This book provides a clear, comprehensible and up-to-date description of how Small Angle Scattering (SAS) can help structural biology researchers. SAS is an efficient technique that offers structural information on how biological macromolecules behave in solution. SAS provides distinct and complementary data for integrative structural biology approaches in combination with other widely used probes, such as X-ray crystallography, Nuclear magnetic resonance, Mass spectrometry and Cryo-electron Microscopy. The development of brilliant synchrotron small-angle X-ray scattering (SAXS) beam lines has increased the number of researchers interested in solution scattering. SAS is especially useful for studying conformational changes in proteins, highly flexible proteins, and intrinsically disordered proteins. Small-angle neutron scattering (SANS) with neutron contrast variation is ideally suited for studying multi-component assemblies as well as membrane proteins that are stabilized in surfactant micelles or vesicles. SAS is also used for studying dynamic processes of protein fibrillation in amyloid diseases, and pharmaceutical drug delivery. The combination with size-exclusion chromatography further increases the range of SAS applications. The book is written by leading experts in solution SAS methodologies. The principles and theoretical background of various SAS techniques are included, along with practical aspects that range from sample preparation to data presentation for publication. Topics covered include techniques for improving data quality and analysis, as well as different scientific applications of SAS. With abundant illustrations and practical tips, we hope the clear explanations of the principles and the reviews on the latest progresses will serve as a guide through all aspects of biological solution SAS. The scope of this book is particularly relevant for structural biology researchers who are new to SAS. Advanced users of the technique will find it helpful for exploring the diversity of solution SAS methods and applications. Chapter 3 of this book is available open access under a CC BY 4.0 license at link.springer.com.

You think you have a winning strategy. But do you? Executives are bombarded with bestselling ideas and best practices for achieving competitive advantage, but many of these ideas and practices contradict each other. Should you aim to be big or fast? Should you create a blue ocean, be adaptive, play to win—or forget about a sustainable competitive advantage altogether? In a business environment that is changing faster and becoming more uncertain and complex almost by the day, it’s never been more important—or more difficult—to choose the right approach to strategy. In this book, The Boston Consulting Group’s Martin Reeves, Knut Haanæs, and Janmejaya Sinha offer a proven method to determine the strategy approach that is best for your company. They start by helping you assess your business environment—how unpredictable it is, how much power you have to change it, and how harsh it is—a critical component of getting strategy right. They show how existing strategy approaches sort into five categories—Be Big, Be Fast, Be First, Be the Orchestrator, or simply Be Viable—depending on the extent of predictability, malleability, and harshness. In-depth explanations of each of these approaches will provide critical insight to help you match your approach to strategy to your environment, determine when and how to execute each one, and avoid a potentially fatal mismatch. Addressing your most pressing strategic challenges, you’ll be able to answer questions such as: • What replaces planning when the annual cycle is obsolete? • When can we—and when should we—shape the game to our advantage? • How do we simultaneously implement different strategic approaches for different business units? • How do we manage the inherent contradictions in formulating and executing different strategies across multiple businesses and geographies? Until now, no book brings it all together and offers a practical tool for understanding which strategic approach to apply. Get started today.

La stratégie d'entreprise, c'est le domaine où le droit à l'erreur coûte cher. Si cher même que l'entreprise peut en mourir. L'excellence dans l'action n'est pas un gage de succès si cette action s'engage dans une mauvaise direction. Agir et penser l'action sont deux temps différents. Cet ouvrage propose une méthode de raisonnement générique pour penser l'action. Le plus difficile en stratégie est de penser simplement ce qui justement ne nous paraît pas simple. La boussole stratégique présentée dans ces pages s'articule autour de quatre questions : • Quel avantage donne l'effet de taille pour une activité donnée ? • Quel est le potentiel de différenciation de l'activité ? • Quelle est la logique financière de son développement ? • Quels sont les rapports de forces dans la chaîne de valeur ajoutée ? Les réponses à ces questions permettent de préciser le terrain de jeu stratégique et les différentes voies possibles pour développer un avantage concurrentiel. Les dirigeants et décideurs pourront ainsi confronter l'analyse à leur intuition, et donc affiner leur réflexion stratégique.

Outlines an approach to high-performance problem solving and decision making that draws on insights from survival guides, pop culture, and other sources.

This study examines the record of French and EU interactions with China, Japan and Vietnam in the areas of economic exchanges, political security relations and human rights to establish if there has been a trend of converging 'European' politics and collective European conceptions of interest and identity. It argues that the utility and impact of EU institutions on French foreign policy behaviour is more significant than is commonly imagined or admitted, and that foreign policies of EU member states tend over the long term towards convergence.