Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. - Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field - The essential resource for anyone involved in the study of bones and bone diseases - Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics - Readers can easily search and locate information quickly as it will be online with this new edition

Bioregulators of Reproduction focuses on the biological regulators of reproductive processes. Discussions are grouped based on sex differentiation and determination, germ cell reproduction, gonadotropins, nonsteroidal gonadal hormones, in vitro fertilization, and post-fertilization. This text is organized into six sections and comprised of 31 chapters, beginning with a discussion on the most important regulatory mechanisms underlying reproduction. The reader is then methodically introduced to the role of the H-Y antigen in primary sex determination, H-Y antigenic determinants of human testis-organizing protein, and how H-Y antibodies confuse antigenic complexes with unaltered self or allo-MHC antigens. The cellular mechanisms of sexual differentiation of the brain, meiosis in female mammals, and interspecies comparisons in molecular reproductive biology are also considered. Other chapters explore the role of haplodins in the ovarian and extraovarian control of meiosis; the link between nucleoprotein transitions and chromatin changes during rat spermatogenesis; and gonadotropin secretion in primates. This book will be of interest to students and scientists in fields ranging from biology and neuroendocrinology to genetics, biochemistry, biophysics, pathology, and zoology.

Cell Biology of the Major Histocompatibility Complex documents the proceedings of a symposium on ""Cell Biology of the Major Histocompatibility Complex"" held at Arden House on the Harriman Campus of Columbia University from June 8 -10, 1984. The meeting was the ninth of the P & S Biomedical Sciences Symposia. The book is organized into five parts. Part I on the structure of MHC molecules includes papers on human histocompatibility antigens; the cloning of human MHC; and organization of the genes of the H-2 complex. Part II on alternate forms of MHC molecules includes studies on the expression of a secreted form of the MHC class I antigen and alternative splicing in the H-2 multigene family. Part III deals with MHC biosynthesis, intracellular transport, and membrane expression. It includes studies on the manipulation of glycans on antigens of the MHC and dynamics of MHC molecules in lymphoid cells. Part IV on homologues of class I MHC molecules covers topics such as Tla expression in normal and malignant cells and the Qa series of antigens. Part V on the association of MHC with antigens includes studies such as histocompatibility molecules as immune response gene products and molecular nature of T-cell recognition of antigen.

Significant recent advances in cell culture technology now permit a detailed biochemical and molecular analysis of differentiation in both normal and tumor cells. These studies are important in attempting to understand the complex factors involved in normal growth and development, as well as the abnormalities associated with carcinogenesis. Mechanisms of Differentiation, Volumes I and II, is comprised of review chapters addressing various topics of current interest in this important area of research. Topics discussed include genes controlling differentiation, changes in gene expression during differentiation, induction of differentiation, induction of differentiation as a mode of action of chemotherapeutic agents, and the effect of cell shape, growth factors and differentiation modulating agents on the differentiated cell phenotype. Mechanisms of Differentiation is valuable to researchers involved in differentiation and development, carcinogenesis, cell biology, chemotherapy, and immunology.

Regulatory T Lymphocytes documents the proceedings of a symposium on ""Regulatory T Lymphocytes"" held at Arden House on the Harriman Campus of Columbia University from June 8-10, 1979. The meeting was the fourth of the P&S Biomedical Sciences Symposia. Starting with the opening address on regulatory T lymphocytes and their antigen receptors, the remainder of the book presents the contributions made by researchers at the symposium. These contributions are organized into seven parts. Part I contains studies T cell receptors. Part II presents studies on T cell subpopulations. Parts III and IV examine helper T cells. Parts V and VI deal with suppressor T cells. Part VII contains papers on regulatory T cell circuits.

First multi-year cumulation covers six years: 1965-70.