Structural and Mechanistic Studies of the Iron(II)- and 2-oxoglutarate-dependent Dioxygenases
Title | Structural and Mechanistic Studies of the Iron(II)- and 2-oxoglutarate-dependent Dioxygenases PDF eBook |
Author | Edward Longbotham |
Publisher | |
Pages | |
Release | 2014 |
Genre | |
ISBN |
2-Oxoglutarate-Dependent Oxygenases
Title | 2-Oxoglutarate-Dependent Oxygenases PDF eBook |
Author | Christopher J Schofield |
Publisher | Royal Society of Chemistry |
Pages | 508 |
Release | 2015-05-06 |
Genre | Science |
ISBN | 1849739501 |
Since the discovery of the first examples of 2-oxoglutarate-dependent oxygenase-catalysed reactions in the 1960s, a remarkably broad diversity of alternate reactions and substrates has been revealed, and extensive advances have been achieved in our understanding of the structures and catalytic mechanisms. These enzymes are important agrochemical targets and are being pursued as therapeutic targets for a wide range of diseases including cancer and anemia. This book provides a central source of information that summarizes the key features of the essential group of 2-oxoglutarate-dependent dioxygenases and related enzymes. Given the numerous recent advances and biomedical interest in the field, this book aims to unite the latest research for those already working in the field as well as to provide an introduction for those newly approaching the topic, and for those interested in translating the basic science into medicinal and agricultural benefits. The book begins with four broad chapters that highlight critical aspects, including an overview of possible catalytic reactions, structures and mechanisms. The following seventeen chapters focus on carefully selected topics, each written by leading experts in the area. Readers will find explanations of rapidly evolving research, from the chemistry of isopenicillin N synthase to the oxidation mechanism of 5-methylcytosine in DNA by ten-eleven-translocase oxygenases.
2-Oxoglutarate-Dependent Oxygenases
Title | 2-Oxoglutarate-Dependent Oxygenases PDF eBook |
Author | Christopher Schofield |
Publisher | Royal Society of Chemistry |
Pages | 508 |
Release | 2015-04-23 |
Genre | Science |
ISBN | 1782621954 |
Since the discovery of the first examples of 2-oxoglutarate-dependent oxygenase-catalysed reactions in the 1960s, a remarkably broad diversity of alternate reactions and substrates has been revealed, and extensive advances have been achieved in our understanding of the structures and catalytic mechanisms. These enzymes are important agrochemical targets and are being pursued as therapeutic targets for a wide range of diseases including cancer and anemia. This book provides a central source of information that summarizes the key features of the essential group of 2-oxoglutarate-dependent dioxygenases and related enzymes. Given the numerous recent advances and biomedical interest in the field, this book aims to unite the latest research for those already working in the field as well as to provide an introduction for those newly approaching the topic, and for those interested in translating the basic science into medicinal and agricultural benefits. The book begins with four broad chapters that highlight critical aspects, including an overview of possible catalytic reactions, structures and mechanisms. The following seventeen chapters focus on carefully selected topics, each written by leading experts in the area. Readers will find explanations of rapidly evolving research, from the chemistry of isopenicillin N synthase to the oxidation mechanism of 5-methylcytosine in DNA by ten-eleven-translocase oxygenases.
Structural and Mechanistic Studies of Rieske Dioxygenases
Title | Structural and Mechanistic Studies of Rieske Dioxygenases PDF eBook |
Author | Andreas Karlsson |
Publisher | |
Pages | 77 |
Release | 2002 |
Genre | Multienzyme complexes |
ISBN | 9789157661517 |
Iron-containing Enzymes
Title | Iron-containing Enzymes PDF eBook |
Author | Sam P. De Visser |
Publisher | Royal Society of Chemistry |
Pages | 463 |
Release | 2011 |
Genre | Science |
ISBN | 1849731810 |
Mononuclear iron containing enzymes are important intermediates in bioprocesses and have potential in the industrial biosynthesis of specific products. This book features topical review chapters by leaders in this field and its various sub-disciplines.
Angiogenesis
Title | Angiogenesis PDF eBook |
Author | William D. Figg |
Publisher | Springer Science & Business Media |
Pages | 592 |
Release | 2008-05-24 |
Genre | Medical |
ISBN | 0387715185 |
Dr. Judah Folkman is considered the "father of angiogenesis." Because of Folkman's discovery and research, the possibilities of angiogenic therapy have broadened beyond cancer to many noncancerous diseases. Angiogenesis: An Integrative Approach from Science to Medicine is a comprehensive, concise summary of tumor angiogenesis. It is an up-to-date and authoritative reference for the angiogenesis field as it relates to oncology. This book represents the first collection in a volume of which Folkman is co-editor. Folkman has authored nearly 400 original papers and more than 100 book chapters.
Journal of Cell Science
Title | Journal of Cell Science PDF eBook |
Author | |
Publisher | |
Pages | 692 |
Release | 2003 |
Genre | Cytology |
ISBN |