Immunodermatology is a field covering the majority of skin diseases, including the most prevalent onesin the general population. The Second Edition of Skin Immune System (SIS) discusses immune-mediated skin diseases and disease groups in which the SIS plays a role. It covers major findings in immunophysiology and immunopathology that have occurred since the introduction of the First Edition in 1990. As the subtitle indicates, the Second Edition adds a new emphasis on cutaneous immunology, and also includes new information on immune-based therapeutic interventions and methods, such as phototherapy and the immunological therapy of skin cancer. The book contains Part I, with introductory chapters; Part II, with descriptions of the cellular elements; and Part III, which describes the humoral and molecular components of SIS. Part IV follows to integrate the facts described in Parts II and III into concepts of pathophysiology. It contains a number of concepts entitled "response patterns" that describe how the constitutional elements of SIS work together. New in this edition are the descriptions of immunodermatological diseases individually described in Part V. Part VI is also all new and summarizes principles of immunotherapy.

The aim of this comprehensive volume is to provide detailed and well-referenced information pertaining to the immunology of skin, particularly that of man. It includes a short description of comparative immunology plus an introduction into the skin immune system and skin associated lymphoid tissues. This section also describes adhesion molecules and their role in cell migration pathways. This interesting text provides up-to-date knowledge of keratinocytes, lymphocytes, Langerhans cells, monocytes, endothelial cells and mast cells. It describes the humoral constituents of the human integument's defense system, as well as the major response patterns of the skin immune system. This easy-to-read reference outlines future developments which are to be expected in the field of immunodermatology and the immunobiology of the integument. Those involved with immunology, biology, and dermatology will find this book interesting, informative, and indispensable.

Top scientific authors contribute their expertise and put a wealth of complex information into perspective in Skin Immune System: Cutaneous Immunology & Clinical Immunodermatology, Third Edition. This edition provides an overview of the skin immune system (SIS), a totally updated section on immunodermatological diseases, and six new chapters. Part I presents historical and comparative information on immunodermatology and includes a new chapter on the immunogenetics of inflammatory skin disease, while Part II covers the cellular elements of SIS and highlights newly defined functional subclasses of cells. Part III describes the humoral elements of SIS and provides two new chapters which focus on defensins and cathelicidins, and on the chemokines of human skin. Part IV discusses how the cellular and humoral elements of SIS interact under different circumstances and includes a new chapter on signal transduction pathways in cutaneous immunology. Part V focuses on dermatological diseases with a significant immunological background with a new chapter on the immunology of cutaneous drug eruptions, followed by Part VI on immunotherapy in dermatology, which features a new chapter reflecting the recent wave of products from biotechnology. Since the publication of the previous editions, a great deal of significant information has become available in almost all areas of cutaneous immunology and clinical immunodermatology. This progress has now been reflected in a completely updated and expanded resource.

Top scientific authors contribute their expertise and put a wealth of complex information into perspective in Skin Immune System: Cutaneous Immunology & Clinical Immunodermatology, Third Edition. This edition provides an overview of the skin immune system (SIS), a totally updated section on immunodermatological diseases, and six new chapters. Part I presents historical and comparative information on immunodermatology and includes a new chapter on the immunogenetics of inflammatory skin disease, while Part II covers the cellular elements of SIS and highlights newly defined functional subclasse.

Dermatologists are being asked to understand the pathophysiology of a number of immune-mediated skin diseases. In addition, a number of new products have appeared on the market during the past decade which requires an understanding of the mechanisms of action of these drugs. Dermatologists, however, have no easily understood book to which they can refer to regarding the disease or the drug.