The field of Large Eddy Simulations is reaching a level of maturity that brings this approach to the mainstream of engineering computations, while it opens opportunities and challenges. The main objective of this volume is to bring together leading experts in presenting the state-of-the-art and emerging approaches for treating complex effects in LES. A common theme throughout is the role of LES in the context of multiscale modeling and simulation.

This book addresses nearly all aspects of the state of the art in LES & DNS of turbulent flows, ranging from flows in biological systems and the environment to external aerodynamics, domestic and centralized energy production, combustion, propulsion as well as applications of industrial interest. Following the advances in increased computational power and efficiency, several contributions are devoted to LES & DNS of challenging applications, mainly in the area of turbomachinery, including flame modeling, combustion processes and aeroacoustics. The book includes work presented at the tenth Workshop on 'Direct and Large-Eddy Simulation' (DLES-10), which was hosted in Cyprus by the University of Cyprus, from May 27 to 29, 2015. The goal of the workshop was to establish a state of the art in DNS, LES and related techniques for the computation and modeling of turbulent and transitional flows. The book is of interest to scientists and engineers, both in the early stages of their career and at a more senior level.

This book reports the latest development and trends in the low Re number aerodynamics, transition from laminar to turbulence, unsteady low Reynolds number flows, experimental studies, numerical transition modelling, control of low Re number flows, and MAV wing aerodynamics. The contributors to each chapter are fluid mechanics and aerodynamics scientists and engineers with strong expertise in their respective fields. As a whole, the studies presented here reveal important new directions toward the realization of applications of MAV and wind turbine blades.

This book presents contributions to the 19th biannual symposium of the German Aerospace Aerodynamics Association (STAB) and the German Society for Aeronautics and Astronautics (DGLR). The individual chapters reflect ongoing research conducted by the STAB members in the field of numerical and experimental fluid mechanics and aerodynamics, mainly for (but not limited to) aerospace applications, and cover both nationally and EC-funded projects. Special emphasis is given to collaborative research projects conducted by German scientists and engineers from universities, research-establishments and industries. By addressing a number of cutting-edge applications, together with the relevant physical and mathematics fundamentals, the book provides readers with a comprehensive overview of the current research work in the field. Though the book’s primary emphasis is on the aerospace context, it also addresses further important applications, e.g. in ground transportation and energy.

The book presents a snapshot of the state-of-art in the field of turbulence modeling and covers the latest developments concerning direct numerical simulations, large eddy simulations, compressible turbulence, coherent structures, two-phase flow simulation and other related topics. It provides readers with a comprehensive review of both theory and applications, describing in detail the authors’ own experimental results. The book is based on the proceedings of the third Turbulence and Interactions Conference (TI 2012), which was held on June 11-14 in La Saline-les-Bains, La Réunion, France and includes both keynote lectures and outstanding contributed papers presented at the conference. This multifaceted collection, which reflects the conference ́s emphasis on the interplay of theory, experiments and computing in the process of understanding and predicting the physics of complex flows and solving related engineering problems, offers a practice-oriented guide for students, researchers and professionals in the field of computational fluid dynamics, turbulence modeling and related areas.

This book is intended for self-study or as a companion of lectures delivered to post-graduate students on the subject of the computational prediction of complex turbulent flows. There are several books in the extensive literature on turbulence that deal, in statistical terms, with the phenomenon itself, as well its many manifestations in the context of fluid dynamics. Statistical Turbulence Modelling for Fluid Dynamics — Demystified differs from these and focuses on the physical interpretation of a broad range of mathematical models used to represent the time-averaged effects of turbulence in computational prediction schemes for fluid flow and related transport processes in engineering and the natural environment. It dispenses with complex mathematical manipulations and instead gives physical and phenomenological explanations. This approach allows students to gain a 'feel' for the physical fabric represented by the mathematical structure that describes the effects of turbulence and the models embedded in most of the software currently used in practical fluid-flow predictions, thus counteracting the ill-informed black-box approach to turbulence modelling. This is done by taking readers through the physical arguments underpinning exact concepts, the rationale of approximations of processes that cannot be retained in their exact form, and essential calibration steps to which the resulting models are subjected by reference to theoretically established behaviour of, and experimental data for, key canonical flows.

Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments. ? Considers the healthcare needs driving the field, and where inhaled drugs could have the maximum impact ? Gives a concise account of the state of the art in key areas and technologies such as device and formulation technologies, clinically relevant in vitro performance assessment, medical imaging, as well as in silico modelling and simulation ? Articulates how the combination of in vitro product performance data, medical imaging and simulations technologies in the framework of large scale in silico pre-clinical trials could revolutionize the field ? Provides systematic and thorough referencing to sources offering a more-in-depth analysis of technical issues