"If you haven't had the good fortune to be coached by a strong leader or product coach, this book can help fill that gap and set you on the path to success." - Marty Cagan How do you know that you are making a product or service that your customers want? How do you ensure that you are improving it over time? How do you guarantee that your team is creating value for your customers in a way that creates value for your business? In this book, you'll learn a structured and sustainable approach to continuous discovery that will help you answer each of these questions, giving you the confidence to act while also preparing you to be wrong. You'll learn to balance action with doubt so that you can get started without being blindsided by what you don't get right. If you want to discover products that customers love-that also deliver business results-this book is for you.

The antiviral therapeutic area continues to rapidly generate meaningful new chemical entities; for example, for HIV alone more than 25 drugs have been approved, and in the next few years many individual drugs and single tablet regimens will be approved for the treatment of hepatitis C virus infection. The increasing success in the antiviral area could be due to targeting drugs at "non-self" genomes and to the patient population that is tolerant of manageable side effects and adaptable to inconvenient dosing. Aimed at medicinal chemists and emerging drug discovery scientists, the book is organized according to the various strategies deployed for the discovery and optimization of initial lead compounds. This book focuses on capturing tactical aspects of problem solving in antiviral drug design, an approach that holds special appeal for those engaged in antiviral drug development, but also appeals to the broader medicinal chemistry community based on its focus on tactical aspects of drug design.

Navigate the complex and multidisciplinary path of drug discovery procedures with Drug Discovery Strategies and Methods-a well-organized and timely reference that analyzes methods in target identification and validation, lead detection, compound optimization, and biological testing. This volume addresses challenges encountered during the discovery of new pharmaceutical candidates including the use of cutting-edge techniques utilized in drug design and development. It considers key elements in the drug design cycle ranging from appropriateness of targets and disease models to compound characterization, safety, and efficacy and the role of protein crystallography in structure-based drug design.

This book examines a key issue in current cognitive theories - the nature of representation. Each chapter is characterized by attempts to frame hot topics in cognitive development within the landscape of current developmental theorizing and the past legacy of genetic epistemology. The chapters address four questions that are fundamental to any developmental line of inquiry: How should we represent the workings and contents of the mind? How does the child construct mental models during the course of development? What are the origins of these models? and What accounts for the novelties that are the products and producers of developmental change? These questions are situated in a historical context, Piagetian theory, and contemporary researchers attempt to trace how they draw upon, depart from, and transform the Piagetian legacy to revisit classic issues such as the child's awareness of the workings of mental life, the child's ability to represent the world, and the child's growing ability to process and learn from experience. The theoretical perspectives covered include constructivism, connectionism, theory-theory, information processing, dynamical systems, and social constructivist approaches. The research areas span imitation, mathematical reasoning, biological knowledge, language development, and theory of mind. Written by major contributors to the field, this work will be of interest to students and researchers wanting a brief but in-depth overview of the contemporary field of cognitive development.

Personal, useful, actionable and grounded in research, this book will shift your thinking from "strategy development" to "strategy discovery" to enable you to deal with today’s business challenges, engage your staff and boost your business performance. Management teams and boards are facing disruption on all sides, from morphing customer preferences to the COVID pandemic to climate change. At the same time they are floundering in strategy confusion with too many concepts and not enough clarity. In this book, strategy expert and regular Harvard Business Review author Graham Kenny releases managers and directors from their strategy haze. His simple and effective framework allows managers to navigate the current maze of ideas and approaches and maximize their competitive advantage. Kenny’s readable style is equally effective: each chapter begins with an engaging story, then builds on this with cases, client examples, sidebars and more, ending with a series of action points to provide a pathway to success. CEOs, senior-level and middle managers across all functions and sectors, including private, public and not-for-profit organizations, who discuss and set strategy for their organization or business unit will appreciate the articulated framework, illustrative anecdotes and positive encouragement this book offers.

A wonderful work, addressed to scientists but deserving of a wider audience. A personal, purposeful, and passionate exposition about the subjective process that accompanies discovery--and how to choose a discovery-laden topic for research, how to find opportunities in science overlooked by others, and how to break out of the rut of mundane thinking. Annotation copyrighted by Book News, Inc., Portland, OR