The field of cochlear mechanics has received an increasing interest over the last few decades. In the majority of these studies the researchers use linear systems analysis or linear approximations of the nonlinear (NL) systems. Even though it has been clear that the intact cochlea operates nonlinearly, lack of tools for proper nonlinear analysis, and widely available tools for linear analysis still lead to inefficient and possibly incorrect interpretation of the biophysics of the cochlea. An example is the presumption that a change in cochlear stiffness at hair cell level must account for the observed change in tuning (or frequency mapping) due to prestin application. Hypotheses like this need to be addressed in a tutorial that is lucid enough to analyze and explain basic differences. Cochlear Mechanics presents a useful and mathematically justified/justifiable approach in the main part of the text, an approach that will be elucidated with clear examples. The book will be useful to scientists in auditory neuroscience, as well as graduate students in biophysics/biomedical engineering.

Although vital to our well-being and even to our success as a species, the physical sense of balance has never attained the same recognition as sight, hearing, touch, smell, or taste. Now, with an epidemic of debilitating falls sweeping America's aging population, the time is ripe for a lively and illuminating tour of the human body's most exquisitely intricate and least understood faculty. Balance is the first book written for a general audience that examines the mysteries of the human balance system -- the astonishingly complicated mechanisms that allow our bodies to counteract the force of gravity as we move through space. A scientific, historical, and practical exploration of how balance works, Balance also provides the keys to remaining upright for as long as humanly possible. From simple motion sickness to astronauts' "space stupids," and from fetal somersaults to the Flying Wallendas, McCredie guides readers on a delightful quest to elevate balance to its rightful place in the pantheon of the senses.

Neurotology is a branch of medicine that focuses on diagnosing and treating neurological conditions of the inner ear and related structures. There have been many recent advances in neurotology that have been published in general medicine, otolaryngology and neurology journals. This comprehensive book will aggregate this information to provide a more complete picture of the state of the field and will include the authors’ own clinical experience. There is a recent marked increase in interest in neurotology, manifested by the clinical experiences and research-publication work of otolaryngologists, neurologists, neuro-ophtalmologists, audiologists and physiotherapists. As a result, this will be a completely state-of-the-art work that includes all up-to-date neurophysiological data related to the vestibular system. It has been estimated that 10% of patients that present at an emergency clinic have vestibular disorders, including vertigo, and these disorders are frequently a cause of falls in elderly patients. On the other hand, many physicians treat their patients with vertigo with vestibular blockers, which treat the symptoms but do not cure the disorders. We feel that it is important to supply a source of information on the vestibular system and balance disorders, and this title will do that in a comprehensive manner. This title will be an ideal reference for the diagnosis and treatment of vestibular disorders for otolaryngologists, neurologists, neuro-ophtalmologists, audiologists and physical therapists.

Attention, Balance and Coordination is the most up-to-date handbook for professionals involved in education and child development, providing a new understanding of the source of specific behavioural problems. Written by a respected author of acclaimed titles in this field Explains why early reflexes are important, their functions in development and their effects on learning, behaviour and beyond - also covers adult neurological dysfunctions anxiety and agoraphobia Builds on an ABC of Attention, Balance and Coordination to create a unique look across specific learning difficulties, linked by common motor skills challenges resulting from neuro-developmental deficiencies Includes the INPP Developmental Screening Questionnaire together with guidance on how to use and interpret it

Following the success of the first edition, this book is designed to provide practical and timely information for toxicologic pathologists working in pharmaceutical drug discovery and development. The majority of the book (Organ Systems) will provide detailed descriptions of histopathological lesions observed in drug development. In addition, it will provide information to assist the pathologist in making determinations of the origin of lesions as well as its relevance to human risk. Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition includes 2 new concept chapters. The first of the new chapters address approaches for the evaluation of unique therapeutic modalities such as cell therapies, gene therapies, and gene expression knockdown therapies. While these still represent new developing therapeutic approaches, there has been significant experience with the therapeutic modalities in the last 5 years. The second new chapter addresses the nonclinical safety assessment of medical devices, a topic of increasing importance that was not addressed in a unique chapter in the first edition. The other concept chapters have been updated and cover important topics including the overview of drug development; principles of nonclinical safety assessment; an introduction to toxicologic pathology; techniques used in toxicologic pathology, clinical pathology, toxicokinetics, and drug development toxicogenomics; and spontaneous lesions. The 13 organ system chapters provide the specifics related to pathologic characteristics, differential diagnosis, and interpretation of toxic responses in each organ system. These chapters are specifically important for the bench pathologist but also for the toxicologist who interacts with pathologists and function as study toxicologists and project team representatives in the drug development arena.

"John Hughlings Jackson (1835-1911) was a preeminent British neurologist in the nineteenth and early twentieth centuries. He began to establish that standing in the 1860s, when he incorporated the evolutionary association psychology of Herbert Spencer into his early analyses of 'loss of speech' (aphasia). Jackson also benefitted from his early connection with the National Hospital, Queen Square, London, becoming its leading theorist. His nuanced theory of cerebral localization was derived from (1) his clinical observations of (what Charcot later called) Jacksonian epilepsy, in combination with (2) his innovation to think about neurophysiological events at the cellular level, as well as from (3) David Ferrier's primate localization data. The result was our modern conception of the seizure focus. The latter was crucial to the beginnings of modern 'brain surgery,' especially at the hands of Victor Horsley. Jackson's influence on the neurophysiology of Charles Sherrington is widely acknowledged but not well defined. In the larger Victorian culture, Jackson was a friend of George Henry Lewes, who was George Eliot's companion. Lewes attributed 'sensibility' to everything in the nervous system, thus maintaining a monist position on the mind-body relation, whereas Jackson maintained a form of psycho-physical parallelism that was actually dualist ('Concomitance'). Throughout his life Jackson had an interest in insanity, which he viewed from the point of view of Spencerian evolution and dissolution. The latter was an important component of Freud's psychoanalysis, which Freud took from Jackson. Late in his life Jackson defined the 'uncinate group of fits,' which was his definition of temporal lobe epilepsy"--