This is the ideal book for anyone contemplating starting a career in, or shifting their career to, studying the dynamics that drive cancer progression and its response to therapy. Topics include the theory and population genetics of cancers, genetic diversity within tumors (intra-tumor heterogeneity), understanding how mutant clones expand in tissues, the role of cancer stem cells in the dynamics of tumors, the evolution of metastasis, and how to improve cancer therapy by addressing the evolution of cancers in response to our interventions. There are also chapters on the patterns of cancer susceptibility in humans due to a mismatch between our modern environment and the environment in which our ancestors evolved, as well as a chapter on the evolution of cancer suppression mechanisms that have evolved in different species, particularly the large long-lived animals like elephants and whales that are better at suppressing cancers than humans. This book serves as a primer on the evolutionary and ecological theory of cancer- the framework upon which all the details of cancer may be hung. It is ideal for oncologists and cancer researchers interested in evolutionary theory, and evolutionary biologists and ecologists interested in gaining insights into cancer development and prevention.

* Professor David Lordkipanidze, Director of the Georgian National Museum (GNM) in Tibilisi, illuminates his personal highlights from the collection with his considerable expertise * The GNM tells the story of Georgia's history from the Bronze Age to the early 20th century * The first Georgian addition to Scala's successful Director's Choice series Established in 2004, the Georgian National Museum (GNM) in Tbilisi encompasses 20 museums and cultural institutions. The main site tells the story of Georgia's history from the Bronze Age to the early 20th century. It's the story of 'The Land of the Golden Fleece' - the ancient Kingdom of Colchis, whose ingenious gold, silver and precious stonework can be seen in the Treasury. The Greek, Ottoman and Iranian Influence visible in many of the treasures is testament to Georgia's role as a crossroads through the centuries. The GNM also records Georgia's modern history, tracing the rise of a united Georgian state, how it resisted Soviet Occupation and survived the Red Terror. However, perhaps most significantly of all, here visitors can come face-to-face with the earliest homonid known to have left Africa - a 1.8 million-year-old discovery made by the GNM's Director, Professor David Lordkipanidze, that has rewritten our understanding of early European humanity. In this beautifully illustrated book, Professor Lordkipanidze illuminates his personal highlights from the collection with his considerable expertise.