This eighty-ninth volume of the IARC Monographs is the third and last of a series on tobacco-related agents. Volume 83 reported on the carcinogenicity of tobacco smoke and involuntary smoking (second-hand smoke or environmental tobacco smoke) (IARC 2004a). Volume 85 summarized the evidence on the carcinogenic risk of chewing betel quid with and without tobacco (IARC 2004b). That volume explored the variety of products chewed in South Asia and other parts of the word that contain areca nut in combination with other ingredients, often including tobacco. In this eighty-ninth volume, the carcinogenic risks associated with the use of smokeless tobacco, including chewing tobacco and snuff, are considered in a first monograph. The second monograph reviews some tobacco-specific nitrosamines. These agents were evaluated earlier in Volume 37 of the Monographs (IARC 1985) and information gathered since that time has been summarized and evaluated.

If you smoke and are unable or unwilling to quit, this approach can save your life. The book, For Smokers Only: How Smokeless Tobacco Can Save Your Life, provides concrete facts and valuable advice on a revolutionary quit-smoking strategy that is based on scientific research and common sense. Itis written by Dr. Brad Rodu, a leading authority on tobacco harm reduction, and a professor and senior scientist at the University of Alabama/Birmingham Comprehensive Cancer Center. Dr. Roduis stop-smoking strategy is based on three simple facts: 1. Smokers are addicted to nicotine, but nicotine does not cause cancer, heart attacks or emphysema. Those illnesses are caused by the other 3000 products of tobacco combustion. 2. Smokeless tobacco satisfies nicotine craving, but smokeless is 98% safer than smoking. 3. Todayis smokeless, spitless tobacco products can be used invisibly anytime, anywhere, much like a breath mint. "Please surf this site for lots of useful, factual information that can save your life, and the lives of your friends and loved ones." -- Dr. Brad Rodu"

Over 1,100 delegates from a hundred countries attended the 9th World Conference onTobaccoandHealth. Afterfivedaysofdebate, severalimportantresolutionswereadopted unanimously and will be landmarks in the fight against tobacco. This great success is due to three facts which emerged from the discussions: 1. Itappears clearlynowthattherisksassociated withtobaccoaremuchgreaterthan previously assumed. Out of two regular smokers, one will die from a tobacco­ related disease. 2. Reducing tobacco consumption can be achieved but the data collected in several countriesshowthatitrequiresaglobalstrategy.Thisstrategywasmuchdebatedduring theconference. Theresolutionsadoptedemphasizetheagreementofthedelegateson themainpoints. Actionto fight thegrowingepidemicoftobacco-attributabledisease and death involves convincing the general public, the medical community and decision-makers ofthe need to act for tobacco control. The most efficient tools for helping individuals never to start or successfully to stop using tobacco should be developed; effective tobacco control endeavors are required to counteractthe actions ofthe powerful and influential tobacco manufacturers. With the help and under the aegis ofWHO, DICC, IUATLD, ISFC, IOCD, and IUHPE, an international alliance for health and against tobacco shouldunite all those who are engaged in this fight.

The health and economic costs of tobacco use in military and veteran populations are high. In 2007, the Department of Veterans Affairs (VA) and the Department of Defense (DoD) requested that the Institute of Medicine (IOM) make recommendations on how to reduce tobacco initiation and encourage cessation in both military and veteran populations. In its 2009 report, Combating Tobacco in Military and Veteran Populations, the authoring committee concludes that to prevent tobacco initiation and encourage cessation, both DoD and VA should implement comprehensive tobacco-control programs.

Smokeless Tobacco Products: Characteristics, Usage, Health Effects, and Regulatory Implications, a title in the Emerging Issues in Analytical Chemistry series, presents an overview of research on the second most dangerous tobacco product. This book presents findings on public health risks emanating from the complex interaction between smokeless tobacco products and their users. It covers the key components of assessment and provides insight into scientific and public health considerations. The book does not take a simplistic condemnatory position, but rather conceptualizes tobacco use in terms of graduated public health danger and harm reduction. The book begins by introducing smokeless tobacco, its history of use, marketing, and implications for public health. It then continues with coverage of epidemiology, pathology and clinical implications, addiction, and treatment, and includes laboratory studies of human use. The following section explains the chemistry, biochemical mechanisms of carcinogenesis, and role of plant cultivation and manufacturing in toxicity. Finally, the book concludes by addressing regulatory considerations, the scientific basis of regulations, and the role of these products in harm reduction for smokers. This is the first resource of its kind to cover these topics together and in language appropriate to both specialists in the research community and informed persons responsible for legislative, funding, and public health matters in the community at large. - Brings attention to smokeless tobacco product use and its association with addiction and disease - Considers smokeless tobacco use historically and currently, as well as its place in a future harm-reduction conceptualization of tobacco - Written by a distinguished, internationally recognized group of tobacco researchers from academia, independent research organizations, and the federal government with expertise in the many and various disciplines covered

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.