Solid Phase Synthesis of Combinatorial Peptide Libraries
Title | Solid Phase Synthesis of Combinatorial Peptide Libraries PDF eBook |
Author | Steven O. Mansoorabadi |
Publisher | |
Pages | 70 |
Release | 2000 |
Genre | Combinatorial chemistry |
ISBN |
Combinatorial Peptide and Nonpeptide Libraries
Title | Combinatorial Peptide and Nonpeptide Libraries PDF eBook |
Author | Günther Jung |
Publisher | John Wiley & Sons |
Pages | 571 |
Release | 2008-09-26 |
Genre | Science |
ISBN | 3527614907 |
With combinatorial chemistry millions of organic compounds can be produced simultaneously, quickly, and in most cases by automated procedures. These compound libraries are a cost-effective resource for the pharmaceutical industry in their search for biologically active lead structures. Furthermore simultaneous parallel synthesis of single peptides and peptide libraries solve the problem of the worldwide increasing demand for peptides. The synthetic methods described here in detail contribute to a forward-looking technology that has a high impact for industrial and academic research. Fast and efficient analytical techniques are essential for using the complicated product mixtures and detecting by-products. Various synthetic approaches and technologies, mass spectrometry, and screening assays are discussed extensively. This book is a must and an indispensible source of information for every researcher in this rapidly developing field, which spans organic synthesis, biochemistry, biotechnology, pharmaceutical, medicinal, and clinical chemistry.
Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries, 2002
Title | Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries, 2002 PDF eBook |
Author | |
Publisher | |
Pages | 330 |
Release | 2003 |
Genre | Nucleic acids |
ISBN |
Solid-Phase Synthesis and Combinatorial Technologies
Title | Solid-Phase Synthesis and Combinatorial Technologies PDF eBook |
Author | Pierfausto Seneci |
Publisher | John Wiley & Sons |
Pages | 653 |
Release | 2003-05-28 |
Genre | Science |
ISBN | 0471460737 |
A unique, integrated look at solid-phase synthesis and advances in combinatorial chemistry and technologies The last decade has seen a rapid expansion in combinatorial technologies, a field where chemistry disciplines intersect with automation, statistics, and information science, as well as certain biological disciplines. Reflecting these multidisciplinary trends, this new work provides a comprehensive overview of the most important aspects of solid-phase synthesis (SPS), combinatorial chemistry, and related combinatorial technologies. It clearly demonstrates how SPS and combinatorial chemistry have extended their application from the pharmaceutical arena to new areas, including biotechnology, material sciences, catalysis, and agrochemical industries, and explores in detail strategies for planning, designing, preparing, and testing of combinatorial libraries in various disciplines. Designed to meet the needs of both experienced combinatorial chemists and newcomers to the field, Solid-Phase Synthesis and Combinatorial Technologies: * Surveys the most recent developments in SPS and combinatorial chemistry * Explains the entire process, from determining the need for a library to the details necessary for synthesis of the library * Discusses choice of format, size, and the rationale behind the design of each synthetic step * Surveys the analytical techniques and the purification methods used to characterize and purify combinatorial libraries * Employs a large number of examples to illustrate important concepts * Includes problems geared toward applying acquired knowledge and designing the steps to SPS/library synthesis * Describes the quality control and activity screening of combinatorial libraries for various applications * Features a detailed bibliography of more than 1,700 relevant sources
Combinatorial Chemistry
Title | Combinatorial Chemistry PDF eBook |
Author | Stephen R. Wilson |
Publisher | John Wiley & Sons |
Pages | 288 |
Release | 1997-03-28 |
Genre | Medical |
ISBN | 9780471126874 |
The new time-saving revolution in drug discovery. Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working today. Using current advances in computer and laboratory techniques, combinatorial chemistry has freed professionals from the drudgery of piecemeal experimental work and opened new creative possibilities for experimentation. Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world's leading chemists, many of whom played a key role in its development. Including examples of both solution-phase and solid-phase approaches as well as the full complement of organic chemistry technologies currently available, the book describes: * Concepts and terms of combinatorial chemistry * Polymer-supported synthesis of organic compounds * Macro beads as microreactors * Solid-phase methods in combinatorial chemistry * Encoded combinatorial libraries, including Rf-encoding of synthesis beads * Strategies for combinatorial libraries of oligosaccharides * Combinatorial libraries of peptides, proteins, and antibodies using biological systems. While combinatorial chemistry originated in peptide chemistry, this volume has deliberately focused on nonpeptide organic applications, illustrating the technique's wide uses. Combinatorial Chemistry introduces organic, medicinal, and pharmaceutical chemists as well as biochemists to this exciting, cost-effective, and practical technique, which has unlocked creative potential for the next millennium.
Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries, 1998
Title | Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries, 1998 PDF eBook |
Author | Roger Epton |
Publisher | |
Pages | 472 |
Release | 1999 |
Genre | Nucleic acids |
ISBN |
Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries
Title | Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries PDF eBook |
Author | Roger Epton |
Publisher | |
Pages | 432 |
Release | 1999 |
Genre | |
ISBN |