My dissertation aims to inform strategies for the estimation of prevalence and burden of disease caused by neglected intestinal parasitic infections in the United States, with a view toward their control. The current burden of soil-transmitted helminth (STH) and intestinal protozoa (IP) infections in the US is unknown; consequentially, little existing surveillance and disease control framework exists to protect US residents. This group of infections is considered neglected due to lack of adequate surveillance. For example, despite documented historical and contemporary autochthonous transmission, the STH are not required by state law to be reported nor are they nationally notifiable, with the exception of mandated reporting for three species in Texas, as of September 2015. Without a tangible sense of the disease burden, little attention is paid to the prevention, diagnosis, and/or treatment of STH and IP in the US. I investigate the hypothesis that a significant burden of neglected intestinal parasitic infections persists in vulnerable communities throughout the US, and seek to identify and characterize the prevalence of intestinal parasites in a study at the local level. Our results from an epidemiological study in central Texas, as well as a species distribution modeling study of the STH Strongyloides stercoralis, suggest that STH represent a sufficient threat to US public health and therefore merit an organized public health response. Given that the US has a rudimentary or non-existent framework for addressing STH, I conduct a systematic review of global examples of intestinal parasite prevalence estimation, surveillance, and control programs to model solutions that can be adapted for the US context. My dissertation contributes to the characterization of a neglected public health problem, quantifying the burden of intestinal parasites locally and offering evidence-based solutions at the local, state, national, and health systems levels. The epidemiological insights we have gained about intestinal parasitic infections in the US suggest several public health, clinical, and policy strategies that may help to address the burden of disease, and, combined with additional historic and contemporary evidence call for a shift in the way we think about health equity and the provision of human rights in the US

Examines the economic underworld of migrant farm workers, the aged, minority groups, and other economically underprivileged groups.

In Poverty and Neglected Tropical Diseases in the American Rural South, Christine Crudo Blackburn and Macey T. Lively study regions of the United States rarely acknowledged by the average American. These are regions of extreme poverty in the rural American South where a mixture of historical discrimination, structural discrimination, lack of opportunities, and decaying infrastructure conspire to create an environment conducive to chronic, debilitating diseases known as Neglected Tropical Diseases (NTDs). Blackburn and Lively explore the conditions that allow NTDs to thrive in a wealthy nation like the United States when such diseases are typically associated with the poorest communities in Africa, Asia, and South America. Poverty and Neglected Tropical Diseases pulls back the curtain on the reality of poverty and disease in America and tell the story of failing sanitation infrastructure, the lack of clean water, the inability to access healthcare, and the lack of financial security through the eyes of those living it every day.

Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

Forgotten People, Forgotten Diseases Second Edition The neglected tropical diseases (NTDs) are the most common infections of the world's poor, but few people know about these diseases and why they are so important. This second edition of Forgotten People, Forgotten Diseases provides an overview of the NTDs and how they devastate the poor, essentially trapping them in a vicious cycle of extreme poverty by preventing them from working or attaining their full intellectual and cognitive development. Author Peter J. Hotez highlights a new opportunity to control and perhaps eliminate these ancient scourges, through alliances between nongovernmental development organizations and private-public partnerships to create a successful environment for mass drug administration and product development activities. Forgotten People, Forgotten Diseases also Addresses the myriad changes that have occurred in the field since the previous edition. Describes how NTDs have affected impoverished populations for centuries, changing world history. Considers the future impact of alliances between nongovernmental development organizations and private-public partnerships. Forgotten People, Forgotten Diseases is an essential resource for anyone seeking a roadmap to coordinate global advocacy and mobilization of resources to combat NTDs.

"The presence, or absence, of neglected tropical diseases (NTDs) can be seen as a proxy for poverty and for the success of interventions aimed at reducing poverty. Today, coverage of the public-health interventions recommended by the World Health Organization (WHO) against NTDs may be interpreted as a proxy for universal health coverage and shared prosperity - in short, a proxy for coverage against neglect. As the world's focus shifts from development to sustainable development, from poverty eradication to shared prosperity, and from disease-specific goals to universal health coverage, control of NTDs will assume an important role towards the target of achieving universal health coverage, including individual financial risk protection. Success in overcoming NTDs is a "litmus test" for universal health coverage against NTDs in endemic countries. The first WHO report on NTDs (2010) set the scene by presenting the evidence for how these interventions had produced results. The second report (2013) assessed the progress made in deploying them and detailed the obstacles to their implementation. This third report analyses for the first time the investments needed to achieve the scale up of implementation required to achieve the targets of the WHO Roadmap on NTDs and universal coverage against NTDs. INVESTING TO OVERCOME THE GLOBAL IMPACT OF NEGLECTED TROPICAL DISEASES presents an investment strategy for NTDs and analyses the specific investment case for prevention, control, elimination and eradication of 12 of the 17 NTDs. Such an analysis is justified following the adoption by the Sixty-sixth World Health Assembly in 2013 of resolution WHA6612 on neglected tropical diseases, which called for sufficient and predictable funding to achieve the Roadmap's targets and sustain control efforts. The report cautions, however, that it is wise investment and not investment alone that will yield success. The report registers progress and challenges and signals those that lie ahead. Climate change is expected to increase the spread of several vector-borne NTDs, notably dengue, transmission of which is directly influenced by temperature, rainfall, relative humidity and climate variability primarily through their effects on the vector. Investments in vector-borne diseases will avoid the potentially catastrophic expenditures associated with their control. The presence of NTDs will thereby signal an early warning system for climate-sensitive diseases. The ultimate goal is to deliver enhanced and equitable interventions to the most marginalized populations in the context of a changing public-health and investment landscape to ensure that all peoples affected by NTDs have an opportunity to lead healthier and wealthier lives."--Publisher's description.

Why do diseases of poverty afflict more people in wealthy countries than in the developing world? In 2011, Dr. Peter J. Hotez relocated to Houston to launch Baylor’s National School of Tropical Medicine. He was shocked to discover that a number of neglected diseases often associated with developing countries were widespread in impoverished Texas communities. Despite the United States’ economic prowess and first-world status, an estimated 12 million Americans living at the poverty level currently suffer from at least one neglected tropical disease, or NTD. Hotez concluded that the world’s neglected diseases—which include tuberculosis, hookworm infection, lymphatic filariasis, Chagas disease, and leishmaniasis—are born first and foremost of extreme poverty. In this book, Hotez describes a new global paradigm known as “blue marble health,” through which he asserts that poor people living in wealthy countries account for most of the world’s poverty-related illness. He explores the current state of neglected diseases in such disparate countries as Mexico, South Korea, Argentina, Australia, the United States, Japan, and Nigeria. By crafting public policy and relying on global partnerships to control or eliminate some of the world’s worst poverty-related illnesses, Hotez believes, it is possible to eliminate life-threatening disease while at the same time creating unprecedented opportunities for science and diplomacy. Clear, compassionate, and timely, Blue Marble Health is a must-read for leaders in global health, tropical medicine, and international development, along with anyone committed to helping the millions of people who are caught in the desperate cycle of poverty and disease.