The life of a traveling merchant is a lonely one, a fact with which Kraft Lawrence is well acquainted. Wandering from town to town with just his horse, cart, and whatever wares have come his way, the peddler has pretty well settled into his routine-that is, until the night Lawrence finds a wolf goddess asleep in his cart. Taking the form of a fetching girl with wolf ears and a tail, Holo has wearied of tending to harvests in the countryside and strikes up a bargain with the merchant to lend him the cunning of "Holo the Wisewolf" to increase his profits in exchange for taking her along on his travels. What kind of businessman could turn down such an offer? Lawrence soon learns, though, that having an ancient goddess as a traveling companion can be a bit of a mixed blessing. Will this wolf girl turn out to be too wild to tame?

Lawrence and Holo have settled into an idyllic life together after opening the Spice and Wolf bathhouse, but their happy marriage is suddenly intruded upon by an unexpected guest. During Nyohhira's sleepy off-season, the gruff stranger wanders alone from door to door as if in search of fleeting memories from long ago. Soon after his silent arrival, rumors about the possible construction of a rival hot spring village begin to spread. To protect their new home, the wise wolf and the cunning merchant return to the town of Svernel, but what they find there may spell the end of their adventures for good...

The young man Col and the daughter of the Wisewolf, Myuri, survived the scripture riots in the port town of Atiph. Col spends intense days being pined for after Myuri tells him about her love. Meanwhile, Heir Hyland commissions them for another next job. In the coming war with the Church's forces, control over the strait between the Kingdom of Winfiel and the mainland will play a crucial role. While Myuri is excited for a new adventure, Col cannot hide his unease after hearing about potential heresy among certain pirates for their faith in the "Black-Mother"!

As Holo and Lawrence begin the final leg of their journey, Lawrence decides to accompany Holo to her ancient home of Yoitsu, if only to forestall their parting just a bit longer. Boarding a ship from the port of Lenos (much to the chagrin of the wisewolf, who is none too fond of water!), the pair's fate becomes entangled with that of a boy named Col, whose tale of his circumstances - combined with the gossip of the sailors - leads to a shocking revelation about Holo's homeland!

Continuing their journey north, Lawrence and Holo stop in the village of Tereo in hopes of finding a local abbey where they might uncover more information regarding the fate of Holo's ancient home, Yoitsu. Soon after their arrival, though, the companions are caught up in a local dispute between Tereo and the neighboring town of Enberch that could cost Lawrence and Holo both their fortunes and their lives! With the Wisewolf's help, can Lawrence devise a way to save an entire town from ruin - and his skin and that of his traveling companion in the process?

The young man Col dreams of one day joining the holy clergy and departs on a journey from the bathhouse "The Spice and Wolf Inn," owned by his savior, Lawrence. The Winfiel Kingdom's prince has invited him to help correct the sins of the church. But as his travels begin, Col discovers in his luggage a young girl with a wolf's ears and tail named Myuri who stowed away for the ride! In the past, Col had accompanied the wisewolf Holo and the traveling merchant Lawrence on their own wanderings, eventually growing up alongside their daughter, Myuri as siblings. But as Col prepared to set off, Myuri opposed his departure and so she secretly ran away from home to join him! This is the story of Wolf and Parchment, and the pair's travels that will someday change the world!

In a break from Lawrence and Holo's ongoing adventures, author Isuna Hasekura presents "Side Colors," a series of short vignettes focusing on the fans' favorite characters.