An examination of chirality as an environmental phenomenon

Recently there has been growing concern about the hazards for man and his environment due to exposure to chemicals. One aspect receiving particular attention is that of the neglect of stereoselectivity in bioactive agents such as pesticides, drugs, etc. Mixtures of stereoisomers often contain 50 percent inactive material in the form of isomeric ballast. This ballast is pure environmental pollutant. Decisions as to whether the use of mixtures of stereoisomers is acceptable are only possible and acceptable if they are based on sound scientific information. It is the purpose of this volume to contribute to, and to disseminate, knowledge in this field. Written for workers in the field of pesticides, the book contains concise and basic information on stereoselectivity as a notable source of problems. Attention is paid to the involvement of stereoselectivity in important classes of pesticides as well as to pheromones and compounds derived from insect hormones with potential use in crop protection. Fundamentals of stereochemistry, stereoselective analytical methods, stereoselective synthesis and stereochemical aspects of the design of new compounds are also discussed.

Bisher gab es kein Buch, das sich speziell mit der Chiralität von Agrochemikalien beschäftigte, obwohl dieses Gebiet zunehmende Beachtung in der Industrie findet. Diese Darstellung der Chiralität bei Insektiziden, Fungiziden, Herbiziden und anderen Klassen von Agrochemikalien schließt diese Lücke. Synthese, Analytik, biologische Aktivität, Wirkprinzip, Toxikologie, Metabolismus und Umweltschicksal jeder besprochenen Verbindung werden diskutiert. (8/98)

Agents for control of animal pests. Fungicides and bactericides. Herbicides. Plant growth regulators. Formulation aids.

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