Statistical Genetics in Infectious Disease Susceptibility
Title | Statistical Genetics in Infectious Disease Susceptibility PDF eBook |
Author | John Kenneth Baillie |
Publisher | |
Pages | 302 |
Release | 2013 |
Genre | |
ISBN |
Genetics of Infectious Disease Susceptibility
Title | Genetics of Infectious Disease Susceptibility PDF eBook |
Author | Tjeerd G. Kimman |
Publisher | Springer Science & Business Media |
Pages | 252 |
Release | 2001-07-31 |
Genre | Medical |
ISBN | 9780792371557 |
"Progress in the molecular analysis of genetic susceptibility to human and animal infectious diseases has been very rapid over the last few years. Several genes involved in resistance to HIV/AIDS, tuberculosis, malaria, viral hepatitis, herpesvirus infections, prion diseases, and several others have now been identified, and their functions have partly or completely been elucidated." "This book covers the most recent advances in the field and explores how progress in knowing the genetic basis of infectious diseases could lead to new insights into understanding and combating them."--BOOK JACKET.
Genetic Susceptibility to Infectious Diseases
Title | Genetic Susceptibility to Infectious Diseases PDF eBook |
Author | Richard A. Kaslow |
Publisher | Oxford University Press |
Pages | 464 |
Release | 2008 |
Genre | Medical |
ISBN | 0195174909 |
Infectious diseases are commonly regarded as a distinct category, with different causes and patterns than chronic or genetic disease. But in fact there are many varieties of genetic susceptibility to infection, the subject of this book, which will be divided into three sections: 1) concepts and methods, 2) genes and pathophysiologic mechanisms, and 3) infectious agents and diseases. No currently plubished text on either genetics or infectious diseases focuses on the genetic aspects of the special relationship between host and pathogen in the way envisioned for Section 1. No other work on the selected genes regulating immunity deals as systematically with the sequence variation/function relationships most pertinent to infection as planned for Section 2. And no other book gives as meaningful a picture of how these genes operate in infectious disease as Section 3 will.
Modeling Infectious Disease Parameters Based on Serological and Social Contact Data
Title | Modeling Infectious Disease Parameters Based on Serological and Social Contact Data PDF eBook |
Author | Niel Hens |
Publisher | Springer Science & Business Media |
Pages | 300 |
Release | 2012-10-24 |
Genre | Medical |
ISBN | 1461440726 |
Mathematical epidemiology of infectious diseases usually involves describing the flow of individuals between mutually exclusive infection states. One of the key parameters describing the transition from the susceptible to the infected class is the hazard of infection, often referred to as the force of infection. The force of infection reflects the degree of contact with potential for transmission between infected and susceptible individuals. The mathematical relation between the force of infection and effective contact patterns is generally assumed to be subjected to the mass action principle, which yields the necessary information to estimate the basic reproduction number, another key parameter in infectious disease epidemiology. It is within this context that the Center for Statistics (CenStat, I-Biostat, Hasselt University) and the Centre for the Evaluation of Vaccination and the Centre for Health Economic Research and Modelling Infectious Diseases (CEV, CHERMID, Vaccine and Infectious Disease Institute, University of Antwerp) have collaborated over the past 15 years. This book demonstrates the past and current research activities of these institutes and can be considered to be a milestone in this collaboration. This book is focused on the application of modern statistical methods and models to estimate infectious disease parameters. We want to provide the readers with software guidance, such as R packages, and with data, as far as they can be made publicly available.
Statistical Methods in Genetic Epidemiology
Title | Statistical Methods in Genetic Epidemiology PDF eBook |
Author | Duncan C. Thomas |
Publisher | Oxford University Press |
Pages | 458 |
Release | 2004-01-29 |
Genre | Medical |
ISBN | 0199748055 |
This well-organized and clearly written text has a unique focus on methods of identifying the joint effects of genes and environment on disease patterns. It follows the natural sequence of research, taking readers through the study designs and statistical analysis techniques for determining whether a trait runs in families, testing hypotheses about whether a familial tendency is due to genetic or environmental factors or both, estimating the parameters of a genetic model, localizing and ultimately isolating the responsible genes, and finally characterizing their effects in the population. Examples from the literature on the genetic epidemiology of breast and colorectal cancer, among other diseases, illustrate this process. Although the book is oriented primarily towards graduate students in epidemiology, biostatistics and human genetics, it will also serve as a comprehensive reference work for researchers. Introductory chapters on molecular biology, Mendelian genetics, epidemiology, statistics, and population genetics will help make the book accessible to those coming from one of these fields without a background in the others. It strikes a good balance between epidemiologic study designs and statistical methods of data analysis.
Systems Genetics
Title | Systems Genetics PDF eBook |
Author | Klaus Schughart |
Publisher | Humana |
Pages | 0 |
Release | 2016-12-08 |
Genre | Medical |
ISBN | 9781493964253 |
This volume focuses on the use of system genetic methods and the use of murine models to study the role of gene variants and environmental factors on human health and disease—what is now often called personalized or precision health care. The protocols in this book will help readers analyze genetic causes of heritable variation across a wide range of systems and traits using rodent models. The chapters in this book are separated into three sections that cover: 1) resources for systems genetics; 2) tools for analysis and integration in systems genetics; and 3) systems genetics use cases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and tools, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and thorough, Systems Genetics: Methods and Protocols is a valuable resource for anyone who is interested in this diverse field.
Handbook of Infectious Disease Data Analysis
Title | Handbook of Infectious Disease Data Analysis PDF eBook |
Author | Leonhard Held |
Publisher | CRC Press |
Pages | 472 |
Release | 2019-11-07 |
Genre | Medical |
ISBN | 1351839314 |
Recent years have seen an explosion in new kinds of data on infectious diseases, including data on social contacts, whole genome sequences of pathogens, biomarkers for susceptibility to infection, serological panel data, and surveillance data. The Handbook of Infectious Disease Data Analysis provides an overview of many key statistical methods that have been developed in response to such new data streams and the associated ability to address key scientific and epidemiological questions. A unique feature of the Handbook is the wide range of topics covered. Key features Contributors include many leading researchers in the field Divided into four main sections: Basic concepts, Analysis of Outbreak Data, Analysis of Seroprevalence Data, Analysis of Surveillance Data Numerous case studies and examples throughout Provides both introductory material and key reference material