One of the greatest unmet challenges in conservation biology is the genetic management of fragmented populations of threatened animal and plant species. More than a million small, isolated, population fragments of threatened species are likely suffering inbreeding depression and loss of evolutionary potential, resulting in elevated extinction risks. Although these effects can often be reversed by re-establishing gene flow between population fragments, managers very rarely do this. On the contrary, genetic methods are used mainly to document genetic differentiation among populations, with most studies concluding that genetically differentiated populations should be managed separately, thereby isolating them yet further and dooming many to eventual extinction Many small population fragments are going extinct principally for genetic reasons. Although the rapidly advancing field of molecular genetics is continually providing new tools to measure the extent of population fragmentation and its genetic consequences, adequate guidance on how to use these data for effective conservation is still lacking. This accessible, authoritative text is aimed at senior undergraduate and graduate students interested in conservation biology, conservation genetics, and wildlife management. It will also be of particular relevance to conservation practitioners and natural resource managers, as well as a broader academic audience of conservation biologists and evolutionary ecologists.

Human Population Genetics and Genomics provides researchers/students with knowledge on population genetics and relevant statistical approaches to help them become more effective users of modern genetic, genomic and statistical tools. In-depth chapters offer thorough discussions of systems of mating, genetic drift, gene flow and subdivided populations, human population history, genotype and phenotype, detecting selection, units and targets of natural selection, adaptation to temporally and spatially variable environments, selection in age-structured populations, and genomics and society. As human genetics and genomics research often employs tools and approaches derived from population genetics, this book helps users understand the basic principles of these tools. In addition, studies often employ statistical approaches and analysis, so an understanding of basic statistical theory is also needed. - Comprehensively explains the use of population genetics and genomics in medical applications and research - Discusses the relevance of population genetics and genomics to major social issues, including race and the dangers of modern eugenics proposals - Provides an overview of how population genetics and genomics helps us understand where we came from as a species and how we evolved into who we are now

The Arthur M. Sackler Colloquia of the National Academy of Sciences address scientific topics of broad and current interest, cutting across the boundaries of traditional disciplines. Each year, four or five such colloquia are scheduled, typically two days in length and international in scope. Colloquia are organized by a member of the Academy, often with the assistance of an organizing committee, and feature presentations by leading scientists in the field and discussions with a hundred or more researchers with an interest in the topic. Colloquia presentations are recorded and posted on the National Academy of Sciences Sackler colloquia website and published on CD-ROM. These Colloquia are made possible by a generous gift from Mrs. Jill Sackler, in memory of her husband, Arthur M. Sackler.

LANDSCAPE GENETICS: CONCEPTS, METHODS, APPLICATIONS LANDSCAPE GENETICS: CONCEPTS, METHODS, APPLICATIONS Edited by Niko Balkenhol, Samuel A. Cushman, Andrew T. Storfer, Lisette P. Waits Landscape genetics is an exciting and rapidly growing field, melding methods and theory from landscape ecology and population genetics to address some of the most challenging and urgent ecological and evolutionary topics of our time. Landscape genetic approaches now enable researchers to study in detail how environmental complexity in space and time affect gene flow, genetic drift, and local adaptation. However, learning about the concepts and methods underlying the field remains challenging due to the highly interdisciplinary nature of the field, which relies on topics that have traditionally been treated separately in classes and textbooks. In this edited volume, some of the leading experts in landscape genetics provide the first comprehensive introduction to underlying concepts, commonly used methods, and current and future applications of landscape genetics. Consistent with the interdisciplinary nature of the field, the book includes textbook-like chapters that synthesize fundamental concepts and methods underlying landscape genetics (Part 1), chapters on advanced topics that deserve a more in-depth treatment (Part 2), and chapters illustrating the use of concepts and methods in empirical applications (Part 3). Aimed at beginning landscape geneticists and experienced researchers alike, this book will be helpful for all scientists and practitioners interested in learning, teaching, and applying landscape genetics.

The dominant trees of Australia, eucalypts make up a remarkable genus. This authoritative volume provides current reviews by active researchers of many disciplines, including evolutionary history, genetics, distribution and modelling, the relationship of eucalypts to fire and nutrients, ecophysiology, pollination and reproductive ecology, interactions between eucalypts and other co-existing biota (including fungi, invertebrates and vertebrates), and conservation and management. Together these reviews shed light on the reasons for the great success of eucalypts in Australian environments, and provide a comprehensive summary for comparison with the ecology of major woody plant genera in other continents. This volume is of particular relevance to Australian ecologists, but also provides a stimulating perspective to students of vegetation ecology in all continents.

Genetics and Evolution of Infectious Diseases, Third Edition discusses the evolving field of infectious diseases and their continued impact on the health of populations, especially in resource-limited areas of the world where they must confront the dual burden of death and disability due to infectious and chronic illnesses. Although substantial gains have been made in public health interventions for the treatment, prevention, and control of infectious diseases, in recent decades the world has witnessed the emergence of the human immunodeficiency virus (HIV) and the COVID-19 pandemic, increasing antimicrobial resistance, and the emergence of many new bacterial, fungal, parasitic, and viral pathogens. Fully updated and revised, this new edition presents the consequences of such diseases, the evolution of infectious diseases, the genetics of host-pathogen relationship, and the control and prevention strategies that are, or can be, developed. This book offers valuable information to biomedical researchers, clinicians, public health practitioners, decisions-makers, and students and postgraduates studying infectious diseases, microbiology, medicine, and public health that is relevant to the control and prevention of neglected and emerging worldwide diseases. - Takes an integrated approach to infectious diseases - Provides the latest developments in the field of infectious diseases - Focuses on the contribution of evolutionary and genomic studies for the study and control of transmissible diseases - Includes updated and revised contributions from leading authorities, along with six new chapters