Targeted by a mad scientist's deadly serum, these outcasts band together to uncover the truth and to fight back. Spire City is home to mighty machines of steam power and clockwork, and giant beetles pull picturesque carriages over cobbled streets. But there is a darker secret behind these wonders. A deadly infection, created by a mad scientist, is spreading through the city, targeting the poor and powerless, turning them slowly into animals. A group of those infected by the serum join together to survive, to trick the wealthy out of their money, and to fight back. This lyrical fantasy will transport you to a steampunk world of weird and strange wonder. Come explore!

The Oxford Handbook of Health Psychology brings together preeminent experts to provide a comprehensive view of key concepts, tools, and findings of this rapidly expanding core discipline.

Though recent breakthroughs in research advance care with each day, the population of HIV-infected individuals continues to grow globally, leaving them particularly susceptible to additional STDs that are complicated by their immunocompromised state. This text is the only book to provide a comprehensive and state-of-the-art review of issues relevant to STI care in the HIV-infected adult, adolescent, and transgendered populations. Written by experts in the field, HIV in HIV-Infected Adults and Adolescents approaches these unique needs through its review of sexual history, synergies between STIs and HIV, epidemiology, issues specific for HIV-infected individuals, clinical presentation, diagnosis and management considerations for ten common STIs, and prevention strategies. Each topic includes a case-based presentation and the most current CDC-recommended STI treatment regimens. Sexually Transmitted Infections in HIV-Infected Adults and Special Populations is the ultimate resource for any physician treating adults and special populations with HIV, including HIV clinicians, sexual health specialists, general internists, family medicine practitioners, infectious diseases specialists, advanced practice clinicians, and physicians.

Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Periprosthetic joint infection (PJI) is among the most serious complications in the field of endoprosthetics. The number of PJIs is increasing worldwide and poses a real interdisciplinary challenge for everyone involved. For the patient concerned, it is necessary to promptly work out an adequate therapy solution to fight off the infection. Both the clinical experience of the surgeon and the proper diagnostic processes are prerequisite for the reliable detection and identification of an infection. The microbiologist is responsible for identifying the causative germs by screening the patient’s synovial fluid and tissue samples. Based on the findings and subsequent resistance testing, the infectious disease specialist can recommend the appropriate antibiotic therapy. Furthermore, the clinical pharmacist is consulted regularly throughout the therapy to discuss the risk of potential drug interactions. The surgeon will proceed with the revision surgery, following defined algorithms. Adequate radical debridement of infected and necrotic surrounding tissue is the most important step towards a successful cure of the infection. Accompanying the surgery, anti-infective agents are given systemically and locally. While systemic application of anti-infectives mainly reduces the number of haematogenic-spreading planktonic germs, local application immediately forms a colonization barrier and protects the implant from sessile biofilm formation. Concurrently, antibiotics are actively released from the implant, resulting in local germ reduction. Thus, local agents are embedded in the concept of surgical PJI treatment as a reliable adjuvant measure and they sustainably support the successful outcome. In one-stage procedures, local agents are released from specialized antibiotic-loaded bone cements, while in two- or multi-stage procedures, local agents are released from corresponding temporary spacers (interim prostheses). Even from an economic standpoint, the combination of systemic and local agent application is meaningful. Furthermore, there are some interesting trends towards the coating of metallic implants to protect against biofilm formation on the implant surface. On the basis of their personal experience, specialists from all over the world present, explain and discuss preventive approaches, appropriate diagnostic strategies for detection, reproducible effective surgical treatments as well as the economic impact of PJI. The reader can use this book as a solid platform for comparing their own approach to PJI treatment with the specialists’ recommendations.