With the new classification of chronic myeloproliferative disorders, and the rise of interest in molecularly targeted therapies, this timely text brings together international experts on the topic to discuss the current technologies and their implications for the treatment of patients. This title comprehensively covers chronic myeloid leukemia and Ph-negative chronic myeloproliferative disorders and is an essential resource for all practitioners in Hematologic Oncology.

Stress Field of the Earth’s Crust is based on lecture notes prepared for a course offered to graduate students in the Earth sciences and engineering at University of Potsdam. In my opinion, it will undoubtedly also become a standard reference book on the desk of most scientists working with rocks, such as geophysicists, structural geologists, rock mechanics experts, as well as geotechnical and petroleum en- neers. That is because this book is concerned with what is probably the most pe- liar characteristic of rock – its initial stress condition. Rock is always under a natural state of stress, primarily a result of the gravitational and tectonic forces to which it is subjected. Crustal stresses can vary regionally and locally and can reach in places considerable magnitudes, leading to natural or man-made mechanical failure. P- existing stress distinguishes rock from most other materials and is at the core of the discipline of “Rock Mechanics”, which has been developed over the last century. Knowledge of rock stress is fundamental to understanding faulting mechanisms and earthquake triggering, to designing stable underground caverns and prod- tive oil fields, and to improving mining methods and geothermal energy extraction, among others. Several books have been written on the subject, but none has atte- ted to be as all-encompassing as the one by Zang and Stephansson.

This publication contains three special lectures, six keynote addresses and sixty-eight technical papers presented at the symposium. The wide variety of topics covered are grouped in the proceedings according to subject.

A project was undertaken to determine how well acoustic emission (AE) techniques could be used to determine the existing stress state in rock and soil masses. It was found in rock that the Kaiser Effect (No AE until previous stress level EXCEEDED) was obeyed for short times (delay times) after stress application, but was not obeyed for delay times longer than about 100-1000 hours. In soil, the Kaiser effect was obeyed, but the effect of delay times was not investigated. These results apply to a very wide variety of rock and soil types. A Goodman rock jack was retrofitted with an AE transducer assembly and field tested in large discrete rock masses at a rock quarry and in bore holes in six different sites with varying rock types. This acoustic-rock jack functioned very well above and below the water table. The existing horizontal stresses, predicted from breaks in the AE versus applied stress curves, were of the same order (on the higher end) as those determined by more conventional mthods of determining the existing stress state. A Menard pressuremeter was retrofitted with an AE transducer assembly, and used in bore holes in the field in various soil types. Preliminary field work has shown this acoustic pressuremeter to work well to depths of 10 feet (only used above the water table so far). The existing horizontal (lateral) stresses predicted from the AE pressuremeter results were in the higher portion of the expected values.