INSPIRE is a resource to help governments, international agencies, and non-government organisations prevent and respond to violence against children. It was developed by 10 international and U.S.-based agencies and includes strategy documents and implementation tools. This handbook provides guidance on how to choose and implement interventions based on specific needs and context, and is organised around the 7 key INSPIRE strategies: implementation and enforcement of laws; norms and values; safe environments; parent and caregiver support; income and economic strengthening; response and support services; and education and life skills. The handbook also provides an overview of implementation and impact indicators, drawn from the companion document 'INSPIRE indicator guidance and results framework'.