From the notorious Lizzie Borden to the innumerable, haunted rooms of Sarah Winchester's mysterious mansion this offbeat, insightful, first-ever book of its kind explores the history behind America’s female ghosts, the stereotypes, myths, and paranormal tales that swirl around them, what their stories reveal about us—and why they haunt us . . . Sorrowful widows, vengeful jezebels, innocent maidens, wronged lovers, former slaves, even the occasional axe-murderess—America’s female ghosts differ widely in background, class, and circumstance. Yet one thing unites them: their ability to instill fascination and fear, long after their deaths. Here are the full stories behind some of the best-known among them, as well as the lesser-known—though no less powerful . . . Tales whispered in darkness often divulge more about the teller than the subject. America’s most famous female ghosts, from ‘Mrs. Spencer’ who haunted Joan Rivers’ New York apartment to Bridget Bishop, the first person executed during the Salem witchcraft trials, mirror each era’s fears and prejudices. Yet through urban legends and campfire stories, even ghosts like the nameless hard-working women lost in the infamous Triangle Shirtwaist Factory fire —achieve a measure of power and agency in death, in ways unavailable to them as living women. Riveting for skeptics and believers alike, with humor, curiosity, and expertise, A Haunted History of Invisible Women offers a unique lens on the significant role these ghostly legends play both within the spook-seeking corners of our minds and in the consciousness of a nation. Afterword by Bram Stoker Award-winning author Linda D. Addison “An absolute must-buy for the spooky people of the world . . . utterly brilliant.” —Mallory O'Meara, bestselling author of The Lady from the Black Lagoon and Girly Drinks “If this book doesn’t leave with you a sense of wonder and a healthy dose of goosebumps, check your pulse—you may already be among the spirits.” --Marc Hartzman, author of Chasing Ghosts: A Tour of Our Fascination with Spirits and the Supernatural

Today's moviegoers and critics generally consider some Hollywood products--even some blockbusters--to be legitimate works of art. But during the first half century of motion pictures very few Americans would have thought to call an American movie "art." Up through the 1950s, American movies were regarded as a form of popular, even lower-class, entertainment. By the 1960s and 1970s, however, viewers were regularly judging Hollywood films by artistic criteria previously applied only to high art forms. In Hollywood Highbrow, Shyon Baumann for the first time tells how social and cultural forces radically changed the public's perceptions of American movies just as those forces were radically changing the movies themselves. The development in the United States of an appreciation of film as an art was, Baumann shows, the product of large changes in Hollywood and American society as a whole. With the postwar rise of television, American movie audiences shrank dramatically and Hollywood responded by appealing to richer and more educated viewers. Around the same time, European ideas about the director as artist, an easing of censorship, and the development of art-house cinemas, film festivals, and the academic field of film studies encouraged the idea that some American movies--and not just European ones--deserved to be considered art.

Allosteric Modulation of G Protein-Coupled Receptors reviews fundamental information on G protein-coupled receptors (GPCRs) and allosteric modulation, presenting original research in the area and collectively providing a comprehensive description of key issues in GPCR allosteric modulation. The book provides background on core concepts of molecular pharmacology while also introducing the most important advances and studies in the area. It also discusses key methodologies. This is an essential book for researchers and advanced students engaged in pharmacology, toxicology and pharmaceutical sciences training and research. Many of the GPCR-targeted drugs released in the past decade have specifically worked via allosteric mechanisms. Unlike direct orthosteric-acting compounds that occupy a similar receptor site to that of endogenous ligands, allosteric modulators alter GPCR-dependent signaling at a site apart from the endogenous ligand. Recent methodological and analytical advances have greatly improved our ability to understand the signaling mechanisms of GPCRs. We now know that allostery is a common regulatory mechanism for all GPCRs and not – as we once believed – unique to a few receptor subfamilies. - Introduces background on core concepts of molecular pharmacology, including statistical analyses, non-linear regression, complex models and GPCR-dependent signal transduction as they relate to allosteric modulation - Discusses critical advances and landmark studies, including discoveries in the area of GPCR allosteric modulation, which are reviewed for their importance in positive and negative regulation, protein-protein interactions, and small molecule drug discovery - Includes key methodologies used to study allosteric modulation at the in silico, in vitro, and in vivo levels of drug discovery and characterization

It charts the course of the emerging discipline of integrative molecular biology from macromolecular sequences to a biological (and theoretical) perspective, showing that novel integrative methodologies and paradigms are emerging at the confluence of such disciplines as computer science, logic, linguistics, and mathematics.