List of Contributors -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W

An international team of biologists, philosophers, and historians of science explores the critically important process of replication in biological and biomedical research Without replication, the trustworthiness of scientific research remains in doubt. Although replication is increasingly recognized as a central problem in many scientific disciplines, repeating the same scientific observations of experiments or reproducing the same set of analyses from existing data is remarkably difficult. In this important volume, an international team of biologists, philosophers, and historians of science addresses challenges and solutions for valid replication of research in medicine, ecology, natural history, agriculture, physiology, and computer science. After the introduction to important concepts and historical background, the book offers paired chapters that provide theoretical overviews followed by detailed case studies. These studies range widely in topics, from infectious-diseases and environmental monitoring to museum collections, meta-analysis, bioinformatics, and more. The closing chapters explicate and quantify problems in the case studies, and the volume concludes with important recommendations for best practices.

On their first journey away from the safety of their island home, two novice Singers learn important lessons when they must confront an evil Khizpriest and stop him from stealing the power of their life-controlling Songs.

Jay McInerney has written unique, witty, vinous essays for over a decade. Here, with his trademark flair and expertise, McInerney provides a master class in the almost infinite varieties of wine, creating a collage of the people and places that produce it all over the world, from historic past to the often confusing present. Stretching from France and South Africa to Australia and New Zealand, McInerney's tour is a comprehensive and thirst-inducing expedition that explores viticulture, investigates great champagne and delves into a vast array of styles, capturing the passion that so many people feel for the world of wine.

An impressive new collection from a poet whose previous book was a finalist for both the National Book Award and the National Book Critics Circle Award Taking its title from Heraclitus's most famous fragment, The River Twice is an elegiac meditation on impermanence and change. The world presented in these poems is a fluid one in which so much—including space and time, the subterranean realm of dreams, and language itself—seems protean, as the speaker's previously familiar understanding of the self and the larger systems around it gives way. Kathleen Graber’s poems wander widely, from the epistolary to the essayistic, shuffling the remarkable and unremarkable flotsam of contemporary life. One thought, one memory, one bit of news flows into the next. Yet, in a century devoted to exponentially increasing speed, The River Twice unfolds at the slow pace of a river bend. While the warm light of ideas and things flashes upon the surface, that which endures remains elusive—something glimpsed only for an instant before it is gone.

Superficially, Wittgenstein and Heidegger seem worlds apart: they worked in different philosophical traditions, seemed mostly ignorant of one another's work, and Wittgenstein's terse aphorisms in plain language could not be farther stylistically from Heidegger's difficult prose. Nevertheless, Wittgenstein's Philosophical Investigations and Heidegger's Being and Time share a number of striking parallels. In particular, this book shows that both authors manifest a similar concern with authenticity. David Egan develops this position in three stages. Part One explores the emphasis both philosophers place on the everyday, and how this emphasis brings with it a methodological focus on recovering what we already know rather than advancing novel theses. Part Two argues that the dynamic of authenticity and inauthenticity in Being and Time finds homologies in Philosophical Investigations. Here Egan particularly articulates and defends a conception of authenticity in Wittgenstein that emphasizes the responsiveness and reciprocity of play. Part Three considers how both philosophers' conceptions of authenticity apply reflexively to their own work: each is concerned not only with the question of what it means to exist authentically but also with the question of what it means to do philosophy authentically. For both authors, the problematic of authenticity is intimately linked to the question of philosophical method.

This book tells the dramatic story of Crispr and the potential impact of this gene-editing technology.