First Published in 1981, this book is an in-depth exploration into the sulfation process in the manufacturing of pharmaceuticals. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for Students of Pharmacology, and other practitioners in their respective fields.

Environmental toxicology is generally held to be the study of the potential of constituents of outdoor environments to impact either human health or the biological structure of the ecosystems involved. This volume is a first attempt to integrate toxicological studies of all of the many human environments, both indoor and outdoor, and their complex interrelationships. Included are considerations of natural environments, the agroecosystem, occupational, urban and domestic environments as well as the environment associated with Superfund sites and military deployments. The primary emphasis is on public health, including the potential health effects of toxicants found in different environments, the bioprocessing of such toxicants in humans and surrogate animals and the principles of risk analysis. Approaches the toxicology of human environments in a new and unique way, stressing the complex interrelationships of all human environments and the implication for human and environmental health Each chapter is written by an acknowledged expert and is addressed to those interested in the broader implications of the environmental modifications that are always associated with the activities of humans living and working in them

The existence of multiple sulfotransferases (SULTS) was first discovered in 1958. Since then, any attempts to create a comprehensive text dedicated to sulfation and sulfotransferases have been rare and, thanks to rapid advances in molecular biology and biochemistry, quickly outdated. However, those advances have permitted an accelerated understanding of human sulfotransferase activity and with it the creation of a growing database on sulfotransferases that, until now, has remained scattered in the literature. Human Cytosolic Sulfotransferases serves an important function by the mere feat of culling the information from the literature to present an up-to-date summary of the field. Fortunately, the editors have gone a step further in providing us with a multidisciplinary overview of human sulfotransferases, covering not only basic biochemistry, genetics, and molecular biology, but also exploring current clinical uses involving pharmacology, enzymology, and environmental toxicology. The book's thirteen chapters, written by some of the most renowned scientists in the field, address the huge diversity of topics that are impacted by sulfation. Included are discussions that move from general nomenclature and structure to molecular cloning of human cytosolic sulfotransferases, and sulfate conjugation in pharmocogenetics and pharmacogenomics. Entire chapters focus on sulfotransferases in the human fetus and neonate, sulfation of thyroid hormones, as well as estrogen sulfotransferases in breast cancer and the activation/inactivation of carcinogens and mutagens by human sulfotransferases.

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. - Provides information on cancer research - Outstanding and original reviews - Suitable for researchers and students

Structure and reactivity of phenolic compounds. Isolation and identification of phenolic compounds in biological materials. The natural distribution of the phenolic aglycones. Phenolic glycosides and their natural distribution. The genetics of phenolic compounds. Metabolism of phenolics in animals. Metabolism of phenolics in higher plants and micro-organisms. Major pathways of biosynthesis of phenols. Lignin and tannin biosynthesis. Enzymology of phenolic biosynthesis. Physiological studies on phenolic biosynthesis. The physiology and pharmacology of phenolic compounds in animals. Pathological function of phenolic compounds in plants. Relations between the taste and structure of some phenolic glycosides.

Molecular Toxicology is the first volume of a three-volume set Molecular, Clinical and Environmental Toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals in daily life. By providing intriguing insights far down to the molecular level, this work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health and engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.