The objective of this study was to develop a dynamic three-dimensional subject specific computational knee model by using finite element method and validate the finite element model using a validated multi-body model developed in MSC - ADAMS. The geometric input data required to create subject specific model was obtained from Magnetic Resonance Imaging of the specimen knee. The kinematic input data was obtained from simulation of the knee in a dynamic knee simulator. The three dimensional knee model was created using MR images of specimen knee. Hexahedral element meshing was performed for the construction of finite element model and ABAQUS is used for analysis purpose. Various studies were performed to identify the effects of the ABAQUS input parameters on the accuracy of the results. The finite element (FE) model was then simulated for the kinematic input obtained from a ten second squat cycle and output values for reaction force in the fixed part were recorded. The validation of FR model was conducted by comparing the results with the validated ADAMS model. Finally future improvements are suggested.

In recent years, numerous scientific investigations have studied the anatomical, biomechanical and functional role of structures involved in the human knee joint. The Finite Element Method (FEM) has been seen as an interesting tool to study and simulate biosystems. It has been extensively used to analyse the knee joint and various types of knee diseases and rehabilitation procedures such as the High Tibial Osteotomy (HTO). This work presents a review on FEM analysis of the human knee joint and HTO knee surgery, and discusses how adequate this computational tool is for this type of biomedical applications. Hence, various studies addressing the knee joint based on Finite Element Analysis (FEA) are reviewed, and an overview of clinical and biomechanical studies on the optimization of the correction angle of the postoperative knee surgery is provided.

Cartilage, Tissue and Knee Joint Biomechanics: Fundamentals, Characterization and Modelling is a cutting-edge multidisciplinary book specifically focused on modeling, characterization and related clinical aspects. The book takes a comprehensive approach towards mechanics, fundamentals, morphology and properties of Cartilage Tissue and Knee Joints. Leading researchers from health science, medical technologists, engineers, academics, government, and private research institutions across the globe have contributed to this book. This book is a very valuable resource for graduates and postgraduates, engineers and research scholars. The content also includes comprehensive real-world applications. As a reference for the total knee arthroplasty, this book focuses deeply on existing related theories (including: histology, design, manufacturing and clinical aspects) to assist readers in solving fundamental and applied problems in biomechanical and biomaterials characterization, modeling and simulation of human cartilages and cells. For biomedical engineers dealing with implants and biomaterials for knee joint injuries, this book will guide you in learning the knee anatomy, range of motion, surgical procedures, physiological loading and boundary conditions, biomechanics of connective soft tissues, type of injuries, and more. - Provides a comprehensive resource on the knee joint and its connective soft tissues; content included spans biomechanics, biomaterials, biology, anatomy, imaging and surgical procedure - Covers ISO and FDA based regulatory control and compliance in the manufacturing process - Includes discussions on the relationship between knee anatomical parameters and knee biomechanics

This is an open access book. Faculty of Mechanics is organizing International Conference of Mechanical Engineering, ICOME 2022 that will be held on 18th–20th of May 2022. The aim of the conference is to provide opportunities for the participants to: Gain insight into the cutting-edge technologies and ideas for future developments; Update their skills and knowledge by attending focused technical sessions; Network with potential new partners, clients and suppliers; View the latest technology products and services in the technical exhibition. The conference aims to bring together scientists, engineers, manufacturers and users from all over the world to discuss common theoretical and practical problems, describe scientific applications and explore avenues for the future researches in the area of Mechanical engineering.

Computational Modeling in Bioengineering and Bioinformatics promotes complementary disciplines that hold great promise for the advancement of research and development in complex medical and biological systems, and in the environment, public health, drug design, and so on. It provides a common platform by bridging these two very important and complementary disciplines into an interactive and attractive forum. Chapters cover biomechanics and bioimaging, biomedical decision support system, data mining, personalized diagnoses, bio-signal processing, protein structure prediction, tissue and cell engineering, biomedical image processing, analysis and visualization, high performance computing and sports bioengineering. The book's chapters are the result of many international projects in the area of bioengineering and bioinformatics done at the Research and Development Center for Bioengineering BioIRC and by the Faculty of Engineering at the University of Kragujevac, Serbia. - Presents recent advances at the crossroads of biomedical engineering and bioinformatics, one of the hottest areas in biomedical and clinical research - Discusses a wide range of leading-edge research topics, including biomechanics and bioimaging, biomedical decision support systems, data mining, personalized diagnoses, bio-signal processing, protein structure prediction, tissue and cell engineering, amongst others - Includes coverage of biomechanical, bioengineering and computational methods of treatment and diagnosis