survival and quality of life, the median survival remains lower due to the lack of effective diagnostic tools, poor prognosis, and limited therapeutic options. Regarding this, the design of novel treatment strategies is of the utmost importance. This can be by either the discovery of new medicines (for example synthetic compounds), repurposing known drugs or exploring novel strategies of drug delivery by nanotechnological platforms to improve treatment response and long-term survival of patients. Inter and intra-tumor heterogeneity mainly contribute to the poor prognosis and treatment efficacy. Therefore, exploiting tumor microenvironment (TME) and understanding GB’s cellular and molecular aspects are fundamental to developing more effective and better-tolerated personalized therapies. Thus, addressing physiological mechanisms involved in cancer development, progression and recurrence is crucial. Concerning this, our goal with this research topic is to share the latest advances in tumor-specific therapies for gliomas, especially GB, as well as to provide experimental validation of new bioactive molecules and their antitumor mechanism of action. Authors are invited to submit original research, review articles and systematic reviews covering, but not restricted to, the following topics: 1) Novel targeted therapies; 2) Mechanism of action and affected signaling pathways; 3) Repurposing drugs; 5) New chemical entities; 6) Pharmaceutical nanotechnology; 7) Drug delivery systems; 8) Preclinical and clinical studies of therapeutic molecules; 9) Potential molecular biomarkers to targeted therapies using proteomics or transcriptomics.

God Wants You Prepared for These Perilous Times! The Holy Spirit warned that perilous times would come in the very last of the last days. Were in that time frame right now, and it is imperative that we know how to survive victoriously. Scripture prophesies that spiritual tempests will spread across the world with far-reaching consequences. But we do not have to be a casualty of these storms! In this eye-opening survival guide, Rick Renner covers prophetic scriptures about the end times and how to prepare for them. He teaches: What the word perilous really means and why God is alerting you. What exact characteristics will mark society in the very last days. What actions to take to protect yourself and those you love. Strategies to stop the devil from attacking you and your loved ones. If youre concerned about what you are witnessing in society and even in the Church the answers you need to maintain your victory are in this book! Its a survival guide for thriving in these perilous last days.

The perfect home-reference book for both seasoned outdoorsmen and average citizens to learn comprehensive outdoor survival techniques. This practical survival guide from U.S. Special Forces Captain and outdoor survival expert Mykel Hawke includes illustrated instruction on: shelter and water food and fire tools and medicine navigation and signaling survival psychology Hawke's engaging style and matter-of-fact attitude-not to mention his incredible resume in the survival arena-elevates this book above its competition.