Engl.

Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided. Features: Highlights emerging scientific fields relevant to drug discovery such as the microbiome, nanotechnology, and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded libraries Case study detailing the discovery of the anti-cancer drug, lorlatinib Venture capitalist commentary on trends and best practices in drug discovery and development Comprehensive review of regulations and their impact on drug development, highlighting special populations, orphan drugs, and pharmaceutical compounding Multidiscipline functioning of an Academic Research Enterprise, plus a chapter on Ethical Concerns in Research Contributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business

Human Structure is an innovative introduction to human gross anatomy with a twofold approach to view the basics of anatomy from a broad scientific perspective and to explain the facts of form and function in terms and concepts that minimize the usual confusion and anxiety of beginning anatomy studies. Functional, comparative, and developmental anatomy are ingeniously woven into a single explanatory perspective, presenting human anatomy as an intelligible whole rather than as a heap of disconnected facts to be memorized. As a result, Human Structure is suitable not only for first-year medical students but also for undergraduates in premedical or biological science courses, for students in paramedical or college-level nursing programs, and indeed for anyone seeking a refresher course in human anatomy. The book begins with the generalized segmental organization characteristic of vertebrates and then examines the most obviously segmented parts of the human body: the bones, muscles, vessels, and nerves of the trunk between the neck and the pelvis. The book progresses through regions where the simple organizational plan has undergone more and more radical modifications and ends with the ancient and extreme specializations found in the head. At each step, the authors widen our intellectual understanding of how these modifications have been imposed, onto-genetically or phylogenetically, upon simpler precursors. The prose is personal and literate, peppered with inventive elucidations of concepts and accompanied by a wealth of illustrations designed for conceptual clarity and ease of visualization. The level of presentation has been finely tuned, over several years of class testing, to enhance its pedagogical effectiveness in human anatomy courses.

Teaching Anatomy: A Practical Guide is the first book designed to provide highly practical advice to both novice and experienced gross anatomy teachers. The volume provides a theoretical foundation of adult learning and basic anatomy education and includes chapters focusing on specific issues that teachers commonly encounter in the diverse and challenging scenarios in which they teach. The book is designed to allow teachers to adopt a student-centered approach and to be able to give their students an effective and efficient overall learning experience. Teachers of gross anatomy and other basic sciences in undergraduate healthcare programs will find in this unique volume invaluable information presented in a problem-oriented, succinct, and user-friendly format. Developed by renowned, expert authors, the chapters are written concisely and in simple language, and a wealth of text boxes are provided to bring out key points, to stimulate reflection on the reader’s own situation, and to provide additional practical tips. Educational theories are selectively included to explain the theoretical foundation underlying practical suggestions, so that teachers can appropriately modify the strategies described in the book to fit their own educational environments. Comprehensive and a significant contribution to the literature, Teaching Anatomy: A Practical Guide is an indispensable resource for all instructors in gross anatomy.