Surrogate Tissue Analysis
Title | Surrogate Tissue Analysis PDF eBook |
Author | Michael E. Burczynski |
Publisher | CRC Press |
Pages | 329 |
Release | 2005-11-10 |
Genre | Medical |
ISBN | 1420038095 |
Both an introduction and a fundamental reference, this book explores how to apply genomic, proteomic, and metabolomic technologies to surrogate tissue analysis. It reviews fundamental analytical issues and actual initial results generated using these technologies. The book covers transcriptional profiling (genomics), protein profiling (proteomics), methylation profiling (epigenomics), metabolite profiling (metabolomics) and additional biomarker identification methods that can be applied to surrogate tissues. This book is useful to researchers and scientists interested in applying novel methodologies for identifying biomarkers in the fields of pharmacology, toxicology, and medicine.
Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease
Title | Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease PDF eBook |
Author | Institute of Medicine |
Publisher | National Academies Press |
Pages | 335 |
Release | 2010-06-25 |
Genre | Medical |
ISBN | 0309157277 |
Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process.
Clinical Labor
Title | Clinical Labor PDF eBook |
Author | Melinda Cooper |
Publisher | Duke University Press |
Pages | 290 |
Release | 2014-01-22 |
Genre | Social Science |
ISBN | 0822377004 |
Forms of embodied labor, such as surrogacy and participation in clinical trials, are central to biomedical innovation, but they are rarely considered as labor. Melinda Cooper and Catherine Waldby take on that project, analyzing what they call "clinical labor," and asking what such an analysis might indicate about the organization of the bioeconomy and the broader organization of labor and value today. At the same time, they reflect on the challenges that clinical labor might pose to some of the founding assumptions of classical, Marxist, and post-Fordist theories of labor. Cooper and Waldby examine the rapidly expanding transnational labor markets surrounding assisted reproduction and experimental drug trials. As they discuss, the pharmaceutical industry demands ever greater numbers of trial subjects to meet its innovation imperatives. The assisted reproductive market grows as more and more households look to third-party providers for fertility services and sectors of the biomedical industry seek reproductive tissues rich in stem cells. Cooper and Waldby trace the historical conditions, political economy, and contemporary trajectory of clinical labor. Ultimately, they reveal clinical labor to be emblematic of labor in twenty-first-century neoliberal economies.
Biomarkers for Traumatic Brain Injury
Title | Biomarkers for Traumatic Brain Injury PDF eBook |
Author | Svetlana Dambinova |
Publisher | Royal Society of Chemistry |
Pages | 247 |
Release | 2012 |
Genre | Medical |
ISBN | 1849733899 |
Due to injuries sustained in sports and in combat, interest in traumatic brain injury (TBI) has never been greater. This book will fulfill a gap in understanding of what is occurring in the brain following injury that can subsequently be detected in biological fluids and imaging.
The Evaluation of Surrogate Endpoints
Title | The Evaluation of Surrogate Endpoints PDF eBook |
Author | Geert Molenberghs |
Publisher | Springer Science & Business Media |
Pages | 440 |
Release | 2005-02-28 |
Genre | Mathematics |
ISBN | 9780387202778 |
Covers the latest research on a sensitive and controversial topic in a professional and well researched manner. Provides practical outlook as well as model guidelines and software tools that should be of interest to people who use the software tools described and those who do not. Related title by Co-author Geert Molenbergh has sold more than 3500 copies world wide. Provides dual viewpoints: from scientists in the industry as well as regulatory authorities.
Monitoring Human Tissues for Toxic Substances
Title | Monitoring Human Tissues for Toxic Substances PDF eBook |
Author | National Research Council |
Publisher | National Academies Press |
Pages | 224 |
Release | 1991-02-01 |
Genre | Science |
ISBN | 0309044375 |
The National Human Monitoring Program (NHMP) identifies concentrations of specific chemicals in human tissues, including toxicologic testing and risk assessment determinations. This volume evaluates the current activities of the NHMP; identifies important scientific, technical, and programmatic issues; and makes recommendations regarding the design of the program and use of its products.
Gene Expression Profiling in Surrogate Tissues to Identify Biomarkers Following Conazole Exposure
Title | Gene Expression Profiling in Surrogate Tissues to Identify Biomarkers Following Conazole Exposure PDF eBook |
Author | |
Publisher | |
Pages | |
Release | 2004 |
Genre | |
ISBN |
Conazoles are a class of azole fungicides which are used for agricultural and pharmaceutical applications. This study examined two conazoles that possess a range of reproductive, carcinogenic, and neurodevelopmental effects. Sprague-Dawley rats were dosed daily by oral gavage for 14 days with triadimefon (5 or 115 mg/kg/day) or myclobutanil (10 or 150 mg/kg/day). Relative liver weight increased following high dose triadimefon and myclobutanil exposure. Weight changes were not observed in testes, nor were there significant changes in serum testosterone levels. Microarray analysis of 4,370 genes yielded forty-eight differentially expressed genes in blood. Of these, nine genes were found to be concordant with liver and testis gene expression data.