Structures, Signaling Mechanisms, and Functions of Types I and III Interferons
Title | Structures, Signaling Mechanisms, and Functions of Types I and III Interferons PDF eBook |
Author | Ronald L. Rabin |
Publisher | Frontiers Media SA |
Pages | 133 |
Release | 2021-04-23 |
Genre | Medical |
ISBN | 2889666808 |
Dr. Walter receives financial support from Pfizer. The other Topic Editor declares no competing interest with regards to the Research Topic theme.
Interleukin-10 in Health and Disease
Title | Interleukin-10 in Health and Disease PDF eBook |
Author | Simon Fillatreau |
Publisher | Springer |
Pages | 244 |
Release | 2014-07-08 |
Genre | Medical |
ISBN | 366243492X |
This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date.
Viral Gastroenteritis
Title | Viral Gastroenteritis PDF eBook |
Author | Shunzo Chiba |
Publisher | Springer Science & Business Media |
Pages | 301 |
Release | 2012-12-06 |
Genre | Medical |
ISBN | 3709165539 |
Recently, rapid developments have occurred in the field of viral gastroenteritis. This book is an update of fundamental and practical aspects of viral gastroenteritis. Among the various agents that cause viral gastroenteritis, group A rotaviruses and caliciviruses are the focus of this volume because of their clinical impact and the significance of new findings about them.
Viral Pathogenesis
Title | Viral Pathogenesis PDF eBook |
Author | Michael G. Katze |
Publisher | Academic Press |
Pages | 368 |
Release | 2015-12-30 |
Genre | Medical |
ISBN | 0128011742 |
Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology. - Covers all aspects of viral infection, including viral entry, replication, and release, as well as innate and adaptive immunity and viral pathogenesis - Provides a fresh perspective on the approaches used to understand how viruses cause disease - Features molecular profiling techniques, whole genome sequencing, and innovative computational methods - Highlights the use of contemporary approaches and the insights they provide to the field
Molecular Biology of the Cell
Title | Molecular Biology of the Cell PDF eBook |
Author | |
Publisher | |
Pages | 0 |
Release | 2002 |
Genre | Cells |
ISBN | 9780815332183 |
Signaling Mechanisms Regulating T Cell Diversity and Function
Title | Signaling Mechanisms Regulating T Cell Diversity and Function PDF eBook |
Author | Jonathan Soboloff |
Publisher | CRC Press |
Pages | 258 |
Release | 2017-03-27 |
Genre | Medical |
ISBN | 149870509X |
T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Protein Kinase-mediated Decisions Between Life and Death
Title | Protein Kinase-mediated Decisions Between Life and Death PDF eBook |
Author | Ayse Basak Engin |
Publisher | Springer Nature |
Pages | 415 |
Release | 2021-02-04 |
Genre | Medical |
ISBN | 3030498441 |
Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information. Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.