"The Dream Zone": King Acorn's condition is worsening, and even the savvy DOCTOR QUACK can't seem to find a cure! It seems the only hope is the "Electro-Ecellographic Memory Inducer," which will allow Sonic to travel into the King's dreaming mind to communicate! Can Sonic somehow convince the King to fight the crystalization process that's ravaging his body? Or is the whole plan just a pipe dream?

After 30 years of going fast, it’s time for fans to celebrate the speediest hedgehog of all time! It’s an unbelievable birthday celebration for Sonic the Hedgehog with his first Classic Sonic special! First, in “Seasons of Chaos” by longtime Sonic scribe Ian Flynn and artists Aaron Hammerstrom & Reggie Graham, Sonic goes on an adventure from pleasant spring valleys to wintry wonderlands in search of the Chaos Emeralds. But Sonic’s not alone, with a little help from his friends Miles “Tails” Prower, Knuckles the Echidna, Amy Rose, Mighty the Armadillo, and Ray the Flying Squirrel, they’ll race, fight, and fly their way to victory against the baddest of baddies! Then, in “Dr. Eggman’s Birthday,” the vile, villainous Dr. Eggman takes center stage in a story written by New York Times bestseller Gale Galligan (The Babysitters Club)! And how does the bad doctor celebrate the occasion? Only his Badniks know for sure... Finally, in "Sonic Learns to Drive," Sonic's up against a tough challenge: Driving! When the fastest thing alive can outrun any car, will Sonic have the patience to learn... or will he finally get left in the dust? Written by the hosts of My Brother, My Brother, and Me, The Adventure Zone, and New York Times bestsellers, the McElroy Brothers! Grab a slice of chili dog cake and don’t get left in the dust on the most way past cool book of the year!

For fans new and old, The Complete Sonic the Hedgehog Comic Encyclopedia takes readers through the entire 18+ year history of the Sonic comics! Featuring brand new, full-colour artwork from fan-favourite artists including SPAZ and Tracy Yardley!

"Unsung Heroes," Part Three. It's a race against time as Silver's squad must recover in time to rescue Elias and his squad! With Ixis Naugus's master plan nearing completion, will the Secret Freedom Fighters be able to stop him in time?

Together with other volumes in this series, Volume 53 presents thoughtful and forward-looking articles on developmental biology and developmental medicine. The exceptional reviews in this volume of Current Topics in Developmental Biology will be valuable to both clinical and fundamental researchers, as well as students and other professionals who want an introduction to current topics in cellular and molecular approaches to developmental biology and clinical problems of aberrant development. This volume in particular will be essential reading for anyone interested in stem cells, signaling, medical implications of developmental determinants, hematopoeisis, axis specification, and molecular genetics of development. - Includes a landmark review on Hedgehog genes and their gene products in invertebrate and vertebrate development - Presents major issues and astonishing discoveries at the forefront of modern developmental biology and developmental medicine - The longest-running forum for contemporary issues in developmental biology with over 30 years of coverage

Neuroblastoma is a medical enigma. As a childhood neoplasm arising from neural crest cells, it is characterized by diverse clinical behaviors ranging from spontaneous remission to rapid tumor progression and death. Although clinical outcome can be predicted to a large extent by the stage of disease and the age at diagnosis, an in-depth understanding of its clinico-pathological behavior, now greatly aided by sophisticated molecular genetic profiling, will improve diagnostic precision and refine risk-based therapies. Comprehensive international efforts have advanced our understanding of tumor biology and improved the clinical management of children with neuroblastoma. This book reviews our current understanding of the genes and biological pathways that contribute to neuroblastoma pathogenesis, modern risk-based treatment approaches for these patients, and recent advances in biologically based therapy. It provides a concise up-to-date reference for practitioners, students, and researchers.

In the rapidly-evolving landscape of neurosciences, it is no easy task to select a limited array of topics to present in a text such as this. The current volume takes as its purpose to provide a representative survey of the current science of brain repair for those seeking to establish a foundation in the field or to replenish a prior knowledge base that may have lapsed in its currency. It also hopes to offer insights into what remains elusive to our collective investigations, defining the “frontiers” of brain repair for those that are currently immersed in the exciting intersection of biological advances and neuroscientific discoveries. In Chapter 1 the fundamentals of imaging transplanted cells is discussed with emphasis on animal models as well as the horizon for clinical trials. Then, detailed methods on the culture of neural stem cells is reviewed as a foundation for approaching therapeutic goals. Chapter 3 presents the broad scope of animal models that serve as the foundation for developmental and pre-clinical investigation, with mention of recent genetically engineered mouse models that represent the best models for studying disease development and treatment. Chapter 4 provides background on the delivery techniques to animals and patients that are available, providing vital information on the subtleties of technique necessary for optimal cellular grafting. Chapters 5 and 6 discuss new and evolving information on the origins of brain tumors and the indelible role of stromal and microenvironmental influences on oncogenesis and tumor progression. Subsequently, the utility of neural stem cells as cellular vehicles to deliver chemotherapeutics to broad neuropathology is reviewed. In Chapter 8 the scope of treating brain tumors is expanded beyond stem cells, to present the best biological interventions to improve upon current treatment options for brain malignancy. The last two chapters present a comprehensive review on stem cell and gene therapy options for treating cerebrovascular and neurovascular pathology. In amassing this collection, my intention has been to provide the reader with a broad introduction into molecular imaging, stem cell biology, cell therapy, animal models, central nervous system malignancies, stroke, and neurodegeneration. My hope is that Frontiers of Brain Repair will be the intellectual soil from which a deeply rooted and well-nourished vintage of neuroscience will arise.