Cell-Penetrating Peptides The definitive reference on the rational design of cell-penetrating peptides enables readers to develop tailor-made peptides for their specific needs. In recent years, cell-penetrating peptides (CPPs) have become valuable tools for the cellular delivery of proteins, nucleic acids, and drugs. These small peptide sequences can be artificially designed and synthesized with custom-made characteristics to mediate the efficient and non-toxic transport of biomolecules, drugs, or nanoparticles into the cell. Cell-Penetrating Peptides: Design, Development, and Applications provides an up-to-date account of the development and use of CPPs for delivering membrane-impermeable bioactive molecules into cells. Bringing together contributions from leading researchers from around the world, this comprehensive volume describes the characteristics and mechanisms of CPPs as well as their application in both medicine, biotechnology and agriculture. Covers rational design and development of cell-penetrating peptides for use in cellular delivery of small molecule drugs, proteins, nucleic acids, and nanoparticles Presents the chemical and biological characteristics of CPP action in vitro and in vivo Describes the structure and design principles of both synthetic and naturally occurring CPPs Discusses key medical applications of CPPs such as oral delivery, intranasal delivery, and clinical trials Cell-Penetrating Peptides: Design, Development, and Applications is an essential resource for biochemists, medicinal chemists, molecular biologists, biotechnologists, and researchers studying CPPs in both academia and industry.

Accompanying CD-ROM contains ... "folders (in Gis format and in Graphics format).--CD-ROM label.

This sweeping history reorients our understanding of the Middle East, placing the Gulf at the heart of globalized trade and cross-cultural encounters. World history began in the Persian Gulf. The ancient port cities that dotted its coastlines created the first global seaboard, a place from where faiths and cultures from around the world set sail and made contact. More than a history, The Center of the World shows us that contradictions that define our modern age have always been present. For over four thousand years, the Gulf—sometimes called the Persian Gulf, sometimes the Arabian Gulf—has been a global crossroads while managing to avoid control by the world’s greatest empires. In its history, we see a world of rapid change, fluctuating centers of trade, a dependency on uncertain global markets, and intense cross-cultural encounters that hold a mirror to the contemporary world. Focusing each chapter on a different port around the Gulf, The Center of the World shows how the people of the Gulf adapted to larger changes in world history, creating a system of free trade, merchant rule, and commerce that continues to define the region today.

Sir Arnold Talbot Wilson (1884-1940) was a British colonial administrator, soldier, and politician. He graduated from the Royal Military Academy Sandhurst in 1903 and served as an officer in the British Army in India. He was transferred to the Indian Political Department and subsequently sent to the Persian Gulf. Wilson was the British civil commissioner in Baghdad in 1918-20. Although he was credited with improving the country's administration, he was criticized for his violent repression of the 1920 Iraqi revolt against the British. At the 1919 Paris Peace Conference that followed World War I, he successfully recommended changing the Greek name "Mesopotamia" to the Arabic "Iraq." However, the British government ultimately rejected his view that Iraq should not be granted independence, and he was removed from his position. Wilson later became a member of Parliament. With the outbreak of World War II, he joined the Royal Air Force Volunteer Reserve. He served as a pilot officer and was killed in action in northern France. The Persian Gulf. An Historical Sketch from the Earliest Times to the Beginning of the Twentieth Century is a concise history of the region. Wilson begins with the writings of Greek, Roman, and Muslim geographers, followed by chapters on the arrival of European powers, beginning with the Portuguese, the British, and the Dutch. A later chapter discusses the growth of the British influence, starting in the 18th century. Other topics covered in the book are piracy, the slave trade, and the growth of Arab principalities.

This is the definitive survey of Islamic architecture. Working from a social, rather than a technical perspective, Hillenbrand shows how the buildings fulfilled their intended functions within the community. Lavishly illustrated.

For the last century and a half, the name of Padang Lawas, in the present province of North Sumatra, Indonesia, has been associated with a number of isolated Hindu- Buddhist remains located in the middle of the island. These remains are all the more remarkable because they form the largest Indianized archaeological complex yet to be seen in the northern half of Sumatra. This book is the latest contribution to the accumulation of knowledge on the ancient history of Padang Lawas. The ?fteen studies brought together here present the main results of the archaeological research programme conducted from 2006 until 2010 by the Ecole francaise d’Extréme-Orient in cooperation with the Indonesian National Centre for Archaeological Research. This programme was focused on one of the sites known in this region, namely Si Pamutung, presently located near the con?uence of the Bammun and Batang Pane Rivers. These contributions are devoted ?rstly to the directly visible features of Si Pamutung, namely its environmental setting and its Hindu-Buddhist remains made of brick and stone.

Exploring the history of the Persian Gulf from ancient times until the present day, leading authorities treat the internal history of the region and describe the role outsiders have played there. The book focuses on the unity and identity of Gulf society and how the Gulf historically has been part of a cosmopolitan Indian Ocean world.