Collects Amazing Spider-Man (1963) #13, #66-67 And #141-142; Web Of Spider-Man (1985) #90; Friendly Neighborhood Spider-Man (2005) #11-13; Amazing Spider-Man (1999) #618-620; And Material From Peter Parker, The Spectacular Spider-Man (1976) #50-51. When Spider-Man battles Mysterio, the stakes are far more deadly than just smoke and mirrors! Find out exactly how dangerous the master of illusion can be in this collection of Spidey’s greatest showdowns with one of his oldest foes! Relive Quentin Beck’s sinister, Steve Ditko-drawn debut — and larger-than-life battles illustrated by John Romita Sr., Ross Andru, Marcos Martin and more! Mysterio’s mists and mysteries plague Peter Parker in wicked ways, from shrinking him to six inches tall to seemingly summoning all of Spidey’s greatest foes! But is it always Beck under the iconic fishbowl helmet — or are there multiple Mysterios? And can even death stop his deceptions?!

Mysterio is the master of illusions and he has convinced the world that Spider-Man is a Super Villain! Can Spider-Man prove that he's a hero and take down this clever trickster?

Collects Amazing Spider-Man Annual #1 Amazing Spider-Man #334-339. When still in high school, the Amazing Spider-Man faced one of his most chilling challenges when six of his most nerve-wracking nemeses formed the Sinister Six! Years later, Doctor Octopus reunites the team for his most remarkable racket yet, and time has made them deadlier than ever!

Collects Ultimate Spider-Man #112-117. Peter and his Aunt May have perhaps the most important conversation of Peter's life. And Spider-Man is on the call when there is a huge explosion in the side of the Triskelion - the side housing superhuman criminals. From the acrid smoke emerges a man seething with vengeance - a man who wants Peter Parker dead...the Green Goblin!

Collects Amazing Spider-Man (1963) #258, 300, 315-317, 332-333, 346-347, 388 (B story); Web of Spider-Man (1985) #1; Avengers: Deathtrap – the Vault (1991); Darkhawk (1991) #13-14; material from Amazing Spider-Man Annual (1964) #25-26; Web of Spider-Man Annual (1985) #7-8; Spectacular Spider-Man Annual (1979) #12. Venom goes Epic! When Spider-Man learns that his black costume is secretly an alien symbiote, he rejects the suit — and the spurned creature soon finds a new host! Disgraced reporter Eddie Brock has reasons of his own to hate Spider-Man, and together the two merge into the twisted engine of revenge known as Venom —and a rivalry for the ages begins! Venom has the same powers as Spider-Man — but he’s bigger, stronger and doesn’t trigger his spider-sense. And he knows Spidey’s secret identity! Against such a dangerous, determined and deadly foe, how far will Spider-Man have to go to survive?